Karnataka | Night curfew to begin from 8 pm; Sunday lockdown from July 5

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Newsroom, Feb 2: American business magnate Bill Gates has congratulated her daughter Jennifer Gates after she announced her engagement to her Muslim boyfriend Nayel Nassar.

“I am completely thrilled! Congratulations, @jenniferkgates and @nayelnassar”, commented the Microsoft boss to her daughter’s surprise Instagram story.

The proposal took place on a ski getaway. "Nayel Nassar, you are one of a kind. Absolutely swept me off my feet this past weekend, surprising me in the most meaningful location over one of our many shared passions," she wrote on Instagram. The pair does have one very significant shared passion - horses.

Nassar, 29, is a showjumper. Gates, 23, has famously grown up an equestrian, and has even competed against Steve Jobs' daughter.

In October, Nassar helped Egypt qualify for Tokyo 2020 - Egypt's first Olympic equestrian qualification in 60 years. He has been jumping since he was 10 years old and has the accolades to show for it - he has taken first place in a number of notable competitions, including the Longines FEI Jumping World Cup.

Nassar was born in Chicago to Egyptian parents and spent many of his formative years in Kuwait, where his well-to-do parents run an architecture and design firm, according to People. He is fluent in English, Arabic, and French.

He moved back to the US in 2009 and graduated from Stanford with an economics degree in 2013 - later, he supported Gates at her own Stanford graduation in 2018.

The couple received well wishes from many notable personalities on each of their Instagram posts, including comments from Bill and Melinda Gates, Georgina Bloomberg, and Eve Jobs.

 

 

 

 

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Happy birthday @nayelnassar, can’t begin to put into words how extraordinary you are. The most compassionate, intelligent, hilarious, supportive, warm, humble human being. Wishing you all the joy in the world today and all the years to come

A post shared by Jennifer Gates (@jenniferkgates) on Jan 21, 2020 at 8:44am PST

The Centre’s step-motherly attitude towards Kannadigas stranded in the Gulf countries in general and Saudi Arabia in particular has prompted the Kannadigas to resort social media campaign once again.

A couple of weeks ago, Twitterati had launched a campaigned to bring back Kannadidags stranded in Saudi Arabia. A variation of the hashtag #SaudiKannadigasNeedFlights trended today. 

Trend Setters India, which has taken the twitter campaign initiative, had urged the Kannadigas around the world to join the twitter storm at 4 p.m. IST on June 15, to exert pressure on the authorities concerned. Around 7 p.m. the hashtag began trending with thousands of tweets.

Millions of Kannadigas are working in Middle Eastern countries like Saudi Arabia and United Arab Emirates. They contribute greatly to the Indian economy.

Even though government of India has launched Vande Bharat Mission for the repatriation of Indians stranded across the world, it has operated only a few flights from Saudi Arabia to Karnataka so far. Thousands of Kannadigas including pregnant women, elderly people, those who have lost jobs and those who need emergency medical care are still waiting for repatriation flights from Saudi Arabia to Mangaluru and Bengaluru.