Local residents bring Suratkal-Kana-MRPL road to a standstill

Bengaluru, Mar 28: Karnataka Pradesh Congress Committee (KPCC) chief DK Shivakumar on Saturday appealed to the authorities to arrange transport for migrant workers, stating that it is appalling to see their plight as they are walking hundreds of kilometres to their villages amid COVID-19 lockdown.
"Appalling to see the plight of poor migrant workers who are walking hundreds of kms to their villages. We cannot abandon our citizens, especially children, and put them at risk. Appealing to the authorities to arrange transport. Please take sufficient safety precautions as well," Shivakumar tweeted.
Hundreds of people, comprising mostly of migrant workers and their families, gathered at the Lal Kua in Uttar Pradesh from Delhi, Gurugram and other places, to take buses to their respective destinations amid the lockdown.
While the Prime Minister Narendra Modi had imposed a nationwide lockdown to prevent the spread of coronavirus, the Uttar Pradesh administration had decided to ply these buses to help thousands of migrant workers who were stuck in the national capital and had started returning on foot to their native places in Bihar, Uttar Pradesh, among others.

Bengaluru, Apr 28: Ayurveda company, TotalAyurvedaCare.com recently launched a novel telemedicine platform that blends traditional Ayurvedic practices with modern technology, giving patients face-to-face interactions with Ayurvedic doctors.

Through the website, patients can book an appointment with a doctor and receive a consultation. Following this consultation, the doctor will prescribe Ayurvedic medicines and provide nutritional advice.

"COVID-19 has brought many unexpected changes to our lives, especially in the healthcare sectors where patients are now asked not to visit hospitals or doctors clinics unless it is a dire emergency. While social distancing and hand washing are some of the keys to containing the spread of the virus, we realized that boosting one's immunity plays a very vital role in keeping healthy. Our Telemedicine portal is ideal as patients can have access to Ayurvedic doctors at the comfort of their homes while minimizing risk to both patient and doctor", said Ed Lateef, Founder and CEO of TotalAyurvedaCare.com.

"The holistic care and treatment is completely personalized for every individual. With highly qualified and experienced doctors, we are on a mission to make the global community a healthy and happy place with Ayurveda. The online platform of TotalAyurvedaCare.com is for everyone to transform their lives. Ayurveda is the science of life and longevity and teaches us about the power of nature, its cycles, and its elements. We understand that Ayurveda is aimed at not only treating the condition but also helps to maintain the balance of soul and mind", he added.

TotalAyurvedaCare's objective is to increase accessibility of Ayurvedic treatments, with the streamlined website allowing patients to register for online consultation easily.

During the registration process, the patient will have to select their condition, doctor of choice and schedule the appointment. Payments occur online through a secured payment gateway.

Currently, the platform supports payment methods including netbanking, debit card, credit card, and PayTM. The platform also allows patients to review their doctors.

TotalAyurvedaCare.com is a division of Total Herbal Care, a company with strategic interests in herbal brands. Founded by Ed Lateef in 2001, for the retail and distribution of Ayurvedic products in the US, it also began operations in Europe in 2003 and then was merged with The Himalaya Drug Company LTD Europe (SIA The Himalaya Drug Company), which was co-founded by Ed Lateef.

As a part of their launch, TotalAyurvedaCare.com is offering free appointments of 30 minutes each for the first 200 participants. The online Ayurvedic Doctor consultation from Total Ayurveda Care is suitable for all the age groups including children.

The highly qualified and experienced Ayurvedic physicians offer personalized consultation for multiple health issues like diabetes, obesity, skin conditions, hair issues, hypertension, stress, anxiety, gastrointestinal problems, etc.

Total Ayurveda Care also offers specialized nutritional consulting, which is based on your current state of health, dietary habits and health issues.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.