Mangalureans urged to help catch this Gujarati woman who abducted an activist’s daughter

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Feb 26: Karnataka Minister CT Ravi on Wednesday said that time is ripe to bring in Uniform Civil Code in the country as there was a demand for "equality".

"Everyone talks about equality. Those who desired inequality in the past are now seeking equality. The time is ripe to bring Uniform Civil Code," he said.

The Minister said that the Uniform Civil Code (UCC) has been a part of the party's agenda since the time when BJP was formed in 1980.

"We spoke about article 370, we have done it, on Ayodhya issue, the Supreme Court has given its verdict. As the time comes we will do it," he said.

Mangaluru, May 29: The southwest monsoon is expected to reach the Karnataka coast on June 1 or 2, earlier than forecast by the India Meteorological Department (IMD).

Normally, Karnataka witnesses the onset of monsoon either five or six days after it had entered Kerala. However, this time, Karnataka will also witness the arrival of monsoon either on June 1 or June 2, according to meteorologists at the Karnataka State Natural Disaster Monitoring Cell (KSNDMC).

The gradual formation of two low-pressure areas over the Arabian Sea located close to the western peninsular coast and gaining momentum has helped Karnataka mark the start of the four-month-long rainy season expected to revive the back-to-back drought-stricken state.

Confirming the changes in the atmospheric pattern, Dr GS Srinivasa Reddy, Director KSNDMC said, “Karnataka will also witness the onset of monsoon on the same time that of Kerala.”

The early onset of monsoon over Karnataka coast is attributed to prevailing to weather pattern over the Arabian Sea. 

“The two low-pressure areas over the Arabian Sea are steadily gaining momentum. They may reach the peak by the weekend and may concentrate further into depression causing widespread rainfall in the peninsular region and thereby advancing the onset of monsoon over the region,” Dr Reddy explained.

The KSNDMC, based on the Indian Meteorological Department (IMD) forecast, stated that due to 'prevailing favourable conditions over the Indian Ocean and Pacific Ocean regions', the monsoon will be normal and above normal over coastal and south-interior Karnataka according to the present scenario.

The IMD, which had initially issued a forecast of five-day delay in the onset, had issued a fresh forecast on Wednesday cautioning the states along the West coast about the formation of two intense low-pressure areas in South-East and East-Central Arabian Sea region.

Following the forecast, a yellow alert has also been issued in Kerala and coastal areas suggesting significant rainfall starting from this weekend. “Fishermen have also been advised not to venture into deep-sea due to high turbulent conditions,” an IMD official revealed.