Mangaluru: 5th Beary literary convention in December

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Apr 11: The coronavirus-driven lockdown will continue for another 15 days, but relaxations will be allowed in a graded manner, Karnataka Chief Minister B S Yediyurappa said after a four-hour-long video conference with Prime Minister Narendra Modi on Saturday.

“Agriculture and industrial sectors will be given relaxation. Government offices will be allowed to work with partial strength. But the PM said detailed guidelines will be issued in two days,” Yediyurappa said, briefing reporters. 

“Importantly, the lockdown for the next two weeks will be different than how it was in the past three weeks. The Centre, keeping in mind economic activities, especially agriculture, industry and employment of labourers, the Centre will tell us what needs to be done,” the CM said.
 
According to Yediyurappa, PM Modi told all chief ministers that the next 2-3 weeks will be critical. “The next few weeks will decide whether or not we have succeeded. If the situation worsens, we have to face the crisis,” Yediyurappa said, quoting Modi. 

Apparently, Modi sought details on the COVID-19 situation from 12-13 states where the situation is grave. “He did not take a report from Karnataka,” Yediyurappa said. “This morning, seven new cases were reported in the state, taking our tally to 214. Nationally, we were in the third place; we’re now 11th,” he said, hailing the efforts of officials involved in fighting the pandemic. 

The CM said it was “inevitable” to continue the lockdown for another 15 days. “But for citizens to get essential supplies, there’s no bar on them going by walk alone. Also, we will see to it that agricultural activities are not affected anywhere,” Yediyurappa said.

Bengaluru, Jun 19: Congress leaders BK Hariprasad and Naseer Ahmed filed their nominations as party candidates for Legislative Council elections in Bengaluru and KPCC chief DK Shivakumar said that the two leaders have been given ticket to strengthen the party with their guidance.

"The Legislative Council means the Upper House and the Elders House. We have unanimously agreed to select and send these two senior leaders to discuss the party organization and various issues of the state in Legislative Council. There were plenty of aspirants to enter the Upper House. But it is decided to elect these two leaders and they will contest the election," Shivakumar said.

"We need seniority to guide us... That's the reason we are selecting these leaders... The high command has given these senior leaders the opportunity to discuss with all our leaders about strengthening the party," he added.

The elections are scheduled to be held on June 29.