May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.
According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.
"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.
They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.
Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.
"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.
"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.
In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.
"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.
The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.
These children were then confirmed to have COVID-19.
While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.
Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.
According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.
"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.
Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.
While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.
However, he cautioned that more research is needed to confirm their findings.
"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.
Comments
Hats off to the above teamwork
A wonderful selfless act. He must have been a compassionate person.
Oh, my heart breaks for the family. My family also had to make the decision to donate my niece's organs. For me personally it was one of the most healing things knowing she had saved so many lives but I do often wonder how/where these people are.
Selflessness - the stuff of real heroes.
As a recipient of a heart just over two years ago I am eternally grateful for those who make this decision. I can continue to be a son, a husband, and a father to two small children.
My brother passed unexpectedly on 24th February 2015, he too donated his organs. His selfless act has helped us, as a family to know he breaths through another & has assisted at least four other recipients & their families last year. We would love to reach out to the recipients on his 1yr memorial but understand the sensitivity for some and respect their privacy but it's hard.... I know it would mean the world to mum & dad to meet them & would greatly assist in their healing. I wish there was a 'tick box' option to opt in for communication between families.
My deepest condolences to his family and friends on his passing. Organ donation is a befitting gesture to honour this young man. With much love to you all at his difficult time.
Feel sorry for the man and his family...life is unpredictable.
RIP!!! You r a real hero buddy...
these idiots will construct green corridors with lot of potholes. do practical and proper work rather than bs talk
Why drones flying at low heights in some Specific colour can not be used for Organ Transportation?
At times the Mangalore Police makes us proud and kudos to the team that coordinated with the transplant team of one and all.
Very good. Appreciated the good work Police department
he has shown that humanity does still exist in India. well done,. May Almighty Bless him , this deceased Son as well as the patients who received the organs. Kudos ot medical fraternity along with police who made this happen
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