Mangaluru welcomes 2016 with gusto

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, May 28: As many as 115 new coronavirus cases were reported in Karnataka on Thursday taking the infection count to 2,533, Karnataka Minister S Suresh said.

The total coronavirus cases include 834 discharges, 1,650 active cases, 47 deaths so far due to the disease and two deaths due non-COVID causes, Suresh Kumar, who is minister for primary and secondary education, said during the daily COVID-19 briefing.

According to him, 29 cases were reported in Udupi on Thursday, followed by 24 in Dakshina Kannada district, 13 in Hassan, 12 in Bidar, nine in Bengaluru Urban, seven in Yadagiri, six in Chitradurga, five in Kalaburagi, four in Haveri, three in Chikkamagaluru, two in Vijayapura and one in Raichur.

The minister said among the new cases, 95 are inter-state passengers and two international passengers.

According to the health department, 84 infected people have returned from Maharashtra and eight from Tamil Nadu.

Among those discharged today, 13 are in Davangere, 12 in Dakshina Kannada, nine each in Yadagiri and Vijayapura, five in Gadag, three in Belagavi, one each in Mysuru and Bagalkote.

Two are severe acute respiratory infection cases.

There were, however, no coronavirus related deaths in the state today, the minister said.

Kumar said the government has issued another circular making changes in the quarantine rules.

"A person who has completed seven days of institutional quarantine and is asymptomatic can be permitted for home quarantine without a COVID test, subject to undergoing medical check-up," the minister said.

According to the circular, all elderly people of above 60 years of age and those with comorbidities such as diabetes, hypertension, asthma, heart ailment and renal diseases, are required to be clinically evaluated diligently prior to shifting them to home quarantine.

Such people will be under mandatory home quarantine for seven days, the circular read.

Thiruvananthapuram, Mar 29: Twenty more people were

detected with coronavirus in Kerala on Saturday, taking the total number of those undergoing treatment for the deadly infection to 181, Health Minister K K Shailaja said.

While Kannur reported eight cases, Kasaragod 7, Thiruvananthapuram, Ernkulam, Thrissur, Palakad and Malappuram reported one case each, Shailaja said in a statement here.

Of the 20 people, 18 had come from abroad and two others had been infected through contact.

The man found positive here was in the isolation ICU of the Thiruvananthapuram Medical College hospital, while one positive case from Ernakulam was a health worker.

The samples of four persons who were under treatment at Pathnamthitta were found negative.

At least, 1,41,211 people are under observation across the state, the Minister addd.