Mangaluru woman returns home after Saudi ordeal; thanks ISF for timely help

Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

Bengaluru, Feb 4: Karnataka High Court on Monday reserved order on plea, seeking cancellation of bail granted to Nithyananda for skipping the trial and fleeing the country.

After hearing the arguments, the court has reserved the matter for further orders which will be pronounced on February 5.

The plea, which was filed in the high court on January 23, was heard by Justice John Michael Cunha.

The counsel for the complainant Lenin put forth arguments that the self-styled godman Swami Nithyananda had fled the country to escape the trial. "Nityananda has been claiming to be in India in his exemption petitions filed before the trial court but during that time he sought asylum in Ecuador and is having a second passport," said Lenin.

The prosecutor informed the court that they do not need his presence for the trial at this time.

Nithyananda, accused of rape and child abuse, has been absconding since November 2018.

In December 2019, the Ministry of External Affairs said that the passport of Nithyananda was cancelled and a fresh application of the same was denied as he did not get the requisite clearance from police and several criminal cases have been lodged against him.

Police in Ahmedabad had arrested two woman administrators of the ashram, allegedly owned by Nithyananda, and freed two boys who were held captive there.

Two of his disciples, Pranpriya and Priyatattva, were arrested on the basis of a complaint filed by one Janardhan Sharma who alleged that his daughter was held captive in Nithyananda's ashram.

The police took the two women to Nithyananda's ashram in Hathiajan for an investigation and seized laptops, mobile phones among other things.

Belgaum, Mar 26: The police on Thursday thrashed people who had gone to offer prayers at a mosque despite the nationwide lockdown in force.
In a video, the police personnel can be seen thrashing the people with batons while they were leaving after offering prayers at a local mosque here.
In another incident in Rajasthan's Pratapgarh, the police made few youngsters hop along a road and even gave the 'murga,' punishment to a few of them for violating the restrictions.
Similarly in Uttar Pradesh's Budaun, the police made people hop along a road with their bags strapped on their backs as a punishment. The people were possibly going to their native places.
In the video of the Budaun incident, a few men can be seen being made to hop along the road with a stick-wielding policeman keeping a watch.
SSP Budaun told ANI that an investigation is being conducted into the incident and expressed an apology for the police's behaviour.
Prime Minister Narendra Modi had announced a 21-day countrywide lockdown to check the spread of coronavirus, saying that "social distancing" is the only option to deal with the highly contagious disease.