Manglauru: Doctors at Unity hospital save arm of 10-yr-old cancer patient through rare surgery

Bengaluru, Apr 27: Former Prime Minister H D Deve Gowda on Monday demanded that the Karnataka government announce a special package for farmers who are on the verge of quitting agriculture as their profession following losses due to the COVID-19 pandemic.

"Please announce special package for the farmers to bail them out of the loss due to the lockdown.

Drop many of the schemes in the budget but don't leave the farmers in distress," Gowda said in his letter to Chief Minister B S Yediyurappa.

The JD(S) supremo said the way relief has been announced for the milk producers by procuring the unsold milk and distributing it to the slum dwellers, the same assistance should be provided to the farmers of the state.

"If you don't come forward to assist the farmers, then they will be forced to sell their land," Gowda cautioned the Chief Minister.

The former prime minister said the farmers are on the verge of falling in the debt trap and may be compelled to take the extreme step of suicide due to the losses.

Gowda said the farmers are unable to sell their crop because they are not getting proper price for their produce and are selling their crop at a throwaway price to minimise their losses.

"In just one month farmers reached the brink of bankruptcy as they are unable to sell the standing crops in lakhs of acres of land," Gowda said.

The JD(S) supremo has been championing the cause of farmers in the state and highlighting their sufferings.

On April 3 Gowda has appealed to Prime Minister Narendra Modi to look into the plight of farmers, labourers and the middle class people due to the lockdown.

"In such times of crisis, we should see to it that there is no disruption in farming activities by ensuring proper marketing channels to agricultural produce, especially perishables.

Only then we can sustain our long battle against this pandemic," Gowda said in a tweet.

Dubai, Feb 11: An Indian national has been diagnosed with the novel coronavirus in the UAE, bringing the total number of confirmed infection cases to eight, the country's health ministry has said.

The death toll in China's coronavirus outbreak has gone up to 1,016 while the confirmed cases of infection have soared to 42,638, Chinese health officials said on Tuesday.

The UAE Ministry of Health and Prevention (MoHAP) said on Monday that the Indian national was infected after he interacted with a recently diagnosed person.

"The Ministry of Health and Prevention announced today the eighth confirmed case of new coronavirus in the UAE, which is an Indian national who had interacted with a recently diagnosed person," it said in a tweet.

On Sunday, the ministry said that the two new patients, a Chinese national and a Filipino, had been diagnosed with the disease and were receiving medical care as per the highest health standards available in the country.

It said that all health facilities will continue to report any new cases suspected to have coronavirus.

Last week, a family of four who arrived from Wuhan for a holiday in Dubai were diagnosed with coronavirus. A fifth patient, who also arrived from the Chinese city, was confirmed to have been infected with 
the virus, but is reportedly in a stable condition.

China and countries around the world are scrambling to contain the spread of coronavirus which fiirst surfaced in Wuhan city in the Central Hubei province of China. Apart from China, two deaths have occurred in Hong Kong and the Philippines.

Besides Germany, Britain and Italy, other European nations with cases of the virus include France, Russia, Belgium, Sweden, Finland and Spain.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.