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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Thiruvananthapuram, Jan 3: Kerala Chief Minister Pinarayi Vijayan on Friday wrote letters to 11 Chief Ministers including Arvind Kejriwal--Delhi and Mamata Banerjee, West Bengal-- pointing out apprehensions that had arisen among large sections of society consequent to the Citizenship Amendment Act (CAA) - 2019.

In his letter, the Chief Minister said "the need of the hour is unity among all Indians who wish to protect and preserve our cherished values of democracy and secularism."

People from various cross-sections of the society irrespective of any difference they might have, need to stand united in preserving the basic tenets of our polity which form the cornerstone of Indian democracy, he added.

"We are sure that our unity in diversity, which has stood the test of times will ultimately emerge stronger. Kerala has decided to address the apprehensions about NRC and that preparation of NPR will lead to NRC by staying all activities relating to NPR in the State," Mr Vijayan said.

In this regard, the Kerala Legislative Assembly had passed the resolution on December 31, 2019, expressing its concern regarding the impact the CAA will have on the nation's secular credentials, he said.

"The resolution requested the Central Government to repeal the CAA, 2019. States, which have the opinion that CAA should be repealed can also consider similar steps so that it will be an eye-opener to the proponents of the CAA and the NRC," the Chief Minister pointed out.

Mangaluru, Jul 2: As many as 90 persons have tested positive for covid-19 in last 24 hours in Dakshina Kannada district. 

With this, the total number of coronavirus positive cases in the district mounted to 915. 

Out of the 90 positive cases, fifteen persons had returned from Kuwait, Saudi Arabia and Dubai. A BJP MLA, DHO and a pathologist are also among those who infected.