Muhammad' Ali, the only STAR mounted on Walk of Fame wall, not on floor

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, June 1: Prime Minister Narendra Modi today praised the Karnataka government for its handling of the COVID-19 pandemic.

Addressing the silver jubilee celebrations of the Rajiv Gandhi University of Health Sciences (RGUHS) via a digital platform, he spoke about the Karnataka government's efforts.

He appreciated the work of front-line warriors who are fighting every day in the war against COVID-19 and stressed the need to respect them.

"Doctors and other medical workers are soldiers without wearing the uniform of soldiers. Any kind of attack or violence against them is not acceptable," said Modi.

"There are incidents of violence against the front-line warriors. Any kind of abuse, violence or rude behaviour is not acceptable. The world is looking at doctors and medical staff with gratitude," he said.

"This is the biggest crisis since the two World Wars," the prime minister said. "Pre- and post-COVID-19, the world will be different. The discussions now at a global level are humanity-centric."

Stressing the importance of medical infrastructure, the prime minister spoke about the decision taken by the Union Government to set up a medical college in every district.

"A nation like ours has to have the medical infrastructure and medical education. Now, every district is going to have a medical college," he said.

However, the PM remained silent on salaries of front-line warriors. The Karnataka government has so far not released the salaries of doctors, nurses and lab technicians hired under National Health Mission.

Bengaluru, Mar 19: As a precautionary measure to prevent the spread of coronavirus, the Karnataka State Board of Auqaf has issued an advisory to mosques, dargahs and other religious institutions, requesting them to conclude the Friday congregation in 15 minutes for the next three weeks.

"Respected head of masjids and imams (prayer leader) are requested to conclude the entire Juma congregation (including Juma khutbah, salah and dua) in 15 minutes for the next three weeks and avoid using the public mic for the khutbah and salah," read a statement from the Karnataka State Board of Auqaf.

It has advised to ensure cleanliness and good hygiene inside mosques and keep the carpets, prayer mats, floor mats etc clean.

Further, it stated that those coming for daily prayers should be instructed to perform wudhu (ablution) at their homes and avoid using prayer caps placed in masjids.

"Please remove the public towels and prayer caps from the masjids. Sunnah and nafil prayers should observed at home," the advisory read.

The advisory came as the number of coronavirus patients spiralled across the country. The governments are taking all precautionary measures to contain the spread of the virus that has claimed more than 7,500 lives across the globe since its outbreak in China in December last year.