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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Apr 9: 10 new positive cases have been confirmed in Karnataka, apart from the recent fatality of an 80-year-old woman from Gadag district, the health department said on Thursday.

The fresh cases have been reported in the state from last evening to Thursday noon.

Till date, 191 COVID-19 positive cases have been confirmed, which includes 6 deaths and 28 discharges, the update said.

Among the 10 positive cases, eight are contacts of patients who have already tested positive- one each from Belagavi, Mandya and Chikkaballapura, two from Mysuru, and three from Bagalkote; while two from Bengaluru city are with a travel history to Delhi.

Three cases from Bagalkote are children- two boys of 4 and 13 years of age, and one girl of 9 years old.

The elderly woman died on April 8 in Gadag, the department said in its mid-day situation update.

Confirming that her reports tested positive on April 7, officials had said, she had a history of Severe Acute Respiratory Infection (SARI).

Bengaluru, Jan 3: Prime Minister Narendra Modi on Friday called on young scientists of India to "Innovate, Patent, Produce and Prosper," and said these four steps would lead our country towards faster development. The Prime Minister also stressed on the need to transform the landscape of Indian science, technology and innovation.

"The growth story of India depends on its success in the science and technology sector. There is a need to transform the landscape of Indian science, technology and innovation," Modi said.

Speaking after inaugurating the 107th Session of Indian Science Congress, he said, "My motto for the young scientists in this country is -Innovate, Patent, Produce and Prosper. These four steps will lead our country towards faster development."

"If we innovate we will patent and that in turn will make our production smoother and when we take these products to the people of our country, I'm sure they will prosper," he said, adding that innovation for the people and by the people is the direction of our new India. The Prime Minister also said he was happy to learn that India's ranking has improved in the Global Innovation Index to 52.

"Our programmes have created more technology business incubators in the last five years than in the previous 50 years. I congratulate our scientists for this achievement," he added.