Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.
The protesters, who gathered near the Sanskrit College Circle here, raised slogans glorifying Vishvesha Tirtha Swamiji of Pejawar Mutt and slammed the Dalit leaders, who raised voice against him.
Comments
Why is Pejawar seer, BJP and RSS hiding behind these sold out , so-called Muslims. why can't they come out on their own?
This is amusing. First ask pejawar seer why he keeps endorsing all the abuses and threats against the Muslims community during the \Hindu samajotsavas\" where he's the main organiser. Pejawar seer is the leading light of the VHP and Bajrang Dal. Please ask him to tell his group the VHP and Bajrang Dal to stop killing and raping Muslims (nowadays in the name of beef as well), then he can ask for their support. Thank you"
These are Muslims just in name. We need to know how much BJP & RSS has promised to give them for this publicity stunt. pejawar is behind the growth of the RSS and BD in the region, that has made life of Muslims miserable, and think they are 2nd class citizens. He was a leading light of the Babri demolition, and also behind the gau rakshaks who beat up and kill muslim traders . Instead of hiding behind these 'Muslims for rent', BJP and RSS should \protect\" Pejawar themselves, if they have any shame"
oh
Abdullah told good answer
Members of Udupi District Muslim Souharda Vedike (Bunch of Jokers in Udupi) , first of all you people protect yourself then talk about protecting the temple.
One of your hardcore Member (ANSAR) he himself is a THIEF, he had stolen gold at his own home in 2003, his father registered complaint in Udupi town police station. after investigation police arrested him.
Who is this Arif. Is he representative of Muslim community. I think such people led the protesters of sangh parivar to pelt stones to Masjids and shops/houses belongs to Muslims. I hope these ppl gave information to sangh parivars aboutthe Muslims who sacrifice animals. Is he really Arif and only a name given by sangh parivar to divide muslim community.
Muslims got high respect on Shri Krishna Matt . One should not cause any harm to mutt. Shri Pejawar Swamiji had gone all along from Udupi to Ayodhya to destroy the Babri Masjid.
Please dont call Muslims ... Call MRM sold outs... to cheddis
This Swamiji motivated the terrorist goons to demolish 5 century old Babri Masjid. thereby destroyed secularism in India. now needs the support of bone-licking munafiks
Let those mutt swamis chelas protect it....why muslims....go and protect yourself...from hell fire.....
Pejawar seer is known as as a hardcore advocate of RSS
well done. Thank you for staging protest and showing solidarity.. let's unite for good cause.
Dear Muslim Brother's.
First protect yourself from Hell fire.Later you can think of protecting other's. First learn about Islam then advise your Pejawar Sree about Islam and life after death.
Fear ALLAH,Obey Prophet Muhammed(pbuh).
It is a plan of pejawara.
his mutt has given some money to non practicing muslims (only name is muslim).
He want to devide dalits and muslims.
Mr. Arif how can say muslim community would be there to protect the thieves!!!???
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