Puttur, Jan 4: As many as 27 passengers travelling in a private bus escaped with minor injuries after it toppled and fell into a roadside trench at Amai near Perne on Mangaluru-Bengaluru national highway last night, police said on Saturday.
Police said that the driver of the Bengaluru-bond bus lost control over the vehicle while traversing through the narrow bridge at Amai.
The bus was damaged in the mishap.
Bantwal, Karnataka, May 29: Vitla Police have registered a case against four persons, including a Bajrang Dal leader, on charges of assaulting a boy and forcing him to chant 'Jai Shree Ram', video of which had gone viral on social media.
Police said on Friday that the accused have been identified as Bajrang Dal leader Dinesh, a resident of Kanyana, and two 16-year-old youngsters from Kolnadu village and a 17-year-old boy from Kanyana village. The victim of the assault has been identified as the first PUC student of Kudtumugaru.
On April 21, at around 11 am, four accused waylaid the boy's bike and started abusing him. They then dragged the boy to Kadumath High School grounds and assaulted and posed life threat. Besides, they forced him to chant ''Jai Shree Ram,'' he stated in the complaint.
Bengaluru, Jul 27: Andhra Pradesh and Karnataka crossed the grim milestone of one lakh Covid-19 cases while Tamil Nadu logged nearly 7,000 fresh infections for the third straight day on Monday as the sharp spike in recent weeks continued unabated in the southern states.
Kerala's tally inched toward the 20,000-mark and Telangana saw the total infection count beach the 55,000-mark while the cumulative cases rose to 2,872 in the tiny union territory of Puducherry as the six together added 20,629 fresh cases and their aggregate shot to 5.02 lakh.
A total of 291 deaths were reported on Monday from these states with Tamil Nadu accounting for the maximum of 77 closely followed by Karnataka with 74 fatalities, according to bulletins issued by respective states.
The cases have been rising in the region since last month when the lockdown norms were eased and thousands of people returned even as testing had been given a push.
The worst-hit was Andhra Pradesh where the Covid-19 count doubled in just eight days as the day's 6,051 cases pushed the tally to 1,02,349. It had crossed the 50,000-mark on July 20.
East Godavari district registered a high of 1,210 cases. After 16,86,446 tests were completed on Monday, the Covid-19 positivity rate in the state shot past the 6 per cent mark, a record high.
From 15,252 confirmed cases on July 1, the number swelled to the current level as every district in the state has been witnessing a severe surge in the pandemic.
The toll rose to 1,090 with 49 fresh deaths. The state now has 51,701 active cases after a total of 49,558 patients had recovered, a bulletin said.
Covid-19 cases in Karnataka spiralled to 1,01,465 as the state reported the biggest single-day spike of 5,324 new infections and 75 fatalities, taking the death toll to 1,953, the health department said.
The day also saw 1,847 patients getting discharged, taking the cumulative recoveries to 37,685.
Tamil Nadu reported highest single-day spike of 6,993 cases, taking the tally to 2,20,716 while 77 deaths propelled the toll to 3,571.
The state has added 45,038 cases since last Monday while the active cases stood at 54,896 and recoveries touched 1,62,249, including 5,723 people discharged today.
Chennai accounted for 95,857 cases of the state's tally.
In Kerala, at least 43 health workers were among the 702 people who tested positive while 745 others recovered, as the state's total infection tally touched 19,727.
The death toll climbed to 63 with two more fatalities from Kozhikode and Kottayam districts, while 9,611 people were presently under treatment, Chief Minister Pinarayi Vijayan said.
A total of 10,054 patients have recovered so far and over 1.55 lakh people were under observation, he told reporters in Thiruvananthapuram.
Telangana's total infection count rose to 55,532 with the addition of 1,473 cases, including 506 from Greater Hyderabad Municipal Corporation (GHMC) areas, a government bulletin said on Monday, providing data as of 8 pm on Sunday.
With eight more deaths, the Covid-19 toll in the state rose to 471. The death rate was 0.85 per cent as against 2.3 per cent in the country, it said.
As many as 42,106 people have recovered from the infection so far, while 12,955 were under treatment.
Puducherry logged 86 new cases, pushing the overall tally to 2,872 and the toll increased to 43 with three more deaths. It has 1,109 active cases, an official statement said.
Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.
Comments
this is one of the important case that now seen to be increasing these days. and one of the most problem that is faced and had has to be found a solution is overspeeding by bus driving which have resulted in enomours numbers of accidents with negligence of passengers lifes inside the bus. passengers safety and lifes are not given value anymore. and another important factor is overspeeding in humps which have resulted in backbone injuries in high number of passengers
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