New AI system can monitor your sleep with radio waves

Agencies
August 8, 2017

Boston, Aug 8: Scientists have developed a new artificial intelligence system that can monitor a person's sleep using ambient radio waves, without sensors attached to the body.

The device analyses the radio signals around the person and translates those measurements into sleep stages - light, deep, or rapid eye movement (REM).

Researchers at Massachusetts Institute of Technology (MIT) and Massachusetts General Hospital in the US have devised a new way to monitor sleep stages without sensors attached to the body.

"Imagine if your Wi-Fi router knows when you are dreaming, and can monitor whether you are having enough deep sleep, which is necessary for memory consolidation," said Dina Katabi, professor at MIT, who led the study.

"Our vision is developing health sensors that will disappear into the background and capture physiological signals and important health metrics, without asking the user to change her behaviour in any way," Katabi said.

Researchers had previously developed radio-based sensors that enable them to remotely measure vital signs and behaviours that can be indicators of health.

These sensors consist of a wireless device, about the size of a laptop computer, that emits low-power radio frequency (RF) signals.

As the radio waves reflect off of the body, any slight movement of the body alters the frequency of the reflected waves.

Analysing those waves can reveal vital signs such as pulse and breathing rate. "It's a smart Wi-Fi-like box that sits in the home and analyses these reflections and discovers all of these changes in the body, through a signature that the body leaves on the RF signal," Katabi said.

The approach could be useful for monitoring sleep, which is currently done while patients spend the night in a sleep lab hooked up to monitors such as electroencephalography (EEG) machines.

"We have this technology that, if we can make it work, can move us from a world where we do sleep studies once every few months in the sleep lab to continuous sleep studies in the home," said Mingmin Zhao, an MIT graduate student.

To achieve that, researchers had to come up with a way to translate their measurements of pulse, breathing rate, and movement into sleep stages.

Recent advances in artificial intelligence have made it possible to train computer algorithms known as deep neural networks to extract and analyse information from complex datasets, such as the radio signals obtained from the researchers' sensor.

However, these signals have a great deal of information that is irrelevant to sleep and can be confusing to existing algorithms.

The MIT researchers had to come up with a new AI algorithm based on deep neural networks, which eliminates the irrelevant information.

Using this approach in tests of 25 healthy volunteers, the researchers found that their technique was about 80 per cent accurate, which is comparable to the accuracy of ratings determined by sleep specialists based on EEG measurements.

"Our device allows you not only to remove all of these sensors that you put on the person, and make it a much better experience that can be done at home, it also makes the job of the doctor and the sleep technologist much easier," Katabi said.

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Agencies
January 26,2020

High-protein diets may help people lose weight and build muscle, but there is a downside to it --a greater heart attack risk. Researchers now report that high-protein diets boost artery-clogging plaque.

The research in mice showed that high-protein diets spur unstable plaque -- the kind most prone to rupturing and causing blocked arteries.

More plaque buildup in the arteries, particularly if it's unstable, increases the risk of heart attack.

"There are clear weight-loss benefits to high-protein diets, which has boosted their popularity in recent years," said senior author Babak Razani, associate professor at Washington University School of Medicine in St. Louis, Missouri.

"But animal studies and some large epidemiological studies in people have linked high dietary protein to cardiovascular problems. We decided to take a look at whether there is truly a causal link between high dietary protein and poorer cardiovascular health," Razani added.

The researchers studied mice who were fed a high-fat diet to deliberately induce atherosclerosis, or plaque buildup in the arteries.

Some of the mice received a high-fat diet that was also high in protein. And others were fed a high-fat, low-protein diet for comparison.

The mice on the high-fat, high-protein diet developed worse atherosclerosis -- about 30 per cent more plaque in the arteries -- than mice on the high-fat, normal-protein diet, despite the fact that the mice eating more protein did not gain weight, unlike the mice on the high-fat, normal-protein diet.

"A couple of a scoop of protein powder in a milkshake or smoothie adds something like 40 grams of protein -- almost equivalent to the daily recommended intake," Razani said.

"To see if protein has an effect on cardiovascular health, we tripled the amount of protein that the mice receive in the high-fat, high-protein diet -- keeping the fat constant. Protein went from 15 per cent to 46 per cent of calories for these mice".

Plaque contains a mix of fat, cholesterol, calcium deposits and dead cells. Past work by Razani's team and other groups has shown that immune cells called macrophages work to clean up plaque in the arteries.

But the environment inside plaque can overwhelm these cells, and when such cells die, they make the problem worse, contributing to plaque buildup and increasing plaque complexity.

"In mice on the high-protein diet, their plaques were a macrophage graveyard," Razani informed.

To understand how high dietary protein might increase plaque complexity, Razani and his colleagues also studied the path protein takes after it has been digested -- broken down into its original building blocks, called amino acids.

"This study is not the first to show a telltale increase in plaque with high-protein diets, but it offers a deeper understanding of the impact of high protein with the detailed analysis of the plaques," said Razani.

"This work not only defines the critical processes underlying the cardiovascular risks of dietary protein but also lays the groundwork for targeting these pathways in treating heart disease," he added.

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News Network
February 26,2020

New York, Feb 26:  A new wearable sensor that works in conjunction with artificial intelligence (AI) technology could help doctors remotely detect critical changes in heart failure patients days before a health crisis occurs, says a study.

The researchers said the system could eventually help avert up to one in three heart failure readmissions in the weeks following initial discharge from the hospital and help patients sustain a better quality of life.

"This study shows that we can accurately predict the likelihood of hospitalisation for heart failure deterioration well before doctors and patients know that something is wrong," says the study's lead author Josef Stehlik from University of Utah in the US.

"Being able to readily detect changes in the heart sufficiently early will allow physicians to initiate prompt interventions that could prevent rehospitalisation and stave off worsening heart failure," Stehlik added.

According to the researchers, even if patients survive, they have poor functional capacity, poor exercise tolerance and low quality of life after hospitalisations.

"This patch, this new diagnostic tool, could potentially help us prevent hospitalizations and decline in patient status," Stehlik said.

For the findings, published in the journal Circulation: Heart Failure, the researchers followed 100 heart failure patients, average age 68, who were diagnosed and treated at four veterans administration (VA) hospitals in Utah, Texas, California, and Florida.

After discharge, participants wore an adhesive sensor patch on their chests 24 hours a day for up to three months.

The sensor monitored continuous electrocardiogram (ECG) and motion of each subject.

This information was transmitted from the sensor via Bluetooth to a smartphone and then passed on to an analytics platform, developed by PhysIQ, on a secure server, which derived heart rate, heart rhythm, respiratory rate, walking, sleep, body posture and other normal activities.

Using artificial intelligence, the analytics established a normal baseline for each patient. When the data deviated from normal, the platform generated an indication that the patient's heart failure was getting worse.

Overall, the system accurately predicted the impending need for hospitalization more than 80 per cent of the time.

On average, this prediction occurred 10.4 days before a readmission took place (median 6.5 days), the study said.

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Agencies
March 27,2020

New Delhi, Mar 27: The Centre has restricted sale and distribution of "hydroxychloroquine" declaring it as an essential drug to treat the COVID-19 patients and meet the requirements of emergency arising due to the pandemic.

The Ministry of Health and Family Welfare on Thursday made the announcement making it clear that the order "shall come into force on the date of its publication in the official Gazette".

In the order, the government declared that the Central government is "satisfied that the drug hydroxychloroquine is essential to meet the requirements of emergency arising due to pandemic COVID-19 and in the public interest, it is necessary and expedient to regulate and restrict the sale and distribution of the drug 'hydroxychloroquine' and preparation based thereon for preventing their misuse".

"Now, therefore, in exercise of the powers conferred by Section 26B of the Drugs and Cosmetics Act, 1940 (23 of 1940), the Central government hereby directs that sale by retail of any preparation containing the drug Hydroxychloroquine shall be in accordance with the conditions for sale of drugs specified in Schedule H1 to the Drugs and Cosmetics Rules, 1945."

The order came at a time when the novel coronavirus claimed 16 lives and infected over 600 people across India.

The announcement regarding ban of sale and distribution of the drug was made by the government earlier but it issued an official Gazette notification on Thursday signalling that hydroxychloroquine -- an anti-Malaria drug -- will work as a medicine for treating coronavirus infected patients as well.

Recently, the national task force for COVID-19 constituted by Indian Council for Medical Research (ICMR) has recommended hydroxy-chloroquine as a preventive medication.

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