Stop Civic Tiger operation against street vendors'

Bengaluru, Apr 1: After fake sanitisers and masks, Central Crime Branch (CCB) police have busted another racket and seized fake thermometers worth Rs 8 lakh, it said in a statement on Wednesday.

Based on credible information, police conducted the raid on Prajval Surgical and Scientific store located on the first floor of a commercial building in the first block, Rajajinagar. They arrested store manager Keshavan N, 32, a resident of Kurubarahalli.

The police have seized 70 fake infrared forehead thermometers and 60 batteries used in these thermometers. They were worth around Rs 8 lakh as per the price they charged customers for each thermometer.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Feb 25: Opteamix LLC (Opteamix), a digital technology firm, announced today that they have been awarded as a 'Dream Company to Work For' by the World HRD Congress.

Opteamix was ranked 11th in this category which had companies from multiple industries across the globe vying for the title.

In addition to the Dream Company ranking, Opteamix was also recognized for its innovative HR practices and Corporate Social Responsibility practices. The event took place at Taj Land's End in Mumbai on February 16.

Opteamix presented their concept 'Happiness at Work - When Culture drives Performance' that elaborated upon the methodology behind the enhancement of employee happiness.

"We have taken a holistic approach to help our people stay happy at work. While we knew that EQ and IQ were critical to the growth of people, we also believed that it is the Spiritual Quotient (SQ) which our in-house NGO - Right To Live caters to, that helps our people experience next-level career growth," said Varsha Dubey, Lead - Happiness and Learning Activator, while explaining the theory behind the happiness at work during the 30-min presentation before delegates from 65 countries.

"We have empowered our people by equipping them with the right set of tools to help them excel in their performance based on OKR (Objectives and Key Results), CFR (Communication, Feedback, and Review) and Competency Mapping. The optimum blend of these performance management tools has resulted in making a significant impact on the careers of our people and therefore, happy people and 100 per cent innovation and efficiency at work," added Shalu Priya - Director, People Experience.

Now in its 28th year, the World HRD Congress presents awards to organizations that promote innovative human resources practices. The award categories include leadership, talent management, employer branding, training and development, employee engagement, and more.

In the recent past, Opteamix had been recognized for its commitment to employee excellence with numerous awards and recognitions including 'Dream Companies to Work for' in 2017 and 2018.

World HRD Congress is billed as South Asia's largest HR event, featuring an eminent panel on international and local speakers from across public and private sectors.

The conference serves as a platform for the HR fraternity to deliberate on the insights, initiatives and implications of people management practices. The theme this year 'Happiness at work', recognized individuals and companies for their exceptional people management practices.

"We strongly believe in creating a culture of happiness at Opteamix. To us, happiness is as important as revenue and profits. The culture of happiness has been the Opteamix way of life since inception, which has led us to achieve our ultimate goals - higher career growth for all members and richer customer experience," said Raghurama Kote - Founder and COO of Opteamix, on being asked what a happy organization meant to him.