Global HIV vaccine closer to reality

October 25, 2013

Global_HIVWashington, Oct 25: Scientists have found that bioinformatically optimised HIV vaccine antigens may help design a global HIV vaccine.

A scientific team led by Beth Israel Deaconess Medical Center (BIDMC) conducted the study in monkeys.

"A global HIV vaccine would offer major biomedical and practical advantages over most other HIV vaccine candidates, which are limited to certain regions of the world," said lead author Dan H Barouch, Professor of Medicine at Harvard Medical School.

"To our knowledge, this study represents the first evaluation of the protective efficacy of a candidate global HIV antigen strategy in nonhuman primates," said Barouch.

Researchers demonstrated for the first time that mosaic HIV vaccine antigens can afford partial protection in rhesus monkeys against challenges with a stringent simian-human immunodeficiency virus.

These mosaic vaccine antigens have been developed for optimal immunologic coverage of global HIV diversity.

Barouch and his team studied the immunogenicity of HIV mosaic Env/Gag/Pol antigens administered to monkeys using viral vectors. Env, Gag, and Pol are three major HIV proteins.

After immunisation, the monkeys were repetitively exposed to multiple simian-human immunodeficiency virus challenges and the investigators evaluated the ability of the vaccines to block infection.

Although most animals immunised with the mosaic HIV vaccine became infected by the end of the study, the researchers observed an 87 to 90 per cent reduction in monkeys' probability of becoming infected each time they were exposed to the virus.

In contrast, monkeys that received sham vaccines became infected more quickly.

"These findings indicate that these optimised vaccine antigens can afford partial protection in a stringent animal model," said Barouch.

The investigators found that the immunised monkeys mounted antibody responses against diverse strains of HIV noting, "protection was dependent on several different types of antibody responses, suggesting that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralise viruses."

The monkeys also mounted cellular immune responses to multiple regions of the virus.

"These data suggest a path forward for the development of a global HIV vaccine and give us hope that such a vaccine might indeed be possible," said Barouch.

"We are planning to advance this HIV vaccine candidate into clinical trials next year," he added. The study was published in the journal Cell.

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News Network
March 5,2020

Mar 5: The Kerala government has given its nod to a proposal aimed at encouraging students aged between 18 and 25 years to take up part-time jobs while pursuing education so as to help them gain work experience and hone their skills.

The government has decided to accept the proposal as a policy decision at the Cabinet meeting held on Wednesday, an official press release said.

The aim is to ensure that in a fiscal, 90 days of work is assured for students in government departments, local body organisations, PSUs and private companies.

This will help in developing a work culture among students.

Honorariums will be given to students by the organisations employing them part-time, the release said.

Students aged between 18 and 25 years will be permitted to become part of the scheme which will help them to gain work experience and hone their skills, the release added.

In another decision, the government decided to release Rs 26 crore from the Chief Minister's disaster relief fund for providing compensation to farmers who suffered crop loss during the 2018 floods.

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News Network
March 29,2020

Thiruvananthapuram, Mar 29: Kerala Chief Minister Pinarayi Vijayan on Saturday expressed his concern over the ''non-cooperation from the Karnataka Government in removing the roadblocks erected by them in the roads bordering Malapuram district''.

Addressing a press conference at the Government Secretariat, the Chief Minister said, "Karnataka has not heeded to our request to remove the roadblocks. I have been trying to contact their Chief Minister B S Yeddyurappa but not able to reach him."

"We have briefed the Union Minister D V Sadananda Gowda and he has offered to resolve the issue. Our Chief Secretary has also briefed the Central Cabinet Secretary and we expect a resolution soon," he added.

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News Network
June 18,2020

New Delhi, Jun 18: Prime Minister Narendra Modi on Thursday launched the auction process for 41 coal blocks for commercial mining, a move that opens India’s coal sector for private players, and termed it a major step in the direction of India achieving self-reliance.

Launching the auction of mines for commercial mining, that is expected to garner ₹33,000 crore of capital investment in the country over next five to seven years, the Prime Minister said India will win the coronavirus war and turn this crisis into an opportunity, and the pandemic will make India self-reliant.

The launch of the auction process not only marks the beginning of unlocking of the country’s coal sector from the lockdown of decades , but aims at making India the largest exporter of coal, the Prime Minister said.

Presently, despite being the world’s fourth largest producer, he said India is the second largest importer of the dry-fuel.

“Allowing private sector in commercial coal mining is unlocking resources of a nation with the world’s fourth-largest reserves,” he pointed out.

Major scams had taken place in coal action earlier, but the system has been made “transparent” now, the Prime Minister said lambasting past policies of keeping the sector closed.

Mr. Modi said that this auction process will result in major revenues to states and create employment besides developing the far-flung areas.

The commencement of auction process of these blocks, part of the series of announcements made under ‘Atmanirbhar Bharat Abhiyan’, is likely to contribute ₹20,000 crore revenues annually to the state governments.

In line with the Prime Minister’s self-reliance call, the aim behind the auction process is to achieve self-sufficiency in meeting energy needs and boosting industrial development.

The government has taken an important decision to open up coal and mining sector to competition, capital and technology, he said.

Coal and Mines Minister Pralhad Joshi, who was also be present during the launch event, said ₹50,000 crore is being invested in the sector to jack up India’s coal output to 1 billion tonne.

With a view to achieve self-reliance in the coal sector, the Ministry of Coal in association with FICCI launched the process of auction of 41 coal mines under the provisions of Coal Mines (Special Provisions) Act and Mines and Minerals (Development and Regulation) Act.

Upon attainment of peak rated capacity of production of 225 million tonnes (MT), the government said, these mines will contribute about 15% of the country’s projected total coal production in 2025-26.

It will also lead to employment generation for more than 2.8 lakh people — direct employment to approximately 70,000 people and indirect employment to approximately 2,10,000 people, as per the government.

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