No compromise on principles, says Congress leader on govt

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Puttur, June 19: A 32-year-old woman in Puttur taluk of Dakshina Kannada district died due to complications caused by dengue yesterday.

The deceased is Naseema (32), wife of Nazeer Master, a resident of Parpunja village in the taluk.

She was not well for past few weeks and she was diagnosed with dengue fever with chills a week ago.

Initially she underwent treatment at a hospital in Puttur. After her condition worsened, she was shifted to a private hospital in Deralakatte.

However, she breathed her last without responding to any treatment last night.

Naseema is the second victim of the mosquito-borne infection in Puttur taluk this month. Last week, dengue had claimed the life of a woman in Bettampady village in the same taluk.

Mangaluru, Feb 10: Sandeep Malani has been of lately winning back to back awards at various events and film festivals. Being an actor, he has won 3 Best Actor awards (2 for his gripping performance in the Kannada feature film, Mookavismitha, directed by Gurudutt Sreekanth and one award for his multi faceted performance in the short film, Nishyabda Nishi directed by his son Silver). These awards were honored at the Indian Cine Film Festival in Mumbai and Karunadu Kannada Rathna Award in Bengaluru.

He also won an award for his woman empowerment film, Sulige Sikkidaaga in Pune, while his musical documentary on Sridevi titled SrideviBaaz won him two awards at Pune and Kolhapur International film festivals. His other short film on transgender Mamta (Maternal Love) won the Audience Awards in USA.

Very recently he was honored by the Filmaholic Foundation in Bengaluru for being a successful short film maker with two Kannada films Jo Jo Laali and Sulige Sikkidaaga, both featuring award winning actress Kalpana Pandit, winning multiple awards and making news at International Film Festivals. This honor was given at the Karnataka Youth International Short Film Festival.

With donning so many feathers of awards in his hat, he recently bagged the most prestigious one; that being receiving the Award for Best Feature Film shot on Mobile for his film ‘Maa – Yeh CineMaa Hai’ shot on iPhone at the 1st ever IMFF India (International Mobile Film Festival India 2020) held at World Trade Center, Mumbai on 8th February.

With a whole lot short films in the category and barely few feature films in the Feature Film Category, Malani verged out to be the winner as his Hindi film was a complete family entertainer that of 5 songs, sentiment value, and a wholesome entertainer with 100 artists working in the film that consists of stage and television actors, newcomers, models and common people. The film starred Sandeep’s family members playing important roles. His mother, Meena Malani (playing the title role), wife Reshma Malani (playing one of the lead actress) and son Silver Malani (playing an important character). The cast includes Mahesh Dulam, Anita Dulam, Ranjeet Jha, Bharath Lakshmikanth, Mahendra Pandey, Vishal Digani, Akash Hora, Shuba Raksha, Sanjukta Ghosh, Sharanya Kaur, Varsha Acharya, Kkewal Sharma, Anant Joshi, Vivek Punjabi, Valerian Menezes, Nigel Pereira. Veteran actresses Sarojini Shetty, Deepali Khambadkone, Vinny Fernandes also features in the film while Kalpana Pandit, Sudha Chandran, Sonal Monteiro, Adaa Khan and others give a social message on mother, womanhood and empowerment.  The film has been jointly produced by RKJ Film Productions, The Studio Agency and Malani Talkies.