Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
hahaha muslims always find problem where they are ... In arab world they find enemy in the name of Israel , in west they scream that chummag ge gummah madthavre americans and christains antha ... bosnia dalli serbians mele ... burma dalli namma buddhist mele ... india dalli RSS mele ... hane baraha ashte ... no islamic country is peaceful as it is full of terrorists . Iran is an exception as they are shia ... 99.99% terror crimes , frauds , smugling , rapes are done by one particular community only ... still they scream they innocent anthe , mullahs give us a break ... we know what you are doing ... Hindus are well aware of what jihadist did for their culture , how indian women were raped and places of worships were destroyed . yaavano helidnthanthe RSS mukhta bharatha madthini antha ... adakke chummah gang namgobba leader sikkavne , madiji ge manja tinsona antha scheme haaktha idave ... hahaha ... RSS is not a local organisation ,it has so powerful lobby and very vast network across the globe ..next only to jewish lobby now . jewish and Indian lobby work together ...RSS is 100 times more stronger than these scums imagine .. nothing wrong in questioning muslims and if they are not found guilt send them out ... india must be free from terrorism ... so NIA must watch madrassas which are symbol of terrors and seminaries , which is a breeding ground for jihadist acts ...jai ho israel .. jai ho india ... long live Indo israel relationship ... death to enemies of israel and india ... hara hara modi .. jai jai modi ... jihadi gala pinkaan ge mirchi biddu ice mele koorlikke horadtha ive antha kanuthe ... yakku baba ... bholo bharath mata ki jai ... i heard one jihadi lady , pinkaan nalli 1 kg gold madikondu bandu namma police kaili sikki haakondavlanthe howda mullah gala .. hahahahha
Maulana thariq jameel is a scholar, his speech has changed many lives all over the world, and his speech CDs are commonly available in India and in gulf countries.
Kumar, if Muslims threw you out from India...we would not have seen you talking like this here in CD....it is because of your kind of people our country is not progressing...facing lot of problems now and then....Burma will suffering because of their wrong doing....
Muslims are not terrorists....RSS made them scafegoats
We Indians must stand up and voice and war against terrorists and terrorism. I salute Bihar CM Nithish Kumar's call for free RSS.
If we get rid of RSS then there will be peace everywhere in India.
RSS is the root cause of terrorism.
@ VENKI MANGALORE
YA YA BJP DPING THE WORK PROPERLY YES U R RIGHT
THEY TRING TO MAKE COW AS MOTHER AND BAN IN INDIA
BAGWATH GEETHA TO ANNOUNCE NATION HOLLY BOOK
THESE THEY DOING WORK RIGHT NOW
I feel sympathy for those CD anti muslim viewers who try to sling the mud on muslims stored in their backyard
@ KUMAR MANGALORE .
MIND UR WORDS.. DONT TALK AGAINST THE MUSLIM
TALK AGAINST THE TERRORISM
NEED TO CATCH VHP WE WILL GET THE PURE LINK...
Add new comment