Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
I think kateel had good new year celebration along with mithun rai.... free alcohol was supplied by mithun rai.....what you say guys????? lagta hai daaru kuch bohat hi zyaada hogayi thi raat me....daaru ka nasha utra nahi hoga....isliye agle din subah aake kateel ne apni dil ki baat keh di.....wo kehte hai na daaru ke nashe me aadmi ke muh se sach nikalta hai
Think twice before u speak, is a famous dialogue which clearly suits Nalini Kumari Kateel.. Mike mila tho pagal bhi gaane lagta hey,,
He is not fit for MP.......should be removed.....
Nalin is lying that he was not well. He uttered what bjp and sanghis have planned. Nothing can be hidden for a long time. this is hidden agenda of sanghis to create trouble in karnataka and costal districts in particular. Police should arrest him under goonda act. He should be removed from MP post as he is unfit for this responsible position. Suprement Court should order central Govt to take notice of this dangerous statement from an MP and remove him from this post. In case Nalin is mentally sick, admit him in a mental hospital.
for instance if this was happened from one of our muslim brother, what would be the reaction and action from these sanghis????? even from chaddi police dept......
ha now we came to know that you are bad mental mp of our dk dist. shame on you. you must resign immediately.
New year night \ raathre paad dina onchooru jaasthiathund\" - mallajjappa powad.
Ancha namma modi 15 lakh niklena bank gu paadwe panthijja..... Anchane indula..
Thoo paadare inbe daane lankeda hanumanthena?"
Hahaha...pukkele...
Typical coward sanghi...
The nation wants to know whether you are really not well or the frog inside well?
No need to give clarification just put this man behind bars. Useless MP
Pradeepji, NOT Wenlock, Kankanady Permanently.
Such goondas are fit to be encountered ....
Yes true he is not well... this all unstable people belongs to BJP/RSS, They dont know what they are speaking after all, all are the followers of chaiwala, what we can expect from this RSS goondas...this marle minister even dont know to speak in parliment, he drinks spit twice before he delivers a word
If he is unwell, admit him to Wenlock
This is the fact and sanghis real mentality. Now he may accept his threatening to set fire his own constituency, message is out in public.
Every anti-national will say the same thing when press conference even Thogadia....Shame on you as a MP of our beloved Dakshina Kannada. Did the people elect you to disturb the area & set fire .. Thooo ninna....
Anna kadle baipinanda thoo malpode, E thoo malpu bokk kadle baipundu.....
why didnt police arrest him, he is enticing people to create violence, why no suo motto on him.
such people should be booked under goonda act
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