Now, climate-based system could predict dengue spread in India

Agencies
September 3, 2017

London, Sept 3: Scientists have developed a system that can predict the spread of dengue in different parts of India, based on climatic factors, an advance that may help take preventive measures against the deadly infection.

Researchers from the University of Liverpool in the UK identified the climatic risks for dengue disease outbreaks in different climatic zones in the country through the states of Punjab, Haryana, Rajasthan, Gujarat and Kerala. The team, in collaboration with researchers from Indian Institute of Chemical Technology (IICT) in Hyderabad and National Institute of Pharmaceutical Education and Research

(NIPER) in Guwahati, focused on changes in a factor called 'extrinsic incubation period (EIP)' of the dengue virus by taking into account daily and monthly mean temperatures in these areas.

EIP is the time taken for incubation of the virus in the mosquito. During this period, after the mosquito draws a virus-rich-blood meal, the virus escapes the gut, passes through the mosquito's body and reaches it salivary glands. Once this happens, the mosquito is infectious and capable of transmitting the virus to a human host. It has been found that climatic conditions play an important role in EIP.

Lower temperatures (17-18 degrees Celsius) result in longer EIPs thereby leading to decreased virus transmission. With increasing temperatures, feeding increases because of enhanced metabolism of the mosquito, leading to shorter EIPs. Even a five-day decrease in the incubation period can hike transmission rate by three times, and with an increase in temperature from 17 to 30 degrees Celsius, dengue transmission increases fourfold.

However, a further increase in temperature beyond 35 degrees Celsius is detrimental to the mosquito survival. Researchers observed that except for Gujarat which comprises of arid regions, there was a strong correlation between rainfall and dengue disease burden.

They propose an increase in breeding grounds for mosquitoes as a major reason for this finding. The study found that Kerala being warm (temperature range 23.5-30 degrees Celsius) and wet and with short EIPs (9-14 days) experiences the highest number of dengue cases.

It has been found that EIP is the shortest during the monsoon season in most states and therefore there is an enhanced risk of dengue during this time. It is important to take into account the dynamic EIP estimates in different regions in assessing disease burden. "This climate-based dengue forecasting model could help health authorities to assess the disease intensity in a geographic region, based on that they can plan disease control operations well in advance and optimise the use of resources meticulously," said Srinivasa Rao Mutheneni of IICT, who led the study.

Changes in temperature affecting the extrinsic incubation period of the virus, future changes in the climate might have a substantial effect on dengue and other vector-borne disease burden in India.

"Though such methods are in vogue for disease control operations, we are still in the initial stages of implementation of such strategic control methods," Rao said. "Factors such as population density and migration also need to be included for future risk assessment studies," he said.

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Agencies
July 8,2020

Scientists have designed a “catch and kill” air filter which they say can trap the novel coronavirus and neutralise it instantly, an invention that may reduce the spread of COVID-19 in closed spaces such as schools, hospitals and health care facilities, as well as public transit environments like airplanes.

According to the study, published in the journal Materials Today Physics, the device killed 99.8 per cent of the novel coronavirus, SARS-CoV-2, in a single pass through its filter. It said the device, made from commercially available nickel foam heated to 200 degrees Celsius, also killed 99.9 per cent of the spores of the deadly bacterium Bacillus anthracis which causes the anthrax disease.

“This filter could be useful in airports and in airplanes, in office buildings, schools, and cruise ships to stop the spread of COVID-19,” said Zhifeng Ren, a co-author of the study from the University of Houston (UH) in the US.

“Its ability to help control the spread of the virus could be very useful for society,” Ren added.

The researchers said they are also developing a desk-top model for the device which is capable of purifying the air in an office worker’s immediate surroundings. According to the scientists, since the virus can remain in the air for about three hours, a filter that could remove it quickly was a viable plan, and with businesses reopening across the world, they believe controlling the spread in air conditioned spaces was urgent.

The study noted that the novel coronavirus cannot survive temperatures above 70 degrees Celsius, so by making the filter temperature far hotter — about 200 degree Celsius, the researchers said they were able to kill the virus almost instantly.

Ren said the nickel foam met several key requirements. “It is porous, allowing the flow of air, and electrically conductive, which allowed it to be heated. It is also flexible,” the researchers noted in a statement.But they added that nickel foam also had low resistivity, making it difficult to raise the temperature high enough to quickly kill the virus.

The researchers said they solved this problem by folding the foam, connecting multiple compartments with electrical wires to increase the resistance high enough to raise the temperature as high as 250 degrees Celsius. By making the filter electrically heated, rather than heating it from an external source, they said the the amount of heat that escaped from the filter is minimised, allowing air conditioning to function with very low strain.

When the scientists built and tested a prototype for the relationship between voltage/current and temperature, they said it satisfies the requirements for conventional heating, ventilation, and air conditioning (HVAC) systems, and could kill the coronavirus.

“This novel biodefense indoor air protection technology offers the first-in-line prevention against environmentally mediated transmission of airborne SARS-CoV-2, and will be on the forefront of technologies available to combat the current pandemic and any future airborne biothreats in indoor environments,” said Faisal Cheema, another co-author of the study from UH.

The researchers have called for a phased roll-out of the device, “beginning with high-priority venues, where essential workers are at elevated risk of exposure.” They believe the novel device will both improve safety for frontline workers in essential industries and allow nonessential workers to return to public work spaces.

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Agencies
February 23,2020

Los Angeles, Feb 23: According to researchers, if administered quickly, a common medication that reduces bleeding could be a treatment for bleeding stroke.

The Spot Sign and Tranexamic Acid on Preventing ICH Growth - Australasia Trial (STOP-AUST) was a multicenter, prospective, randomized, double-blind, placebo-controlled, phase 2 clinical trial using the antifibrinolytic agent tranexamic acid in people with intracerebral hemorrhage (ICH).

ICH is a severe form of acute stroke with few treatment options.

Tranexamic acid is currently used to treat or prevent excessive blood loss from trauma, surgery, tooth removal, nosebleeds and heavy menstruation. For this study, one hundred patients with active brain bleeding were given either intravenous tranexamic acid or placebo within 4.5 hours of symptom onset.

Researchers analyzed brain CT scans taken during the 24-hour period after treatment with tranexamic acid or placebo.

Researchers found a trend towards reduced hemorrhage expansion in the group treated with tranexamic acid, especially in those treated within 3 hours of the brain bleed. However, this trend was not statistically significant. The finding was consistent with previous research using the medication.

"Further trials using tranexamic acid are ongoing and focusing on ultra-early treatment - within 2 hours. 

This is where the greatest opportunity for intervention appears to be. Tranexamic acid is inexpensive, safe and widely available. Our results and others provide great impetus for further, focused research using this treatment," Nawaf Yassi said.

Larger trials focused on patient outcomes are required for this therapy to enter routine clinical practice.

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Agencies
January 4,2020

Washington D.C., Jan 3: A new study has found out that diet significantly affects the mental health and well being of an individual.

The study was published in the journal European Neuropsychopharmacology.

"We have found that there is increasing evidence of a link between a poor diet and the worsening of mood disorders, including anxiety and depression. However, many common beliefs about the health effects of certain foods are not supported by solid evidence," said the lead researcher, Professor Suzanne Dickson.

According to the researchers, the link between diet and mental health can be firmly established in certain cases like that of the ability of a ketogenic diet being helpful for children with epilepsy and the impact of vitamin B12 deficiency on poor memory, depression and fatigue.

"With individual conditions, we often found very mixed evidence. With ADHD for example, we can see an increase in the quantity of refined sugar in the diet seems to increase ADHD and hyperactivity, whereas eating more fresh fruit and vegetables seems to protect against these conditions," said Dickson

But there are comparatively few studies, and many of them don't last long enough to show long-term effects," added Dickson.

The study further concludes that some food items can be associated with treatment and the betterment of certain mental health conditions.

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