Oops! France may face sperm shortage under proposed IVF rules

Agencies
September 24, 2019

Paris, Sept 24: France risks a shortage of frozen sperm if lawmakers approve new legislation that allows single women and lesbian couples access to in-vitro fertilisation (IVF) and abolishes the right of sperm and egg donors to keep their identities secret, clinicians said.

Lawmakers in the country's National Assembly on Tuesday start debating a bioethics bill that unwinds some of western Europe's strictest rules governing medically-assisted pregnancies, a campaign promise of President Emmanuel Macron.

Under existing law in France, IVF is available only to opposite-sex couples, and only for reasons of infertility or the risk of transmission of a disease or medical condition to the child or either parent.

Health Minister Agnes Buzyn forecasts a roughly two-thirds increase in demand for IVF procedures, with an extra 2,000 women annually registering for treatment.

Couples already wait an average of 12 months from registration to their first attempt at IVF. Clinicians at France's network of public sperm banks (CECOS) said the supply of cryopreserved sperm only just meets demand.

Moreover, they predict lifting donor anonymity could prompt three-quarters of registered male and female donors to deny clinics the use of their sperm and eggs under the new rules.

"To say 'everything is going to be ok' would be burying your head in the sand," Nathalie Rives, president of the CECOS federation, told Reuters.

"There will be a period of instability, with increased demand and the need to recruit new donors. We don't know how long this instability will last and whether there will be a shortage."

The bioethics bill, which would also allow women to freeze their eggs for non-medical reasons to enhance their chances of having children, is Macron's first major societal reform.

Medically assisted reproduction - such as IVF - is widely available to all women in countries such as Britain, Belgium, Spain. But in France, it has fed into a broader debate about the commercialization of healthcare and gay rights.

"The right to know one’s origins is a vital right, a fundamental right,” said Arthur Kermalvezen, 35, who turned to DNA tests to track down his biological father and has campaigned for the lifting of anonymity.

The legalisation of gay marriage in France six years ago sparked massive street protests even though the influence of the Catholic Church was thought to be in decline.

In a sign France has become more socially liberal, polls show a majority of French people back the bioethics reform.

Professor Rachel Levy, who runs the CECOS centre at the Tenon Hospital in Paris, said donor anonymity would remain in place for 13 months after the legislation comes into effect in an effort to help sperm banks build up stocks.

There would then be a second phase during which existing donors would say if they consent to their cryopreserved sperm being used under the new rules. The samples of those who refuse will be destroyed later.

"It's a challenging situation," Levy said.

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Agencies
March 28,2020

Canadian researchers are developing a DNA vaccine for SARS-CoV-2, the coronavirus that causes COVID-19 and has currently infected nearly 5,00,000 people worldwide and crippled the global economy.

Entos Pharmaceuticals, a health-care biotechnology company headed by a University of Alberta researchers, develop new therapeutic compounds using the company's proprietary drug-delivery platform and has begun manufacturing vaccine candidates against the novel coronavirus.

"Given the urgency of the situation, we can have a lead candidate vaccine within two months. Once we have that it's a race to get it into clinical trials," said John Lewis, CEO of Entos and a Professor at the University of Alberta in Canada.

Lewis said in comparison to a traditional vaccine, DNA-based vaccines hold several advantages.

Nucleic acids are introduced directly into the patient's own cells, causing them to make pieces of the virus--tricking the immune system into mounting a response without the full virus actually being present, the researcher said.

According to the company, the approach is recognised as being easier to move into large-scale manufacturing, offers improved vaccine stability and works without needing an infectious agent.

In the current absence of a vaccine for COVID-19, several companies around the world are mounting efforts to begin similar work.

The first clinical trial using a DNA-based vaccine developed by Moderna Inc.in the US on March 13.

Their approach allows for antibodies to be made in the human trial volunteers against a specific protein on the surface of the coronavirus that lets the virus enter human cells.

The hope is that the antibodies will stop the interaction.

Though this approach is designed to be effective against COVID-19 specifically, Lewis said Entos is taking a different tack.

The company plans to use plasmid DNA to amplify the production of key coronavirus surface and structural proteins with each injection, with an eye to the bigger picture.

"Many of the structural proteins in the virus are pretty well conserved across all the coronaviruses, including SARS and MERS," said Lewis.

"We're hoping that if we express more of the structural proteins that are common to most coronaviruses, we can inhibit the current COVID-19, and also potentially protect against all coronaviruses both past and future," Lewis added.

To move the project forward quickly, the company is seeking financial support from both provincial and federal levels of government.

"We have the opportunity to save a lot of lives, and I think it's really upon us and governments to find solutions for that," Lewis said.

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Agencies
July 24,2020

Chengdu, Jul 24: China on Friday asked the US to close down its Consulate in Chengdu in retaliation to Washington's decision to shut the Chinese Consulate in Houston.

A statement by the Chinese Foreign Ministry said China has informed the US Embassy of its decision to withdraw its consent for the establishment and operation of the US Consulate General in Chengdu.

This was in response to "unilateral" decision by the US to shut the Houston Consulate. China's decision is legitimate and necessary response to the unreasonable actions of the US, it said.

The US on Wednesday ordered the closure of the Chinese consulate in Houston, a move it said was aimed "to protect American intellectual property and private information."

Reacting strongly to the US move, Chinese Foreign Ministry spokesman Wang Wenbin termed it as an "unprecedented escalation and warned retaliatory measures.

China on Thursday said that "malicious slander" is behind an order by the US government to close its consulate in Houston, Texas, and maintained that its officials have never operated outside ordinary diplomatic norms.

Wang said the order to close the consulate violates international law and basic norms governing international relations, and seriously undermines China-US relations.

This is breaking down the bridge of friendship between the Chinese and American people, Wang said.

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News Network
June 15,2020

New Delhi, Jun 15: Two officials working with the Indian High Commission in Islamabad have reportedly gone missing, sources said.

The two officials are untraceable for the last few hours.

Recently news agency reported on how Pakistan 's spy agency ISI has been tailing and harassing Indian officials and also increased their presence at the residence of Acting High Commissioner Gaurav Ahluwalia.

This incident came in the backdrop when two Pakistani officials were caught red-handed and sent back trying to collect classified information and spying in Delhi.

South block is watching the developments closely, the Indian mission has also launched a complaint with local authorities and taken up the matter Pakistan Foreign Ministry.

This incident can cause a further dip in the already tense India-Pakistan relations.

Earlier in the month, India deported two Pakistani officials for espionage activities in India.

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