Protein that may prevent heart attack, stroke identified

Agencies
July 17, 2017

London, Jul 17: Scientists have identified a naturally occurring protein in the human body that protects against heart attacks and strokes, and may help develop new therapies to prevent the build up of fat in the arteries.heartattack

Researchers from King's College London in the UK measured the level of the dickkopf-related protein 3 (DKK3) in blood samples collected from 574 people over five years.

They found that those people with higher levels of DKK3 were less likely to develop atherosclerosis or to die from a heart attack or stroke.

This correlation was independent of other atherosclerosis risk factors such as high blood pressure and cholesterol levels, researchers said.

Atherosclerosis is the build-up of fatty material inside the arteries. When this material breaks down a blood clot can form blocking the blood supply to the heart or brain, causing a heart attack or stroke.

Researchers found that mice bred to be genetically deficient in the DKK3 protein also developed larger, less stable atherosclerotic plaques than those who could produce the protein.

They noted that DKK3 deficient mice were also less able to regrow the endothelial lining coating their blood vessels after it had been damaged.

This suggests that DKK3 is able to protect against atherosclerosis by helping the endothelial lining repair itself at the first sign of damage, before any fatty deposits can build up.

"Our work suggests that we could use a simple blood test to find seemingly healthy people who are at risk of heart attack, and would not routinely be identified as at risk by their general physician," said Qingbo Xu, professor at King's College London.

"Ultimately it may also be possible to boost DDK3 levels and protect people against the fatty build ups which can cause a heart attack or stroke," Xu added.

"By identifying a new protective molecule this research may lead to new medicines to further reduce the risk of a heart attack," said Jeremy Perarson, professor at British Heart Foundation.

Each year in the UK there are around 200,000 hospital visits due to heart attacks.

This research shows that it might be possible to treat the root cause of this devastating disease, ultimately saving lives.

The study was published in the journal Circulation.

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News Network
February 4,2020

Toronto, Feb 4: People who text while walking face a higher risk of an accident than those listening to music or talking on the phone, a study has found.

The study, published in the journal Injury Prevention, found that smartphone texting is linked to compromised pedestrian safety, with higher rates of 'near misses', and failure to look left and right before crossing a road.

Researchers from the University of Calgary in Canada call for a more thorough approach to exploring the impact of distracted pedestrian behaviours on crash risk.

Worldwide, around 270,000 pedestrians die every year, accounting for around a fifth of all road traffic deaths, according to the researchers.

'Pedestrian distraction' has become a recognised safety issue as more and more people use their smartphones or hand held devices while walking on the pavement and crossing roads, they said.

The researchers looked for published evidence to gauge the potential impact on road safety of hand-held or hands-free device activities.

This included talking on the phone, text messaging, browsing and listening to music.

From among 33 relevant studies, they pooled the data from 14 -- involving 872 people -- and systematically reviewed the data from another eight.

The analysis showed that listening to music wasn't associated with any heightened risk of potentially harmful pedestrian behaviours.

Talking on the phone was associated with a small increase in the time taken to start crossing the road, and slightly more missed opportunities to cross the road safely.

The researchers found that text messaging emerged as the potentially most harmful behaviour.

It was associated with significantly lower rates of looking left and right before or while crossing the road, and with moderately increased rates of collisions, and close calls with other pedestrians or vehicles, they said.

Texting also affected the time taken to cross a road, and missed opportunities to cross safely, but to a lesser extent, according to the researchers.

The review of the eight observational studies revealed that the percentage of pedestrians who were distracted ranged from 12 to 45 per cent, they said.

It also found behaviours were influenced by several factors, including gender, time of day, solo or group crossing, and walking speed.

The researchers acknowledge "a variety of study quality issues" which limit the generalisability of the findings.

"Given the ubiquity of smartphones, social media, apps, digital video and streaming music, which has infiltrated most aspects of daily life, distracted walking and street cross will be a road safety issue for the foreseeable future," the researchers noted.

"And as signage and public awareness campaigns don't seem to alter pedestrian behaviour, establishing the relationship between distracted walking behaviour and crash risk is an essential research need," they said.

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Agencies
June 23,2020

The record levels of new daily COVID-19 cases are due to the fact that the pandemic is peaking in a number of big countries at the same time and reflect a change in the virus' global activity, the World Health Organisation said.

At a media briefing on Monday, WHO's emergencies chief Dr Michael Ryan said that the numbers are increasing because the epidemic is developing in a number of populous countries at the same time.

Some countries have attributed their increased caseload to more testing, including India and the US But Ryan dismissed that explanation.

We do not believe this is a testing phenomenon, he said, noting that numerous countries have also noted marked increases in hospital admissions and deaths neither of which cannot be explained by increased testing.

There definitely is a shift in that the virus is now very well established, Ryan said. The epidemic is now peaking or moving towards a peak in a number of large countries.

He added the situation was definitely accelerating in a number of countries, including the US and others in South Asia, the Middle East and Africa.

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Agencies
April 14,2020

There is no evidence that the Bacille Calmette-Guerin (BCG) vaccine, which is primarily used against tuberculosis, protects people against infection with the novel coronavirus, the World Health Organization (WHO) said.

The WHO therefore didn't recommend BCG vaccination for the prevention of COVID-19 in the absence of evidence, according to its daily situation report on Monday, Xinhua news agency reported.

"There is experimental evidence from both animal and human studies that the BCG vaccine has non-specific effects on the immune system. These effects have not been well characterized and their clinical relevance remains unknown," WHO stated.

Two clinical trials addressing the question are underway, and WHO will evaluate the evidence when it is available, it noted.

BCG vaccination prevents severe forms of tuberculosis in children and diversion of local supplies may result in an increase of disease and deaths from the tuberculosis, it warned.

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