Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
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You people can check reports, SDPI people involved in many RSS workers' murder. They didnt get proper punishmnet
How BJP became communal..! BJP stands for patriotism. SDPI people working for conversion of people and making issues. That party should be banned fully.
Shame mr. rai. You only making the situation more complicated. By terming 'communal hub', you are injecting fear to common people.
BJP, SDPI both are communal they agreed. Should add more. BD, PFI etc
Dear Mr. Rai, with due respect, you and your party before flagging off the rally must answer the following questions to the general public!
1) you and your party won many times and even ruled undivided DK District but, why have you failed to controll the RSS and its hate campaign aginst a particular community???
2) During the last assemble election you have made public that once you got elected, you will send prabahkar bhat to jail! what action have you taken??
3) your own party worker late mr. Jaleel karopadi murdered by RSS Goons, what action and justice you have done to his father? who openly cried for justice and in anger he critisized you for failing to provide him justice!
4) under your constituency there were many muslim leaders and activists murder happend were were you that time?
5) the national tragedy of Babri masjid was demolished under congress rule and your national leadership maintained the soft hindutva, why have your party failed to protect it ..?
6) your national leadership had once said we will give justice to muslim community, and will rebuild babri masjid, being in a power for more than 10 years why your party couldnt provide the justice to the victims??? 7) your party have appointed the sri krishna commission! what action your party implimented against the hindutva brigade??
8) you and your party claims that, we are the protector of minority community! what protection you and your party provided for indian muslims?? since 70 years they have been looted, burnt alive, raped,tortured, made refugees, made scape-goat as terrors, etc etc ???
during all those time indian muslims dedicated their trust on all the so called secular partys, but all of them ditched to the community and maintained soft hindutva!
The anger, Disappointment, Frustration, and the Thawakkul on allah made to born SDPI on indian soil..!! that is the reality, that nobody cannot deny!!
Your Failure is SDPI's Stength, and SDPI's Success is indian oppressed community's success..!!
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