Rains lash parts of Karnataka, bring smiles and tears

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Mangalore, May 2: More than 500 families received ration kits in a distribution drive conducted by St Agnes College in outskirts of Mangaluru on Wednesday.

Since the lockdown was announced, the management, staff and alumni of St Agnes College are playing an active role in ensuring no one is deprived of food and essentials during these challenging pandemic times.

The College as part of its Agnes towards Community (ATC) programme had adopted villages such as Munnur, Harekala, Amlamogaru, Someshwara and Pavur. Various development drives are conducted in these villages by the staff and students. However, due to the COVID-19 lockdown, the activities undertaken in these villages were kept on hold.

The College recently received information from its network that several families in these villages are struggling for food and essentials.

The College management in association with its alumni and well-wishers took-up the initiative to distribute ration kits consisting of rice, dal, spices, tea powder, hygiene products and other essentials to 500 needy families belonging to these villages.

The drive was held in presence of Zilla Panchayat member Dhanalakshmi Gatty and other Gram Panchayat members.

"We were able to provide food to 600 and more families in different villages and to the stranded migrant workers in the city during this time of crisis because of the generous contributions of our staff, alumni and well wishes" says Sr Dr. M. Jeswina A.C.

The College management expresses its gratitude to all donors, especially the staff, alumni and those associated with the college.

Kozhikode, Jun 14: A mosque in Kuttichira of Kozhikode has found a unique way to avoid crowding amid the COVID-19 pandemic. The committee that runs the mosque has started issuing smart cards to people for offering prayers and simultaneously encouraging social distancing.

"The committee has given smart cards with numbers to the people in the surroundings of the Masjid. One who enters the mosque premises has to rub their hands with sanitizers. They also have to tell their identity on camera. The automatic system has been put in place to save the address and phone number. Next time onwards they have to say their smart card number only so that other details will be automatically filled," said Muhammad Sajjad, who is part of the Mosque committee.

"The door of the mosque will open automatically after swiping the card. We have fit in a sensor on the doors. We have also made marks inside the mosque area so that people can abide by social distancing norm," he added.

A couple of days back the Kerala government has rolled out an order allowing the opening of places of worship, malls and restaurants from June 9 in strict accordance with guidelines and social distancing norms. As per the guidelines, pregnant women and those with co-morbidities should not visit any places of worship. Those with symptoms should not be allowed.