Rambhapuri seers warns of waging religious war

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Mangaluru, Jul 10: The new team of office bearers of Mangalore Toastmasters Club for the year 2020-21 was installed in an online ceremony themed “Unlockdownable MTM” on 04th July, 2020. The new team will be led by Shraddha S Pai as President and her team consisting of Dr. Sapna Ramaraj as Vice President-Education, Ranjani Vittaldas as Vice President-Membership, Fiona Pinto as Vice President-Public Relations, Aashitha Shetty as Treasurer, Chandrashekar Palekar as Secretary and Oliver Lobo as Sergeant-at-arms. Dr. Ananth Prabhu, motivational speaker and cyber law investigator was the chief guest for the occasion.

In his speech, Dr. Ananth Prabhu emphasized the necessity for a paradigm shift towards cyber security with the rampant increase in digitization. He mentioned three out of fifteen skills that are absolutely necessary for anyone to be successful - how to impress people, independent living and surviving skills and how to bounce back when you fall. The remaining 15 can be found detailed in his book - The Samurai who sold his Suzuki which he presented to the outgoing and incoming Presidents.

Aashitha Shetty was the anchor for the program. Chandrashekar Palekar rendered the invocation and Benzita Ferrao welcomed the gathering. Outgoing President Kavitha Kamath thanked her entire team, mentors and the club members for their support during her tenure. Outgoing Vice President-Education Mareena Seema presented the Toastmaster of the year award to Distinguished Toastmaster M. N. Pai. Jyothi Hebbar presented an elaborate Secretary’s report highlighting the club’s happenings, events and achievements during the past year 2019-20.

Sunitha Periera introduced the 11 new members of the club who were then inducted by Division F Director Molly Chaudhuri. The Oath-taking of the new office bearers was presided over by Area F3 Director Sapna Shenoy. In her acceptance speech, Shraddha S Pai thanked the club members for putting their confidence in her and electing her to the new position. She spoke of her sense of debt and duty to those who held the office before her and promised to do her best in meeting the challenges in the coming year.

17 Representatives and leaders from different clubs of Division F including Club Growth Director Savitha Salian, Division Director Molly Chaudhuri and veteran toastmasters Malini Hebbar and Phyllis D’Costa felicitated the outgoing and incoming office bearers. Isha S Pai, daughter of newly sworn-in President Shraddha S Pai and Mrs. Vijaya Kudva, mother of outgoing President Kavitha Kamath also felicitated the new team. The vote of thanks was proposed by Princita Ferrao. Technical support was handled by Praveen M.N. and Yvonil D’Souza.

Mangalore Toastmasters club is built on 17 glorious years of support and encouragement of a healthy mix of veteran as well as rookie toastmasters. Bagging 93 educational awards, the club has placed 11th worldwide in the past year, upholding Toastmasters International’s core values of integrity, dedication to excellence, service to the member and respect for the individual.

Bengaluru, Jan 24: Karnataka High Court on Friday ordered notice to the state government and self-styled godman Swami Nithyananda while hearing a petition seeking cancellation of bail granted to him.

A petition was filed in the Karnataka High Court on Friday seeking cancellation of bail granted to Nithyananda for skipping the trial and fleeing the country.

Justice John Michael Cunha, after hearing the complainant, ordered issuance of notice to the state government and Nithyananda and posted the matter for hearing next week.

The petition, filed by K Lenin, alleged that Nithyananda has been skipping trial and has fled the country on an expired passport.

The plea further said that Nithyananda was making false representations in his "exemption petitions to the trial court as if he is still in India".

Interpol has also issued a 'blue corner notice' to locate the self-styled godman, who is facing trial in a criminal case, on the request of Gujarat Police.