Regulate eating, sleeping time to boost metabolism

Agencies
November 9, 2018

Washington D.C, Nov 9: Did you know! Your eating and sleeping pattern regulates the amount of calories you burn.

Researchers found that when at rest, people burn 10 percent more calories in the late afternoon and early evening than in the early morning hours.

The findings have been published in the journal Current Biology.

They reinforce the important role of the circadian clock in governing metabolism. They also help to explain why irregularities in eating and sleeping schedules due to shift work or other factors may make people more likely to gain weight.

“The fact that doing the same thing at one time of day burned so many more calories than doing the same thing at a different time of day surprised us,” said lead author Kirsi-Marja Zitting of Harvard Medical School.

To determine changes over the course of the day in metabolism apart from the effects of activity, sleep-wake cycle, and diet, the researchers studied seven people in a special laboratory without any clues about what time it was outside. There were no clocks, windows, phones, or Internet. Study participants had assigned times to go to bed and wake up. Each night, those times were adjusted four hours later, the equivalent of traveling westward across four time zones each day for three weeks.

“Because they were doing the equivalent of circling the globe every week, their body’s internal clock could not keep up, and so it oscillated at its own pace,” co-author Jeanne Duffy explained. “This allowed us to measure metabolic rate at all different biological times of day.”

The researchers found that participants’ respiratory quotient, which reflects macronutrient utilisation, varies by circadian phase, too. This measure was lowest in the evening and highest in the biological morning.

The findings offer the first characterisation of a circadian profile in fasted resting energy expenditure and fasted respiratory quotient, decoupled from effects of activity, sleep-wake cycle, and diet in humans, the researchers said.

“It is not only what we eat, but when we eat–and rest–that impacts how much energy we burn or store as fat,” Duffy said. “Regularity of habits such as eating and sleeping is very important to overall health.”

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Agencies
May 2,2020

Clinician-scientists have found that Irish patients admitted to hospital with severe coronavirus (COVID-19) infection are experiencing abnormal blood clotting that contributes to death in some patients.

The research team from the Royal College of Surgeons in Ireland found that abnormal blood clotting occurs in Irish patients with severe COVID-19 infection, causing micro-clots within the lungs.

According to the study, they also found that Irish patients with higher levels of blood clotting activity had a significantly worse prognosis and were more likely to require ICU admission.

"Our novel findings demonstrate that COVID-19 is associated with a unique type of blood clotting disorder that is primarily focussed within the lungs and which undoubtedly contributes to the high levels of mortality being seen in patients with COVID-19," said Professor James O'Donnell from St James's Hospital in Ireland.

In addition to pneumonia affecting the small air sacs within the lungs, the research team has also hundreds of small blood clots throughout the lungs.

This scenario is not seen with other types of lung infection and explains why blood oxygen levels fall dramatically in severe COVID-19 infection, the study, published in the British Journal of Haematology said.

"Understanding how these micro-clots are being formed within the lung is critical so that we can develop more effective treatments for our patients, particularly those in high-risk groups," O'Donnell said.

"Further studies will be required to investigate whether different blood-thinning treatments may have a role in selected high-risk patients in order to reduce the risk of clot formation," Professor O'Donnell added.

According to the study, emerging evidence also shows that the abnormal blood-clotting problem in COVID-19 results in a significantly increased risk of heart attacks and strokes.

As of Friday morning, the cases increased to 20,612 cases in Ireland, with 1,232 deaths so far, according to the Johns Hopkins University.

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Agencies
July 2,2020

London, Jul 2: The World Health Organisation says smoking is linked to a higher risk of severe illness and death from the coronavirus in hospitalised patients, although it was unable to specify exactly how much greater those risks might be.

In a scientific brief published this week, the U.N. health agency reviewed 34 published studies on the association between smoking and Covid-19, including the probability of infection, hospitalisation, severity of disease and death.

WHO noted that smokers represent up to 18% of hospitalised coronavirus patients and that there appeared to be a significant link between whether or not patients smoked and the severity of disease they suffered, the type of hospital interventions required and patients' risk of dying.

In April, French researchers released a small study suggesting smokers were at less risk of catching Covid-19 and planned to test nicotine patches on patients and health workers — but their findings were questioned by many scientists at the time who cited the lack of definitive data.

WHO says "the available evidence suggests that smoking is associated with increased severity of disease and death in hospitalized Covid-19 patients. It recommends that smokers quit.

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