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Chennai, Aug 5: Karnataka on Wednesday crossed the 1.5 lakh mark in respect of COVID-19 cases and Kerala was on the verge of 30,000 while Andhra Pradesh witnessed a five- digit daily caseload after a lull. 

Tamil Nadu saw a small jump in its daily cases as compared to Tuesday while Telangana and union territory Puducherry reported their respective record single-day spikes. 

The five states and the union territory reported a combined 24,415 fresh confirmed coronavirus cases and 316 fatalities on Wednesday. 

A Puducherry Minister tested positive for the deadly virus while an opposition AINRC legislator who contracted the coronavirus earlier was discharged after being cured of it. 

In Karnataka, the coronavirus cases stood at 1,51,449 with the addition of 5,619 fresh cases while 100 deaths were reported, pushing the total fatalities to 2,804, the health department said.

According to a health bulletin, 74,679 persons have been discharged so far, leaving 73,958 active cases. Andhra Pradesh''s COVID-19 surge continued on Wednesday too, with 10,128 cases reported afresh after easing a little in the last four days. 

The overall tally rose to 1,86,461 on Wednesday. The state had last reported its five-figure daily tally on July 31 when it was 10,376. 

The state also saw a record number of 77 coronavirus deaths in a day, pushing the toll to 1,681, the latest bulletin said. 

In the last 24 hours, 8,729 patients had also recovered from the infection and there were 80,426 active cases. 

As many as 1,04,354 patients have been cured and discharged so far. Kerala was on the verge of 30,000 cases, as its tally stood at 29,145 with the addition of 1,195 new COVID-19 cases on Wednesday.

The toll from the virus so far climbed to 94 with seven more deaths. Thiruvananthapuram continued to top the districts in infections with 274 cases on Wednesday, of whom 248 had been infected through contact. 

Malappuram (167), Kasaragod (128), Ernakulam (120) and Alappuzha (108) reported over 100 cases. As many as 112 patients died of COVID-19 in Tamil Nadu, the highest reported in a single day so far, taking the toll to 4,461 on Wednesday while 5,175 more people tested positive, propelling the case count to 2.73 lakh.

Recoveries outnumbered fresh cases with 6,031 people getting discharged from various hospitals, taking the total cured to 2,14,815 as the active cases dropped to 54,184, a government bulletin said. 

In Telangana, 2,012 new cases emerged while 13 related fatalities were reported, taking the total infection tally in the state to 70,958. Out of the new cases, 532 were from the Greater Hyderabad Municipal Corporation (GHMC), followed by Medchal-Malkajgiri 198 and Rangareddy 188, a state government bulletin said on Wednesday, providing data as of 8 PM on August 4. 

The total number of people who recovered from the infectious disease touched 50,814, while 19,568 were under treatment.

The COVID-19 fatality rate in the state was 0.81 per cent, while it was 2.10 per cent at the national level, it said. The recovery rate was 71.6 per cent in the state, while it was 66.31 per cent in the country, it added. 

Puducherry clocked its worst single-day spike of 286 infections, recording seven deaths, even as the overall tally of cases went up to 4,432. 

The deaths during the 24 hours in the Union Territory took the toll to 65 so far since the outbreak of the virus, Health Minister Malladi Krishna Rao told a virtual press conference. 

His cabinet colleague M Kandasamy and his son reported positive for the virus and were admitted to JIPMER.

Bengaluru, Aug 2: Bengaluru based Centre for Advanced Research and Development (CARD), the research wing of organisation De scalene has come up with a device called "SHYCOCAN" (Scalene Hypercharge Corona Canon) which neutralizes the coronavirus.

Speaking to news agency Dr Rajah Vijay Kumar, Chairman, Organisation De Scalene said that the device will not kill any bacteria or fungus, however, neutralizes the coronavirus particles.

"The device was tested for its safety and efficacy and is soon going to be manufactured and marketed in the US under the Enforcement Discretion policy of USFDA and in Europe as the device is CE compliant and is CE marked," said Kumar.

He also added the device will cover a volume of 10,000 cubic feet.

The device Scalene Hypercharge Corona Canon (SHYCOCAN) is intended to be used in the residential, industrial and commercial environment and is designed for active containment by attenuation of Corona family of viruses. (Laboratories de Especialidades Immunological S.A. de C.V, Virucidal Activity concludes 99.9 per cent virus elimination), Kumar asserted.

"SHYCOCAN operates on regular 110/240V - 50/60 Hz wall socket and is a plug and play device, that delivers the necessary signals to a photon mediated electrons emitters (PMEE), that produces hypercharge high-velocity electrons by photon mediation that interacts with the negative seeking S-protein of Corona family of viruses thus reducing infectivity and prevent air and surface borne transmission of corona family of viruses," said Kumar.

The device does not use any chemicals, or any other consumables and does not produce harmful ozone gas or any other substances and is completely safe for use in any environment, he added.

"The attack mechanism of the Virus starts with the initial attachment of the virion to the host cell, it is initiated by interactions between the S-protein and its receptor on the "negative" cell membrane. The sites of receptor binding domains (RBD) within the S1 region of a coronavirus S-protein vary depending on the virus. 

The S-protein/receptor interaction is the primary determinant for a coronavirus to infect a host species and governs the tissue tropism of the virus. However, the end result is the fusion and release of the viral genome into the cytoplasm," said Kumar.

He continued saying that the counter mechanism by the device SHYCOCAN is that if negative seeking is the guidance mechanism of the S- Protein, attracted by the transmembrane potential of the host cells, then breaking this mechanism would block the Coronavirus infectivity and spread.

"The device has been in use for more than a year at the S-CARD campus, the headquarters of Scalene," said Kumar.