Scientists find compound to fight virus behind MERS and SARS

June 1, 2014

Geneva, Jun 1: An international team of scientists say they have identified a compound that can fight coronaviruses, responsible for the SARS and MERS outbreaks, which currently have no cure.

MERS and SARSCoronaviruses affected the upper and lower respiratory tracts in humans.

They are the reason for up to a third of common colds.

A more severe strain of the virus, thought to have come from bats, triggered the global SARS (Severe Acute Respiratory Syndrome) epidemic in 2002 that killed nearly 800 people.

The Middle East Respiratory Syndrome (MERS) is a new strain discovered in Saudi Arabia in 2012 and thought to have originated in camels. More deadly but less contageous, it has so far killed 193 people across 636 confirmed cases.

But now a team of scientists led by Edward Trybala from the University of Gothenburg in Sweden, and Volker Thiel from the University of Bern have discovered a compound called K22, which appears to block the ability of the virus to spread in humans.

They first noticed that K22 was able to combat a weak form of coronavirus that causes mild cold-like symptoms, and went on to show that it can fight more serious strains, including SARS and MERS.

In an article for specialist journal "PLOS Pathogens", the scientists explained that the virus reproduces in the cells that line the human respiratory system.

The virus takes over the membranes that separate different parts of human cells, reshaping them into a sort of armour around itself in order to start its production cycle.

But K22 acts at an early stage in this process, preventing the virus from taking control of the cell membranes.

"The results confirm that the use of the membrane of the host cell is a crucial step in the life-cycle of the virus," the researchers wrote.

Their work shows that "the process is highly sensitive and can be influenced by anti-viral medications."

They said the recent SARS epidemic and MERS outbreak mean there should be urgent investment in testing K22 outside the laboratory and developing medicines.

Earlier this month, experts gathered in Geneva by the World Health Organisation confirmed that MERS was spreading but had yet to reach the level of global emergency.

Most of the MERS cases and deaths so far have been in Saudi Arabia, but the virus has been imported to more than a dozen other countries.

All of those cases have involved people who became ill while in the Middle East.

Iran registered its first death from MERS on Thursday, and has registered six cases of the infection.

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Agencies
June 18,2020

New Delhi, Jun 18: Reliance Industries Ltd on Thursday said it has sold a 2.32 per cent stake in its digital unit to Saudi Arabia's Public Investment Fund (PIF) for Rs 11,367 crore, taking the cumulative fund raising to about Rs 1.16 lakh crore in two months.

Starting with Facebook Inc on April 22, Reliance has sold almost 25 per cent of equity in Jio Platforms - the maximum reports suggest the company intends to dilute to financial investors.

The investment by Saudi sovereign wealth fund is "at an equity value of Rs 4.91 lakh crore and an enterprise value of Rs 5.16 lakh crore", the company said in a statement.

With this investment, Jio Platforms has raised Rs 115,693.95 crore from some of the leading global investment powerhouses at a time when the world is deeply impacted by the coronavirus pandemic, resulting in a recession kind of environment for the global economy.

"With the addition of PIF's investment, Jio Platforms has established partnerships with a marquee set of global financial investors, who will contribute to establishing the Digital Society vision for India," the statement said.

Jio Platforms houses India's biggest telecom firm by subscribers, Reliance Jio. With more than 388 million users, Jio has forced out several rivals and driven consolidation in the sector since entering the market in 2016 with free voice services and cut-price data.

Over the past two months, billionaire Mukesh Ambani's oil-to-telecom conglomerate has announced the sale of about $14 billion of assets, completed a Rs 53,124 crore rights issue and slowed the run rate of new investment by a quarter.

These will help Reliance meet its target of paying off Rs 1.61 lakh crore of net debt by the end of the year.
This is PIF's largest investment into the Indian economy to date.

Ambani, chairman and managing director of Reliance Industries, said, "We at Reliance have enjoyed a long and fruitful relationship with the Kingdom of Saudi Arabia for many decades. From oil economy, this relationship is now moving to strengthen India's New oil (data-driven) economy, as is evident from PIF's investment into Jio Platforms."

Yasir Al-Rumayyan, governor of PIF, commented: "We are delighted to be investing in an innovative business which is at the forefront of the transformation of the technology sector in India. We believe that the potential of the Indian digital economy is very exciting and that Jio Platforms provides us with an excellent opportunity to gain access to that growth."

"This investment will also enable us to generate significant long-term commercial returns for the benefit of Saudi Arabia's economy and our country's citizens, in line with our mandate to safeguard and grow the national wealth of the Kingdom," he said.

The transaction is subject to Indian regulatory and other customary approvals.

Morgan Stanley acted as financial advisor to Reliance Industries and AZB & Partners and Davis Polk & Wardwell acted as legal counsels.

Prior to this deal, Reliance had sold 22.38 per cent of Jio Platforms to investors including Facebook Inc, securing Rs 104,326.95 crore in eight weeks.

Facebook kicked off the party, investing Rs 43,573.62 crore for a 9.99 per cent stake on April 22. This was closely followed by a further Rs 60,753.33 crore in investment.

Silver Lake - the world's largest tech investor - bought a 1.15 per cent stake in Jio Platforms for Rs 5,665.75 crore on May 4. It invested another Rs 4,546.80 crore for additional 0.93 per cent stake on June 5, taking its total holding to 2.08 per cent
Private equity KKR and Vista Equity Partners have taken 2.32 per cent stake each for Rs 11,367 crore apiece. KKR invested in Jio Platforms on May 22 while Vista invested on May 8.

Abu Dhabi sovereign wealth fund Mubadala Investment Co picked up 1.85 per cent in Jio Platforms for Rs 9,093.60 crore on June 5. Abu Dhabi Investment Authority on June 7 invested Rs 5,683.50 crore for a 1.16 per cent stake in Jio Platforms.

On May 17, global equity firm General Atlantic picked up 1.34 per cent stake in Jio Platforms for Rs 6,598.38 crore.

Global investment firm TPG on June 13 picked up 0.93 per cent for Rs 4,546.80 crore while L Catterton bought 0.39 per cent for Rs 1,894.50 crore.

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News Network
May 3,2020

Jeddah, May 3: Saudis and expats who spread rumors on social media could be jailed for up to five years and fined SR3 million ($800,000) under measures to counter false information regarding the coronavirus pandemic.

The move follows warnings by Saudi Arabia’s Ministry of Health, Ministry of Interior, General Presidency of the Two Holy Mosques and other government entities that people should rely on trusted news sources and not third parties for information on the Kingdom’s handling of the COVID-19 outbreak.

The Saudi Public Prosecutor warned that legal action will be taken against individuals who spread misinformation and rumors.

On Saturday, media spokesman for the Riyadh region police, Col. Shakir Al-Tuwaijri, highlighted a video circulating on social media in which a person spreads rumors about steps taken to curb the spread of the coronavirus.

Other false claims include a planned change in curfew hours, warnings of food shortages, and a suggestion that health authorities are deliberately concealing the number of cases in the Kingdom.

In a recent case, a Riyadh resident claimed to know when worshippers will be allowed to return to the Grand Mosque.

All suspects have been arrested and face legal action, police said.

Dimah Al-Sharif, a Saudi legal counsel and member of the International Association of Lawyers, urged people to be responsible regarding content they access on social media.

“Receivers should not save such content or share it with others, and should delete it if possible since they, too, will be liable,” she said.

“Under Saudi laws to counter cyber-crime, we are not allowed to produce, prepare, send or save any unauthorized content or rumors.”

Individuals who breach regulations can be jailed for up to five years and face fines of SR3 million, as well as confiscation of the device(s) used in the crime, she said.

In addition, the judicial ruling will be published in newspapers at the offender’s expense.

The Kingdom’s Public Prosecution Office took to social media to warn users about the consequences of spreading rumors and misinformation.

@bip_ksa tweeted: “Receiving information from its official sources is a moral obligation and commitment, and legal responsibility. Do not fall victim to malicious rumors and news from anonymous sources that violate the procedures and effort, and cause terror regarding the Coronavirus, in order to avoid strict criminal accountability in this regard.”

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News Network
January 16,2020

Abu Dhabi, Jan 16: The number of people being killed by terrorism activities worldwide has decreased significantly over the recent years, according to the latest Global Terrorism Index.

The 2019 Global Terrorism Index, which was presented at a forum in Abu Dhabi on Wednesday also showed that the UAE improved its ranking in the index by coming down to 130th rank among the 163 countries. The terrorism impact in the UAE is categorised as 'very low'. In the UAE, only two terrorism incidents were reported over the past decade - one in 2010 and another in 2014 - and there were no casualties.

Commenting on the report, Mansour Al Mansouri, director of the UAE National Media Council (NMC) said: "These findings rightly show the UAE as one of the safest countries in the world in terms of terror threat."

The index showed that the total number of deaths from terrorism declined for the fourth consecutive year in 2018, falling by 15.2 per cent to 15,952 deaths. This represents a 53 per cent reduction since its peak in 2014 when 33,555 people were killed in terrorist attacks.

The index published for the seventh year in a row, ranks 163 countries across the globe according to the relative impact of terrorism. This takes into account the number of terrorist incidents, deaths caused by terror and total value of property damage.

The latest results saw three Middle East countries - Iraq, Syria and Yemen - continue in the top 10 positions of the index.

The findings also showed Taleban overtaking Daesh as the deadliest terrorist group in the world, accounting for 38 per cent of all terrorist deaths. This is an increase of 71 per cent. Afghanistan is the country most affected by terrorism in 2018 followed by Iraq, Nigeria, Syria and Pakistan, according to the report. The least impacted nations were Belarus, Guinea-Bissau, Oman, The Gambia and North Korea.

During his presentation of the key findings of the index at the Foreign Correspondent's Club of the UAE (FCC), Serge Stroobants, director of Europe and Mena at the Institute of Economics and Peace, said lesser people were now being killed in terrorism activities.

"There have been long-term trends in global terrorism, with deaths caused by terror down by 52 per cent compared to high point of 2014, which saw Daesh and Boko Haram at their peak," said Stroobants attributing the decrease in the deaths to the increase in security measures and cooperation among nations in the fight against terrorism.

In contrast to this, there has been a 320 per cent increase in far-right terrorist incidents in the West, with political ideology being the driving force behind an increased proportion of terror motivation.

"There has been an increase in far-right terrorism in Western Europe, North America and Oceania for the third consecutive year," said Stroobants.

Terrorism still remains a global security threat, according the index, with 71 countries recording more than one death - the second highest number of countries since 2002.

Stroobants said conflicts remain the main cause of terrorism with 90 per cent of terrorist incidents occurring in places where there are conflicts or insurgencies.

The report said the global economic impact of terrorism was $33 billion in 2018, a substantial decrease of 38 per cent from the previous year.

Boko Haram was responsible for 80 per cent of all female suicide attacks, said the terrorism index.

Global Terrorism Index: Most affected countries

>Afghanistan (7379 deaths)

>Iraq (1,054 deaths)

>Nigeria (2,040 deaths)

>Syria (662 deaths)

>Pakistan (537 deaths)

>Somalia (646 deaths)

>India (350 deaths)

>Yemen (301 deaths)

>The Philippines (297 deaths)

>Democratic Republic of the Congo (410 deaths)

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