Sihi Mutthu Bhagya: Siddaramaiah gets a surprise kiss from female fan in public

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Kasaragod, Apr 30: The Kasaragod District Collector Sajith Babu, his gun man and driver has entered in quarantine on Wednesday.

According to sources, the Collector had been asked to go on quarantine after the reports of a journalist, who interviewed him, was tested positive for the virus.

Chief Minister Pinarayi Vijayan at his routine evening press conference revealed the positivity of the journalist.

Bengaluru, Mar 13: This year, schoolchildren will have a longer summer vacation starting early, thanks to the new coronavirus onslaught. Primary and Secondary Education Minister Suresh Kumar on Thursday announced that schools in Bengaluru Urban and Rural districts will be closed for vacation from Friday.

Classes from LKG to sixth standard will closed for vacations till the schools reopen in June, while students of classes 7-9 will have ‘study holidays’ until their examinations commence (as scheduled by their respective schools). Their summer vacations will begin with the completion of their examinations.

Class 10 students will have their examinations according to the dates scheduled earlier.

“Let us not treat this as a panic reaction or something to cause a scare. This measure is taken as a precaution. A lot of parents were worried about their children. We have already announced the closure of schools from nursery to sixth standards. Now, we are declaring official holidays upto sixth standard. Students of standards 1-6 will all be promoted based on their formative assessment,” said Kumar adding, “no student will be detained in those classes.”

With respect to seventh, eighth and ninth standards, the schools will be closed for study holidays and students will have to return to write their examinations.“We will not interfere in the examination schedules of CBSE and ICSC schools. However, state syllabus schools have to finish their examinations before March 23”, Public Instruction Commissioner KG Jagadeesh said.Just a couple of papers of the PU examinations are left after which their holidays will begin.

Exam timetable not changed

Miscreants are spreading rumours that SSLC examination dates are changed because of the new coronavirus outbreak. However, Karnataka Secondary Education Examination Board director V Sumangala categorically said the examinations will be held from March 27  to April 9 as scheduled earlier.