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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Apr 14: Karnataka Chief Minister BS Yediyurappa on Tuesday welcomed Prime Minister Narendra Modi's decision to extend COVID-19 lockdown till May 3.

"Our government will strictly implement the Government of India guidelines, which will be issued tomorrow. Lockdown will be followed more stringently till April 20 as Prime Minister said and the situation will be closely monitored. I appeal to the people of Karnataka to voluntarily cooperate with us to contain this disease," Yediyurappa said.

The chief minister urged the people to respect seven major points that Prime Minister Modi raised in his televised address to the nation on Tuesday, while announcing the extension of coronavirus-induced lockdown.

"I appeal to people to follow the seven measures Prime Minister advised to follow, such as taking care of elders in the house especially those suffering from chronicle illness; strictly maintaining social distancing; enhancing immunity by following guidelines of Ayush Department; download Arogyasetu app; help the poor and needy; to be considerate about your colleagues and employees and not to sack them; and respect the police, healthcare professionals," Yediyurappa added.

The chief minister also assured that there is no scarcity of medicines, essential services and goods.

"We will make all efforts to carry out agriculture activities without any hurdle. I make a special appeal to migrant labours to stay wherever they are and be safe... Stay home and be safe," he said.

According to the Union Ministry of Health and Family Welfare, there are 247 COVID-19 positive cases in Karnataka including 59 cured, discharged, migrated and six deaths.

Bengaluru, Jan 23: Karnataka government on Thursday notified the much-hyped anti-superstition law that aims to prevent and eradicate "inhuman evil practices".

According to Social Welfare principal Secretary G Kumar Naik, the state social welfare department has issued a gazette notification and The Karnataka Prevention and Eradication of Inhuman Evil Practices and Black Magic Act, 2017, that intends to protect the common people against "evil" and "sinister" practices, shall come into force with effect from January 4 2020, the government notification issued earlier this month read.

The act seeks to combat and eradicate such inhuman practices propagated and performed in the name of "black magic" by conmen with the sinister motive of exploiting the common people, thereby destroying the social fabric of the society.