Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
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Vinaasha kalakke vipareetha budhi
I dont understand, why media giving attention to this rubbish speech.. He just wanted media attention. and also he wanted to thrill his followers..
Nalin Kumar Kateel is no. 1 terrorist. Once he told, he wanted to burn entire Mangalore.
Shakha trained bhakt ! Modi & Shah are very happy on his comment on CM. Nalin Don't worry you are eligible represent educated Mangalorean (?) in forth coming Parliament election -2019.
This kateel is delivering an election speech or mocking himself?
An uneducated goon who threatened to set entire Dakshina Kannada district on fire is a desh bhakt. And a farmers’ leader turned politician who upheld the concept of Kalnaya Rajya is a terrorist. What a joke.
Katilanna.. First learn language. The meaning of Sultan is King. You are hailing him as king. King will be terrorists for only terrorists.
I think politics of this region is a curse. There is no boundries to the wild allegation and lies that these politicians utter. I think we have to play back some of his terrorism speeches including burning of DK speech.
The only way we can stop BJP getting back to power in Karnataka is to switch to ballot system.
What they think they can fool all Kannadigas, as they did in North East, UP.
Unfortunately the people in that regions are very innocent. They don’t understand how they are being fooled by their leaders specially Modi and Amit Shah.
Now their own people are fed up of them. Many secular leaders left the BJP and jointed Congress.
Kateel is very lucky to be a MP who really does not deserve to be Grama Panchayat member.
The cleanest CM is Siddaramiah, in the recent generation, like very few CM s we had in the past like Nijalingappa, Kadidal Manjappa. He never indulged in single bribery or corruption.
He is Very straight and strong leader, who has always worry for the people. But our stupid opposition want to destroy him for their selfishness at the cost suffering of poor people.
May God almighty help our people to understand the fact and elect the best leaders.
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