Tamarind seed protein has potential to cure Chikungunya: IIT-R study

Agencies
November 14, 2018

New Delhi, Nov 14: Two professors at Indian Institute of Technology (IIT) Roorkee claimed to have discovered a protein in tamarind seeds that has anti-viral properties and can potentially be used to develop medication for chikungunya.

The research group at IIT Roorkee has filed a patent for an antiviral composition containing this tamarind antiviral protein and is now developing tamarind-based therapeutic agents for chikungunya.

"Tamarind is known for various medicinal properties in India and is a excellent Ayurvedic food. The fruits, seeds, leaves and roots bark of the tamarind tree have been used to treat abdominal pain, diarrhoea and dysentery, bacterial infections and parasitic infestations, wounds, constipation and inflammation," said one of the professors, Shaily Tomar.

Lectin, a diverse group of proteins derived from plant sources, are known to bind to glycan sugars. Its use as antiviral has been extensively studied for a range of viruses, including HIV and HPV.

The IIT professors, in a study, have shown that a lectin derived from tamarind seeds bind to glycans or sugar molecules having N-acetylglucosamine (NAG) on the capsule of viruses, thereby preventing the entry of the virus into the host cells.

The researchers have isolated lectin from tamarind seeds using chromatography and have studied the binding of the lectin molecules to the glycan in the viral capsule by a process called Enzyme-Linked ImmunoSorbent Assay (ELISA).

"Not only did the chikungunya virus lose 64 per cent of its infectivity on treatment with the lectin, but the levels of viral RNA in the cells were also found to reduce to nearly 45 per cent. This study has, for the first time, evaluated the antiviral use of tamarind seed-derived lectin having specificity for NAG and assessed its ability to block the entry step of the virus," Tomar added.

"Antiviral drugs and vaccines against most alphaviruses, including chikungunya are still not available in the market, and preventive measures are currently the only route to managing diseases caused by such viruses," said professor Pravindra Kumar, who is also part of the research.

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News Network
February 25,2020

Bengaluru, Feb 25: A smooth-talking ‘swamiji’ has come under police radar after a widow lodged a complaint stating he cheated her of over Rs 27 crore and three kgs of gold between 2016 and 2019.

The woman, Geetha of Ramamurthynagar, was staying with her three sons after her husband, a landlord, died in 2009. Her family owned several sites in Tavarekere and other parts of the city, apart from a farm near Bethamangala in Kolar district.

Geetha, who had got into property disputes with her relatives, said she was introduced to the accused, Nagaraj C of Bangarapet, who claimed to possess powers to ward off evil spirits, by one of her farm labourers. “I was assured that all my problems would be solved. He came to my house and claimed he had been sent by god and would find solutions to all my problems,” she stated.

Nagaraj allegedly pretended to be possessed by spirits and directed her to give him gold bars. Geetha ended up giving three kgs of gold in the process. Later, he began directing her to sell a few properties stating these were the root cause of her problems. “I sold many properties and pledged a few residential sites. He took Rs 22.5 crore that came from selling properties, apart from Rs 5 crore cash from my husband’s savings,” she stated.

She said Nagaraj took the money from her on the promise of buying alternative properties. “When I demanded he return all my money, he threatened to kill me and my kids using evil spirits,” she alleged.

Police have registered a case of cheating, criminal conspiracy, criminal intimidation under various IPC sections and Karnataka Prevention and Eradication of Inhuman Evil Practices and Black Magic Bill, 2017, against Nagaraj and others.

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News Network
January 31,2020

Mangaluru, Jan 31: Mahesh Vikram Hegde, the co-founder of website 'Postcard News', known for spreading fake news on behalf of Sangh Parivar, was taken aback when he was asked to sing 'Vande Mataram' to prove his patriotism by a group of women activists at Mangaluru International Airport.

The video of the incident which occurred on Friday, days after editor-in-chief and co-founder of Republic TV Arnab Goswami was heckled by comedian Kunal Kamra on a flight, went viral on social media within hours.

Hegde was spotted by social activist Kavitha Reddy, and other young orators – Najma Nazeer and Amulya Leona – at the airport where he was waiting to board a plane to Bengaluru.

In a video, the three women are seen coercing Hegde to sing 'Vande Mataram' and prove his patriotism. In another video being circulated, the women are heard telling the journalist that he is getting an opportunity to become a 'hero' from 'zero' if he sings 'Vande Mataram.' However, he refused to open his mouth.

Reddy is seen asking Hegde whether he knew the time when Nathuram Godse assassinated Mahatma Gandhi.

Hegde was arrested in 2018 for posting a fake news aimed at creating communal conflict.

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Agencies
April 15,2020

Dear parents, if you want your children to have proper sleep, read this carefully. Joining a growing list of studies that tell parents to shun devices at bed-time, researchers say that children who use devices and decide what time they go to sleep, achieve less sleep and feel more sleepier the following day than their peers.

The study of children in this age-group (aged 11 to 13 years), published in the New Zealand Medical Journal, found most (72 per cent) of the 163 students interviewed by University of Otago researchers achieved recommended guidelines of an average 9 to 11 hours sleep nightly over one week.

"But that also means that almost one in four students did not achieve sleep within these guidelines, which highlights an area for improvement," said study researcher Kate Ford.

However, consistent with previous research in 15 to 17-year-old New Zealanders, the study results show less sleep on the nights where devices are used in the hour before bed.

According to the researchers, students who used devices before going to sleep were also more likely to report that they felt sleepy the following morning. Watching television before bed had no significant effect on sleep length.

There were also some interesting observations over the weekends where students went to bed later but woke later achieving similar sleep length to the school days, the researchers said.

A small group of students (six per cent) who reported less than seven hours of sleep, including a small number reporting not sleeping at all, according to the study,

Therefore, while the average across the week of 72 per cent of students reporting adequate sleep is reassuring, it is far from the goal of every child achieving sleep within the recommended guidelines," Ford said.

Dr Paul Kelly, head of the Sleep Health Service at Canterbury District Health Board, supervised the study and explained that the foundations for good health are based on proper nutrition, regular exercise and good sleep quality.

Sleep quality is often overlooked as a contributory factor to poor health.

"The study findings suggest the need for parental guidance around bedtimings and moderation of the use and availability of electronic devices before bed," Kelly said.

"Respect and protect your sleep, as good daytime functioning is reliant on adequate sleep," Kelly added.

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