Tamarind seed protein has potential to cure Chikungunya: IIT-R study

Agencies
November 14, 2018

New Delhi, Nov 14: Two professors at Indian Institute of Technology (IIT) Roorkee claimed to have discovered a protein in tamarind seeds that has anti-viral properties and can potentially be used to develop medication for chikungunya.

The research group at IIT Roorkee has filed a patent for an antiviral composition containing this tamarind antiviral protein and is now developing tamarind-based therapeutic agents for chikungunya.

"Tamarind is known for various medicinal properties in India and is a excellent Ayurvedic food. The fruits, seeds, leaves and roots bark of the tamarind tree have been used to treat abdominal pain, diarrhoea and dysentery, bacterial infections and parasitic infestations, wounds, constipation and inflammation," said one of the professors, Shaily Tomar.

Lectin, a diverse group of proteins derived from plant sources, are known to bind to glycan sugars. Its use as antiviral has been extensively studied for a range of viruses, including HIV and HPV.

The IIT professors, in a study, have shown that a lectin derived from tamarind seeds bind to glycans or sugar molecules having N-acetylglucosamine (NAG) on the capsule of viruses, thereby preventing the entry of the virus into the host cells.

The researchers have isolated lectin from tamarind seeds using chromatography and have studied the binding of the lectin molecules to the glycan in the viral capsule by a process called Enzyme-Linked ImmunoSorbent Assay (ELISA).

"Not only did the chikungunya virus lose 64 per cent of its infectivity on treatment with the lectin, but the levels of viral RNA in the cells were also found to reduce to nearly 45 per cent. This study has, for the first time, evaluated the antiviral use of tamarind seed-derived lectin having specificity for NAG and assessed its ability to block the entry step of the virus," Tomar added.

"Antiviral drugs and vaccines against most alphaviruses, including chikungunya are still not available in the market, and preventive measures are currently the only route to managing diseases caused by such viruses," said professor Pravindra Kumar, who is also part of the research.

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coastaldigest.com news network
February 3,2020

Dammam, Feb 3: Harish Bangera, 32, who was arrested in Kingdom of Saudi Arabia more than a month ago after offensive Facebook post went viral, has remained incommunicado.

Bangera, who hails from Goyadibettu in Bijadi village of Kundapur taluk, Udupi district, was an air-conditioning technician for a company in Dammam, capital of Saudi's eastern province.

He was arrested on December 20, 2019 after he posted derogatory messages on Facebook against crown prince Mohammad bin Salman and went on to claim that a Ram temple will be built in the holy city of Makkah too just like in Ayodhya where the Babri mosque was demolished.

Fearing legal action, he later posted a video pleading for forgiveness. “I have committed a mistake. Please forgive me. I will never upload any such posts again," he is seen saying in the video.

After his arrest, his roommate, who happens to be a Pakistani, has reportedly made several attempt to contact him, but in vain. He also has approached many Indian and Saudi authorities in his bid to get Bangera out of prison, sources said.

The Saudi authorities have not even responded to the messages of Indian Ministry of External Affairs. "We've made many efforts to contact the Saudi authorities but they haven't responded,” MEA sources said.

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fairman
 - 
Monday, 3 Feb 2020

There can be many such people in the Kingdom. 

 

They should be identified and treated in the same way.

These are real terrorists, keep him few years in jail,  they should not be let free. Otherwise they will forget and commit again.

May God help us.

 

 

Suresh SS
 - 
Monday, 3 Feb 2020

Well done Saudi Authorities, this kind of mentality should be eleminated even any whare in any country we have many BJP dogs barking nonsence always all should be eleminated.

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News Network
January 7,2020

Bengaluru, Jan 7: Karnataka Chief Minister BS Yediyurappa on Monday said the much-awaited cabinet expansion will take place in about a week to 10 days and that he wants to complete the exercise before his proposed visit to Davos to attend the World Economic Forum meet later this month.

"Cabinet expansion has to be done in a week or 8-10 days. There is also information that Amit Shah will be coming to Bengaluru on January 16 or 18. Before that I will go to Delhi and get things cleared and will expand the cabinet at the earliest," Mr Yediyurappa said.

Speaking to reporters in Bengaluru, he said he wanted to complete the exercise before his Davos visit.

"I will make all efforts to expand the cabinet before that," he said.

With Mr Yediyurappa making it clear that 11 of the disqualified JDS-Congress MLAs who got re-elected in the December 5 bypolls on BJP tickets will be made ministers, lobbying has been on within the party for the remaining ministerial berths.

Currently, there are 18 ministers, including the Chief Minister, in the cabinet that has a sanctioned strength of 34.

Cabinet expansion will not be an easy task for the Chief Minister as he will have to strike a balance by accommodating the victorious disqualified legislators as promised and also make space for the old guards, upset at being "neglected" in the first round of the induction exercise.

He also has to give adequate representation to various castes and regions in his cabinet and also deal with the allocation of key portfolios.

The Chief Minister, who has indicated that the ministry expansion may take place any time after Sankranti, is likely to travel to Davos on January 20, according to sources.

BS Yediyurappa, along with Union ministers Piyush Goyal and Mansukh Mandaviya, as well as Chief Ministers Amarinder Singh, Kamal Nath, are expected to join over 100 Indian CEOs at Davos in Switzerland later this month for the WEF's 50th annual meeting, which will be attended by thousands from across the globe.

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News Network
March 1,2020

Udupi/Mangaluru, Mar 1: A total of twenty leaplings were born in the hospitals of the Udupi and Dakshina Kannada (DK) districts on Saturday, February 29, district health department said on Sunday.

According to the district health department, sixteen babies were born in DK district while Udupi district saw four births. More boys than girls were born in DK (12–4) and it was the inverse in Udupi district (3–1).

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