Tamarind seed protein has potential to cure Chikungunya: IIT-R study

Agencies
November 14, 2018

New Delhi, Nov 14: Two professors at Indian Institute of Technology (IIT) Roorkee claimed to have discovered a protein in tamarind seeds that has anti-viral properties and can potentially be used to develop medication for chikungunya.

The research group at IIT Roorkee has filed a patent for an antiviral composition containing this tamarind antiviral protein and is now developing tamarind-based therapeutic agents for chikungunya.

"Tamarind is known for various medicinal properties in India and is a excellent Ayurvedic food. The fruits, seeds, leaves and roots bark of the tamarind tree have been used to treat abdominal pain, diarrhoea and dysentery, bacterial infections and parasitic infestations, wounds, constipation and inflammation," said one of the professors, Shaily Tomar.

Lectin, a diverse group of proteins derived from plant sources, are known to bind to glycan sugars. Its use as antiviral has been extensively studied for a range of viruses, including HIV and HPV.

The IIT professors, in a study, have shown that a lectin derived from tamarind seeds bind to glycans or sugar molecules having N-acetylglucosamine (NAG) on the capsule of viruses, thereby preventing the entry of the virus into the host cells.

The researchers have isolated lectin from tamarind seeds using chromatography and have studied the binding of the lectin molecules to the glycan in the viral capsule by a process called Enzyme-Linked ImmunoSorbent Assay (ELISA).

"Not only did the chikungunya virus lose 64 per cent of its infectivity on treatment with the lectin, but the levels of viral RNA in the cells were also found to reduce to nearly 45 per cent. This study has, for the first time, evaluated the antiviral use of tamarind seed-derived lectin having specificity for NAG and assessed its ability to block the entry step of the virus," Tomar added.

"Antiviral drugs and vaccines against most alphaviruses, including chikungunya are still not available in the market, and preventive measures are currently the only route to managing diseases caused by such viruses," said professor Pravindra Kumar, who is also part of the research.

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News Network
April 5,2020

Thieves broke into an MSIL liquor outlet at Kuthar Nityanandanagara on the outskirts of Mangaluru and decamped with liquor worth Rs 1 lakh. The incident came to light on Friday morning. 

The outlet belongs to Purushotham Pilar. 

Before committing the crime, the thieves had hung a cloth in front of the shop shutter of the outlet to ensure that no one could notice the crime. They also stole DVR of the CCTV the was installed. 

On noticing that outlet was open, many people had even come to purchase liquor. The police took all those who had visited the outlet to purchase to the task and chased them away.

The thieves also stole 10 packets of cigarettes from a paan shop situated adjacent to the MSIL outlet.

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News Network
April 18,2020

Bengaluru, Apr 18: Amid fears that people from the unorganised sector are running out of cash to meet their daily expenses, the Karnataka government said there was no data available for such labourers, who can be provided financial assistance under the direct benefit transfer (DBT) scheme.

"The government does not have data of people in the unorganised sector such as drivers, farmers, domestic help and others. If we have to deposit directly into their account, we need data..," State Labour minister A Shivaram Hebbar told reporters.

The minister said a situation borne out of the COVID-19, where the entire nation has been lockdown was never anticipated.

To him, the pandemic has given an opportunity to gather information about the unorganised sector.

"This COVID-19 has taught the department and the workers a lesson that we should be prepared for a situation like this. We have learnt that all the information about labourers should be available with the labour department," Hebbar conceded.

The minister opined that the department should have had the list during the good times but nobody bothered to have it.

"During the good times nobody bothered about it -- neither they (beneficiaries) asked for it, nor we thought of it.," Hebbar said.

Now that the pandemic has struck, the government is focusing only on not letting anyone starve to death.

A three-level preparation has been made -- at the village level, Taluk level and the city level, the minister said.

Village anganwadis have been stuffed with food items to be cooked for the needy, whereas in Taluk level, government hostels have been turned into shelters for the labourers, he said, noting that lakhs of philanthropists in cities have come forward to feed the people from unorganised sector.

"The basic objective of our government is that no one should starve to death. The issue of organised or unorganised sector comes next," he explained.

On the fear of large-scale retrenchment, the minister said notices have been served on all the industries that no one should be expelled from the job.

However, Hebbar underlined that the industrialists today are as much in distress as the workers and his department was taking into account everyone's concern.

A decision will be taken in this connection by the government in the next two days, to provide assistance to small enterprises to keep them afloat.

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News Network
June 9,2020

Bengaluru, Jun 9: Two grassroots level workers of the Bharatiya Janata Party (BJP) on Tuesday filed their nominations for the Rajya Sabha elections from Karnataka, Chief Minister and senior BJP leader BS Yediyurappa said.

"Eranna Kadadi and Ashok Gasti have filed nominations for the Rajya Sabha elections from Karnataka. It is only in BJP that grassroots level workers are given recognition," Yediyurappa told reporters here.

The elections to fill the vacant 18 Rajya Sabha seats from seven states are scheduled to be held on June 19. Elections to four Rajya Sabha seats will be held in Karnataka.

"The core committee of the party had recommended a few names. Afterwards, the party's all-India president consulted with me. Finally, these two names were finalised," Yediyurappa said.

The nominations will be scrutinised on Wednesday and the last date for withdrawal of nomination is June 12.

Notably, the Janata Dal (Secular) on Monday announced that party supremo and former Prime Minister HD Deve Gowda has decided to contest the forthcoming Rajya Sabha elections.

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