Teenagers smoke to lose weight: survey

October 14, 2016

Washington, Oct 14: Shunning popular beliefs that people smoke cigarettes because they're addicted to the nicotine, a recent study shows that among US teens who are frequent smokers, 46 percent of girls and 30 percent of boys smoke to control their weight.

smokeAnd smoking to lose weight is significantly more common among teens, who feel they must slim down.

Girls who said they were "much too fat" were nearly 225 percent more likely to smoke to lose weight than girls who said their weight was about right. For boys, being overweight was less of a predictor for smoking, perhaps because they feel less pressure from society to lose weight than girls do.

Even so, boys who said they were "much too fat" were nearly 145 percent more likely to smoke for weight loss than boys who said their weight was about right.

Expert in the field John Cawley said, "This helps us better understand why people choose to engage in risky health behaviors. It's not always just about the immediate pleasure or enjoyment; sometimes it's a means to another end."

Teen smoking is a particularly worrisome public health concern because the people, who start smoking by their early 20s, are likely to continue in adulthood. And tobacco is the No. 1 preventable cause of death in the United States.

"One hundred years ago, what we mostly died of were infectious diseases, like tuberculosis and influenza. Now we die from our own choices," said Cawley.

Adding, "At all levels of government, there's a realization that we need to find ways to stop teenagers from developing poor health habits."

The researchers analyzed data from the Health Behavior in School-aged children survey from 2001-01 and 2005-06 for nearly 10,500 U.S. schoolchildren, who were 11, 13 or 15 years old.

The children reported their heights and weights, which the researchers used to calculate their body mass indexes. The youth also reported their perception of their weight.

When asked "Do you think your body is . ," they responded with either "much too thin," "a bit too thin," "about right," "a bit too fat" or "much too fat." The survey also asked the children whether they had done anything to lose weight, what that action was and whether they smoked and how frequently.

The researchers also found that white teens were more than twice as likely as African-American adolescents to smoke for weight loss. The findings have implications for anti-smoking policies, researchers noted.

The Food and Drug Administration may wish to prohibit cigarette companies from promoting the idea that smoking can help one lose weight, Cawley said.

That's because the more strongly people believe that idea, the less responsive they will be to increased cigarette taxes; that is, they'll be more likely to continue buying cigarettes, even at a higher price, he said.

"There's a strong economic case for taxing cigarettes. It's just that the taxes may not decrease consumption among girls as much as you might hope or think. But if you can break the perceived connection between smoking and weight loss, you may increase their responsiveness to taxes," he said.

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Agencies
January 25,2020

Washington D.C., Jan 25: A new study conducted by a team of researchers reveals why individuals who have a history of early life adversity (ELA) are disproportionately prone to opioid addiction.

The study conducted examined how early adversities interact with factors such as increased access to opioids to directly influence brain development and function, causing a higher potential for opioid addiction.

The study was lead by UCI researchers and was published in Molecular Psychiatry.

Tallie Z. Baram, MD, PhD, the Danette Shepard Chair in Neurological Sciences at the UCI School of Medicine and one of the senior researchers for the study, was on the take that the widely known factor genetics that plays major role in addiction vulnerability, cannot be solely held responsible for the recent rise in opioid abuse.

To further clarify, the researchers simulated ELA in rats by limiting bedding and nesting materials during a short, postnatal period of time.

In female rats, this led to striking opioid addiction-like characteristics including an increased relapse- behaviour, for example.

As observed in addicted humans, the rats were willing to work very hard (pay a very high price) to obtain the drug.

Baram said: "Ultimately, we found that conditions during sensitive developmental periods can lead to vulnerability to the addictive effects of opioid drugs, especially in females, which is consistent with the prevalence of ELA in heroin-addicted women."

These findings can be used to highlight the importance given to sex differences in future ELA-related studies on opioid addiction, and in future prevention or intervention strategies being developed to address the growing opioid crisis.

The study conducted examined how early adversities interact with factors such as increased access to opioids to directly influence brain development and function, causing a higher potential for opioid addiction.

The study was lead by UCI researchers and was published in Molecular Psychiatry.

The study found that unpredictable, fragmented early life environments may lead to abnormal maturation of certain brain circuits, which profoundly impacts brain function and persists into adolescence and adulthood.

Tallie Z. Baram, MD, PhD, the Danette Shepard Chair in Neurological Sciences at the UCI School of Medicine and one of the senior researchers for the study, was on the take that the widely known factor genetics that plays major role in addiction vulnerability, cannot be solely held responsible for the recent rise in opioid abuse.

To further clarify, the researchers implanted ELA in rats by limiting bedding and nesting materials during a short, postnatal period of time.

In female rats, this led to striking opioid addiction-like characteristics including an increased relapse- behaviour, for example.

As observed in addicted humans, the rats were willing to work very hard (pay a very high price) to obtain the drug.

Baram said: "Ultimately, we found that conditions during sensitive developmental periods can lead to vulnerability to the addictive effects of opioid drugs, especially in females, which is consistent with the prevalence of ELA in heroin-addicted women."

These findings can be used to highlight the importance given to sex differences in future ELA-related studies on opioid addiction, and in future prevention or intervention strategies being developed to address the growing opioid crisis.

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Agencies
June 10,2020

Early treatment with the antiviral drug remdesivir has been found to reduce viral load and prevent lung disease in macaques infected with SARS-CoV-2 that causes COVID-19, according to a study.

The findings, published in the journal Nature on Tuesday, support the early use of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia.

Researchers from the National Institutes of Health in the US noted that remdesivir has broad antiviral activity and has been shown to be effective against infections with SARS-CoV and MERS-CoV in animal models.

The drug is being tested in human clinical trials for the treatment of COVID-19, they said.

Researcher Emmie de Wit and colleagues investigated the effects of remdesivir treatment in rhesus macaques, a recently established model of SARS-CoV-2 infection.

Two sets of six macaques were inoculated with SARS-CoV-2.

One group was treated with remdesivir 12 hours later -- close to the peak of virus reproduction in the lungs -- and these macaques received treatment every 24 hours until six days after inoculation.

In contrast to the control group, the researchers found that macaques that received remdesivir did not show signs of respiratory disease, and had reduced damage to the lungs.

Viral loads in the lower respiratory tract were also reduced in the treated animals; viral levels were around 100 times lower in the lower-respiratory tract of remdesivir-treated macaques 12 hours after the first dose, they said.

The researchers said that infectious virus could no longer be detected in the treatment group three days after initial infection, but was still detectable in four out of six control animals.

Despite this virus reduction in the lower respiratory tract, no reduction in virus shedding was observed, which indicates that clinical improvement may not equate to a lack of infectiousness, they said.

Dosing of remdesivir in the rhesus macaques is equivalent to that used in humans, the researchers noted.

They cautioned that it is difficult to directly translate the timing of treatment used in corresponding disease stages in humans, because rhesus macaques normally develop only mild disease.

However, researchers said the results indicate that remdesivir treatment of COVID-19 should be initiated as early as possible to achieve the maximum treatment effect.

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