Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
IFF getting credit by the main person from Ullal struggled a lot behind this issue. nobody remember him. Finally the credit goes to IFF
Mashaallah great job done by iff
Masha allah great job done by. IFF.
ALHAMDULILLAH...
Tremended work done by INDIA FRATERNITY FORUM.
financially support from donors is highly appreciated.
may ALLAH accept all good deeds from all.
One of the noble act by India Fraternity Forum. And we must appreciate the NRI business personalities who responded positively to IFF call. Thank you CDi for the news..!!
From the bottom of my heart I really thank and pray with Almighty Allah to bless each of them whoever helped these fellow brothers to get release from the jail.
May Allah accept all our good deeds- Ameen.
Well done IFF and team! Following up a case for last 7 years is not an easy task. It is victory for team work, determination and patience.
Financial support from donors and victims family is highly appreciated.
May Allah accept the good deed from all.
Masha Allah. Great job
Masha Allah .great job
Al Hamdulillah after so many years of relentless efforts from IFF finally Allah has helped us in getting positive result. Hats off to IFF, we are with you.
Really great work May Allah accept our good deeds
Dear CD
Why did u edited the report. It seems that u dont want to highlight the efforts of Iff brothers in the report
My special thanks to India fraternity forum and business man for this great noble cause. Keep it up.
Great work by India Fraternity Forum (IFF), Jeddah, May Allah reward for your humanitarian Service. We have to appreciate IFF efforts because they are following this case since more than 7 years for this particular case. IFF team achieved this goal by the grace of Allah and well wishers as well as Indian Consulate service.
My special thanks to IFF and business man who supported for this great noble cause. Allah will bless you for this great job. Keep it up.
EIFF good work
http://www.daijiworld.com/news/news_disp.asp?n_id=377876
http://www.daijiworld.com/news/news_disp.asp?n_id=377876
Correct report ..
IFF good work , keep the good work
IFF doing a great work in GCC , ..
Alhamdulilha may Allah reward all the people who worked for it and even the donors who supported well specially Indian Faternity Forum.
Great Work by I.F.F
Great job done IFF jeddah Team..
Keep it up...
Great work by iff because struggling behind the case from 7 year is not so easy. This case finalized by iff without any political support . And one who donated for this will be appreciated and will get reward in sha Allah
Al hamdulillah
Tremended work done by IFF from last 7 years they are following case in filed work documentation every thing great...without IFF efforts it was not possible to release this case..they have done major case like Nelaydi Sulaiman 3 years back got released and Kakkepadau Tahaliah Case they fought with insurance company 5 years back.. finally insurance payed Orphans family SR 1.25 lakh. may almighty allah accept good deeds...special thanks to welwisher team
Good job IFF
Iff is doing great work throughout gulf countries. As I closely watched social work which doing by iff for Indian expatriates is really good and appreciable. In above case Aslo iff have done wonderful job and get great success to release them from jail. Congratulation to iff to get great success. Keep on serve Indian community. Good luck
Great work IFF....
Good work.
Alhamdulillah
Masha Allah Good job IFF
Keep it up IFF. Your effort is really appreciable.
Thanks IFF, Hats off for your efforts, several tried but you guys succeed. some times need extra power than money, hats off again.
Congrats.. Thanks to the authority
Should thank to the authority or the people who tried for the release made that possible
Allah's grace. Those who are believing in Allah, will not get suffered.
Al Hamdulillah
THANKS FOR IFF AND BUSINESS MAN
Congrats. Al Hamdulillah. May almighty reward all the donors including CD boss. the efforts of IFF is also appreciable.
Good news.
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