Terror theory for missing Malaysian jet; floating door spotted

March 10, 2014

Floating_doorKuala Lumpur, Mar 10: Vietnamese authorities on Sunday said they had spotted what looked like one of the doors of the missing Boeing 777 jetliner that crashed into the sea between Malaysia and Vietnam a day and a half ago. What caused the crash remained a mystery, even as authorities were checking out the identities of two passengers who were flying on stolen passports. A possible terror attack, or suicide mission, however, remained in the realm of speculation as no evidence has been found and no group has claimed responsibility so far.

Malaysia's air force chief Rodzali Daud said radar indicated that the plane may have turned back, but did not give further details on which direction it went or how far it veered off course. "We are trying to make sense of this," Daud said at a news conference. "The military radar indicated that the aircraft may have made a turn back, and in some parts this was corroborated by civilian radar."

The plane, which was carrying 239 people — five Indians among them — lost contact with ground controllers off Vietnam after leaving Kuala Lumpur early Saturday morning for Beijing. The missing plane apparently fell from the sky at cruising altitude in fine weather, and the pilots were either unable or had no time to send a distress signal — unusual circumstances under which a modern jetliner operated by a professional airline would crash.

A Vietnam army officer was reported in the state-run newspaper as saying searchers in a low-flying plane had spotted an object that looked like a door from the Malaysia Airlines plane. It was found in waters about 90km south of Tho Chu island, in the same area where oil slicks were spotted on Saturday. "From this object, hopefully, (we) will find the missing plane," the officer said. Two ships from the maritime police were headed for the site.

Malaysia Airlines chief executive Ahmad Jauhari Yahya said pilots are supposed to inform the airline and traffic control authorities if the plane does a U-turn. "From what we have, there was no such distress signal or distress call per se, so we are equally puzzled," he said.

Authorities were checking on the identities of the two passengers who boarded the plane with stolen passports. On Saturday, the foreign ministries in Italy and Austria said the names of two citizens listed on the flight's flyers' list matched the names on two passports reported stolen in Thailand. "I can confirm that we have the visuals of these two people on CCTV," Malaysian transport minister Hishammuddin Hussein said at a news conference late on Sunday, adding that the footage was being examined. "We have intelligence agencies, both local and international, on board."

"Our focus now is to find the aircraft," he said, adding that finding the plane would make it easier for authorities to investigate any possible foul play.

Interpol confirmed that at least two stolen passports used by passengers on the plane were registered in its databases. It said no one had checked the databases, but added that most airlines and countries do not usually check for stolen passports. Hishammuddin said only two passengers had used stolen passports, and that earlier reports that the identities of two others were under investigation were not true.

In addition to the plane's sudden disappearance, which experts say is consistent with a possible onboard explosion, the stolen passports have strengthened concerns about terrorism as a possible cause. Al-Qaida militants have used similar tactics to try and disguise their identities.

Still, other possible causes would seem just as likely at this stage, including a catastrophic failure of the plane's engines, extreme turbulence, or pilot error or even suicide. Establishing what happened with any certainty will need data from flight recorders and a detailed examination of any debris, something that will take months if not years.

The multinational search for the missing plane is on. A total of 34 aircraft and 40 ships have been deployed to the area by Malaysia, Thailand, Australia, Singapore, Indonesia, China and the United States, in addition to Vietnam's fleet. Vietnamese air force jets spotted two large oil slicks Saturday, but it was unclear whether they were linked to the missing plane.

Two-thirds of the jet's passengers were Chinese. The rest were from elsewhere in Asia, North America and Europe.

After more than 30 hours without contact with the aircraft, Malaysia Airlines told family members they should "prepare themselves for the worst", Hugh Dunleavy, the commercial director for the airline, told reporters.

Finding traces of an aircraft that disappears over sea can take days or longer, even with a sustained search effort. Depending on the circumstances of the crash, wreckage can be scattered over many square kilometers (miles). If the plane enters the water before breaking up, there can be relatively little debris.

Malaysia Airlines has a good safety record, as does the 777, which had not had a fatal crash in its 19-year history until an Asiana Airlines plane crashed last July in San Francisco, killing three passengers.

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News Network
April 10,2020

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

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News Network
June 24,2020

Islamabad, Jun 24: A plane crash which killed 97 people in Pakistan last month was because of human error by the pilot and air traffic control, according to an initial report into the disaster released Wednesday.

The Pakistan International Airlines (PIA) plane came down among houses on May 22 after both engines failed as it approached Karachi airport, killing all but two people on board.

"The pilot as well as the controller didn't follow the standard rules," the country's aviation minister Ghulam Sarwar Khan said, announcing the findings in parliament.

He said the pilots had been discussing the coronavirus pandemic as they attempted to land the Airbus A320.

"The pilot and co-pilot were not focused and throughout the conversation was about coronavirus," Khan said.

The Pakistani investigation team, which included officials from the French government and the aviation industry, analysed data and voice recorders.

The minister said the plane was "100 percent fit for flying, there was no technical fault".

The county's deadliest aviation accident in eight years came days after domestic commercial flights resumed following a two-month coronavirus lockdown.

Many passengers were on their way to spend the Muslim holiday of Eid al-Fitr with loved ones.

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News Network
March 4,2020

Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

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