Those who hesitate to vote for BJP are pro-Pak, says K S Eshwarappa

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Thiruvananthapuram, Apr 24: Kerala Chief Minister Pinarayi Vijayan on Thursday said that there is no community spread or the expected phase three spread of coronavirus in the state so far but the threat continues.

Speaking to media persons here on Thursday, Vijayan said that Kasargod, Kannur, Kozhikode, and Malappuram districts will be in the red zone with full restrictions.

"All the other ten districts in the State will be in the orange zone. With the detection of new cases today, the status of Kottayam and Idukki districts have been changed from green to orange. The district administration will decide on the hotspot areas to be closed," he said.

He said there would be an increase in the number of random tests in the red zones.

"In an effort to confirm that there is no community spread in the State, random antibody tests would be conducted among health workers, police personnel, home delivery persons, volunteers and migrant labourers," he added.

The Chief Minister said that COVID-19 labs set up at the Pariyaram Government Medical College at Kannur and the Kottayam Medical College have got the approval from the ICMR for coronavirus testing. The lab at Kannur Medical College will start functioning from Friday.

The UV sterilised lab, spread over 2,200 sq ft is equipped with four real-time PCR machines. In the first phase, this lab will be able to do 15 tests per day, which will be gradually increased to conduct 60 tests in the next phase.

"With the opening of these two new labs, tests to detect COVID-19 will be conducted in 14 government labs in Kerala. Apart from this, there are two private labs also in Kerala which are doing these tests. Since the number of coronavirus cases is again increasing in the State, the government has decided to procure ten real-time PCR machines to ramp up testing," he added.

Palakkad, Jun 1: An 11-month-old boy, whose parents are placed under COVID-19 quarantine, drowned in a bucket of water in Chalissery at Palakkad district.

The toddler Muhammed Nisan was the son of Muhammad Sadiq. The parents of the child are under home quarantine after Sadiq's brother, who is living in the same home was tested positive of COVID-19.

The child was found dead in a bucket of water kept in the bathroom on Saturday around 10 pm.

Chalissery police said that ''further actions will be taken only after the test result comes out. We have filed an unnatural death case on this.''

Since the family has been quarantined, the body of the baby has been shifted to the Thrissur Medical College for COVID-19 testing.