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Bengaluru, Jan 3: Former Karnataka chief minister and Congress leader Siddaramaiah on Friday criticised Prime Minister Narendra Modi and said that 90 per cent of the promises made by him remain unfulfilled.

"He (Prime Minister Modi) had promised that in 2020 the economy will be doubled, but only their troubles have doubled. He just lied. 90 per cent of the promises made by Modi have remained unfulfilled," Siddaramaiah told media here.

Siddaramaiah's remarks come at a time when Prime Minister Modi is on a two-day visit to the state.

"In August, there was severe flood in state, he didn't visit Karnataka at that time. Flood situation was in 23 districts. Prime Minister will tweet for small issues. But at the time of severe flood he didn't even tweet. In 2009, Manmohan Singh was the Prime Minister. He did aerial survey of the state and announced Rs 1500 crore relief on spot," Siddaramaiah said.

"This time the estimated damage due to flood is more than Rs 1 lakh crores," he said.

He went on to say, "Prime Minister came to witness Chandrayaan-2. He did not give time to Chief Minister and ministers and opposition party to meet him and discuss about floods."

"When I was the Chief Minister, the Prime Minister visited the state two times. Prime Minister had told at the time of inauguration of food park that there will be 10,000 direct employment and 25,000 employment. But nothing has happened till now," Siddaramaiah said.

Besides the Prime Minister, Siddaramaiah also criticised Chief Minister BS Yediyurappa.

"In last election, Prime Minister had told that, if BJP comes to power in Centre and state, there will be development. But nothing has happened. Chief Minister and ministers should have spoken to the Prime Minister about relief funds. The central government should have announced it as National disaster... That's why I called BS Yediyurappa as weak Chief Minister," Siddaramaiah said.

"He had said if BJP is in power at the centre and state, doors of fortune of the state will be opened. People trusted him and gave 25 seats in Lok Sabha elections. But now, he doesn't even open the doors of his house for his party leaders," he said.

Congress leader further cornered the Prime Minister over his address in Tumkuru Mutt on Thursday and said, "We admit Pakistan is an evil country. But what are you doing about minorities in our country? You are bringing law against the minorities. Is that right? And you give speech about these things in front of young children."

Prime Minister Modi is on a two-day visit to Karnataka and is attending several events as part of his official engagements.

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.