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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Jul 16: Karnataka chief minister BS Yediyurappa on Tuesday said he would request Prime Minister Narendra Modi for more relaxations, as he made it clear that Covid-19 lockdown measures were not required in the state anymore.

"The lockdown is not required for Karnataka, we will request for more relaxations," Yediyurappa said in response to a question about video conferencing with the Prime Minister.

Speaking to reporters here, he said, "I will request him (PM) to make way for- people to lead a normal life and for the improvement in the economic situation."

Several services such as metro, theatres, gyms, swimming pools, bars among others continue to remain restricted under unlock 1.0 that is currently in place.

Modi is scheduled to hold a video conference with chief ministers of various states on Tuesday and Wednesday. Yediyurappa is scheduled to take part in the video conferencing on Wednesday.

The chief minister, who took part in the special pooja organised at Shankar Math here to pray for the control of Covid-19, said, the government was making all efforts to control the spread.

"We are taking strong measures and all of us should fight this together," he said, as he highlighted that the government has released the financial assistance amount that was announced for farmers, and was ensuring that it reaches them.

Bengaluru, May 24: Karnataka has conducted 2.03 lakh tests across the 57 Indian Council of Medical Research (ICMR) COVID-19 testing labs till Sunday morning, said the state Minister of Medical Education Dr K Sudhakar.

He informed that the state has doubled the number of tests in just 16 days after clocking 1 lakh tests on May 8.

"After clocking 1 lakh tests on May 8, we have doubled the number of tests in just 16 days. As on this morning, we conducted 2.03 lakh tests across our 57 ICMR COVID-19 testing labs. I congratulate doctors and lab technicians on this achievement," Sudhakar tweeted.

As many as 1,743 people have been detected positive for coronavirus in the state, of which 597 have been cured and discharged and 41 have succumbed to the infection, as per the Union Health Ministry.