'Uppi' without 'i' is Upendra's new party

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Mangaluru, Mar 29: The state government has lifted the restrictions on the movement of chicken and eggs, thus ensuring the availability of protein-based nutrition to consumers.

Due to the 21-day lockdown in the State, police and other regulatory authorities were not allowing movement of poultry products, which not only had affected the entire poultry sector but also the consumers. The Karnataka Poultry Farmers and Breeders Association (KPFBA) had made a representation to the government to lift the restrictions.

The Secretary of Animal Husbandry and Fisheries, A B Ibrahim in a circular dated March 27, 2020 night , said that the minimal husbandry sector came under essential services and is given exemption during the lockdown period. He cited the letter which provides for the exemption, issued by the Government of India Home Secretary and the Union Joint Secretary of Animal Husbandry and Dairying.

Mangaluru, Apr 4: The mother and grandmother of the 10-month-old baby boy, under treatment at a private hospital in Deralakatte here for COVID-19 infection, tested negative.

Doctors at the hospital said the condition of the infant, who was admitted with an acute respiratory infection, was stable and there had been a good response to the treatment being given in isolation.

The child, hailing from Sajipanadu Village in Bantwal Taluk was admitted to a hospital at Deralakatte in Mangaluru for treatment on March 23 as it had developed respiratory problems. 

On March 24, the child’s condition worsened and hence his throat swabs was sent for COVID-19 testing. On March 27, reports of the tests confirmed that the child was infected with COVID-19.

Health authorities are of the view that the baby might have contracted the disease when the family travelled recently to Kasaragod in Kerala, a district identified as a hotspot for Coronavirus.