US allows UN denounce Israeli settlements

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

The head of the World Health Organisation on Tuesday warned the novel coronavirus was a "very grave threat" for the world as he opened a conference to combat the epidemic.

"With 99% of cases in China, this remains very much an emergency for that country, but one that holds a very grave threat for the rest of the world," Tedros Adhanom Ghebreyesus said in Geneva.

Some 400 scientists will review how the virus is transmitted and possible vaccines at the two-day forum.

"What matters most is stopping the outbreak and saving lives. With your support, that's what we can do together," Tedros said.

The virus, first identified in China on December 31, has killed more than 1,000 people, infected over 42,000 and reached some 25 countries.

Participants will also discuss the source of the virus, which is thought to have originated in bats and reached humans via another animal such as snakes or pangolins.

There is no specific treatment or vaccine against the virus, which can cause respiratory failure.

Tedros, who has repeatedly urged countries affected to share their data, called for global "solidarity".

"That is especially true in relation to the sharing of samples and sequences. To defeat this outbreak, we need open and equitable sharing, according to the principles of fairness and equity," he said.

"We hope that one of the outcomes of this meeting will be an agreed roadmap for research around which researchers and donors will align," Tedros said.

Several companies and institutes in Australia, China, France, Germany and the United States are racing to develop a vaccine -- a process that normally takes years.

Asked whether scientists from Taiwan would be allowed to take part in this week's Geneva conference, WHO officials said that they would do so but only online -- along with colleagues from other parts of China.

While the WHO does not deal with Taiwan directly and only recognises Beijing, Taiwan was often allowed to attend annual assemblies and sideline meetings as an observer.

But in recent years it has been frozen out as Beijing takes an increasingly combative stance towards democratic Taiwan, which it considers its own territory.

New Delhi, May 28: Twitter CEO Jack Dorsey today reinforced his stance on pointing out "incorrect or disputed information about elections globally", a day after US President Donald Trump threatened to shutter social media over Twitter's actions on his posts.

Mr Dorsey appealed to "leave our employees out of this" as the face-off with Mr Trump is likely to escalate.

"Fact check: there is someone ultimately accountable for our actions as a company, and that's me. Please leave our employees out of this. We'll continue to point out incorrect or disputed information about elections globally. And we will admit to and own any mistakes we make," Mr Dorsey tweeted.

"This does not make us an 'arbiter of truth.' Our intention is to connect the dots of conflicting statements and show the information in dispute so people can judge for themselves. More transparency from us is critical so folks can clearly see the why behind our actions," said the Twitter CEO.

Fact check: there is someone ultimately accountable for our actions as a company, and that's me. Please leave our employees out of this. We'll continue to point out incorrect or disputed information about elections globally. And we will admit to and own any mistakes we make.

— jack (@jack) May 28, 2020

"Per our Civic Integrity policy (https://help.twitter.com/en/rules-and-policies/election-integrity-policy), the tweets yesterday may mislead people into thinking they don't need to register to get a ballot (only registered voters receive ballots). We're updating the link on

@realDonaldTrump tweet to make this more clear," Mr Dorsey tweeted.

Twitter had tagged two of Mr Trump's tweets in which he claimed that more mail-in voting would lead to what he called a "rigged election" this November. There is no evidence that attempts are being made to rig the election, and under the tweets Twitter posted a link which read: "Get the facts about mail-in ballots."

Five states in the US already conduct elections primarily by mail-in vote: Utah, Colorado, Hawaii, Washington and Oregon.

For years, Twitter has been accused of ignoring the US President's violation of platform rules with his daily, often hourly barrages of personal insults and inaccurate information sent to more than 80 million followers, news agency AFP reported.

But Twitter's slap on the wrist was enough to drive Mr Trump into a tirade - on Twitter - in which "Republicans feel that Social Media Platforms totally silence conservatives voices. We will strongly regulate, or close them down, before we can ever allow this to happen," Mr Trump said.

He said that an increase in mail-in ballots - seen in some states as vital for allowing people to avoid crowds during the COVID-19 pandemic - will undermine the election.

"It would be a free for all on cheating, forgery and the theft of Ballots," wrote Mr Trump, whose re-election campaign has been knocked off track by the coronavirus crisis. His torrent of angry tweets earned a top-10 trending hashtag: #TrumpMeltdown.

Facebook chief Mark Zuckerberg also waded in to the row, telling Fox News that his social network - still the biggest in the world - has a different policy. "I just believe strongly that Facebook should not be the arbiter of truth of everything that people say online," Mr Zuckerberg said in a snippet of the interview posted online Wednesday by Fox.

"I think, in general, private companies, especially these platform companies, shouldn't be in the position of doing that," he said.

 he claimed that the political right in the US is being censored.

"Republicans feel that Social Media Platforms totally silence conservatives voices. We will strongly regulate, or close them down, before we can ever allow this to happen," Mr Trump said.

He said that an increase in mail-in ballots - seen in some states as vital for allowing people to avoid crowds during the COVID-19 pandemic - will undermine the election.

"It would be a free for all on cheating, forgery and the theft of Ballots," wrote Mr Trump, whose re-election campaign has been knocked off track by the coronavirus crisis. His torrent of angry tweets earned a top-10 trending hashtag: #TrumpMeltdown.

Facebook chief Mark Zuckerberg also waded in to the row, telling Fox News that his social network - still the biggest in the world - has a different policy. "I just believe strongly that Facebook should not be the arbiter of truth of everything that people say online," Mr Zuckerberg said in a snippet of the interview posted online Wednesday by Fox.

"I think, in general, private companies, especially these platform companies, shouldn't be in the position of doing that," he said.