US body lauds Obama for his religious freedom remarks in India

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

The Hague, Jun 22: Finding inner peace is crucial for the armed forces and yoga is a beautiful way to find the balance, Dutch Defence Minister Ank Bijleveld has said, thanking India for the "wonderful gift" to the world.

Yoga has been gaining global popularity in recent years for the many benefits it has on one's physiology, psychology and spirituality.

Bijleveld participated in the online International Yoga Day celebrations organised by the Indian Embassy here on Sunday.

"The minister thanked India for the wonderful gift of yoga to the world," a statement issued by the embassy said on Monday.

She said finding inner peace is crucial for a man and woman in uniform and yoga is a beautiful way to find the balance, it noted.

Bijleveld said yoga has formed a part of the training for the Dutch armed forces for the last 15 years and there are 130 yoga instructors.

The representatives of the Dutch Army joined by the Dutch Police personnel demonstrated their yoga skills as part of the online celebrations, the statement said.

The sixth International Yoga Day celebrations was streamed to 145,000 followers of the embassy's Facebook, Twitter, Instagram and YouTube channels as well as on its website. It was also streamed on the website of the non-profit foundation Stichting International Yoga Day.

Ambassador of India to The Netherlands Venu Rajamony inaugurated the celebrations. This was followed by Prime Minister Narendra Modi's video message and 3D animated videos of yoga with him.

The event was participated by a host of prominent Dutch and Indian personalities, including Ambassadors of various countries based in The Hague.

Dutch actress Afke Reijenga, extreme sportsman Wim Hof -- popularly known as 'The Iceman' and singers Charlie Dee and Anouk Maas were amongst the Dutch celebrities who participated in the event, the statement said.

Messages and artistic contributions by spiritual leader Sri Sri Ravi Shankar, internationally acclaimed flautist Pandit Hariprasad Chaurasia, violin maestro L Subramaniam, playback singers Kavita Krishnamurthy and Vijay Prakash, chess grandmaster Viswanathan Anand and film stars Raadhika, Sarathkumar and Bhumika Chawla featured in the programme.

Cricketer Suresh Raina, tennis stars Ramesh Krishnan and Rohan Bopanna, yoga guru and artist Bharat Thakur, Olympic ice skater Vishwaraj Jadeja and Michelin star chef Vikas Khanna also featured in the event.

The programme included a Kathak recital on 'Ayush' choreographed by Dutch choreographer Leo Spreksel and performed by eminent Kathak dancers Hari and Chetna with Sirisha.

It also showcased Hollywood and Bollywood celebrities who have made yoga a part of their lives.

Seoul, Jun 16: North Korea blew up an inter-Korean liaison office on its side of the border on Tuesday, the South's Unification Ministry said, after days of increasingly virulent rhetoric from Pyongyang.

"North Korea blows up Kaesong Liaison Office at 14:49," the ministry, which handles inter-Korean relations, said in a one-line alert sent to reporters.

The statement came minutes after an explosion was heard and smoke seen rising from the long-shuttered joint industrial zone in Kaesong where the liaison office was located, Yonhap news agency reported citing unspecified sources.

Its destruction came after Kim Yo Jong, the powerful sister of North Korean leader Kim Jong Un, said at the weekend: "Before long, a tragic scene of the useless north-south joint liaison office completely collapsed would be seen."

Since early June, North Korea has issued a series of vitriolic condemnations of the South over activists sending anti-Pyongyang leaflets over the border -- something defectors do on a regular basis.

Last week it announced it was severing all official communication links with South Korea.

The leaflets -- usually attached to hot air balloons or floated in bottles -- criticise North Korean leader Kim Jong Un for human rights abuses and his nuclear ambitions.

Analysts say Pyongyang may be seeking to manufacture a crisis to increase pressure on Seoul while nuclear negotiations with Washington are at a standstill.

Earlier Tuesday, North Korea's army said it was "fully ready" to take action against the South, included re-entering areas that had been demilitarised under an inter-Korean agreement.

"North Korea is frustrated that the South has failed to offer an alternative plan to revive the US-North talks, let alone create a right atmosphere for the revival," said Cheong Seong-chang, a director of the Sejong Institute's Center for North Korean Studies.

"It has concluded the South has failed as a mediator in the process."