US Student Otto Warmbier, Said To Be In Coma, Released From North Korea

Agencies
June 14, 2017

Washington, Jun 14: A plane carrying University of Virginia student Otto Warmbier, who had been detained in North Korea for 17 months and was in a coma for most of it, touched down in Cincinnati on Tuesday night.

pyongyang

The 22-year-old's return marks an end to the ordeal that his family has been through, not knowing what had happened to Warmbier since he was sentenced to 15 years in prison with hard labor in March last year. But the fact that he had been kept, comatose, in North Korea for more than a year could worsen the already tense relationship between Pyongyang and Washington.

Friends and well-wishers gathered outside Cincinnati's Lunken Airport Terminal ahead of the anticipated 10 p.m. arrival of the plane carrying Warmbier. Two mobile intensive care units arrived at the private terminal where his family was awaiting his arrival, and drove onto the tarmac when the plane landed.

Two women waiting outside the airport fence held signs: "WELCOME HOME OTTO" and "PRAYERS FOR OTTO," and said they were there to support his family.

Charlotte and David Simons, who said they have been friends of the family for more than 30 years, came to watch his flight come in, too. "We're just here to support Cindy and Fred and the family," Charlotte Simons said.

She was feeling "sick to my stomach for them," she said, thinking of how their son should have been graduating from college this spring.

David Simons was marveling that another country could treat an American like this. "I can only feel for what the family is going through," he said, shaking his head.

After a senior State Department official flew to Pyongyang to demand Warmbier's release on humanitarian grounds, he was flown out in a medical evacuation.

"We get to see our son Otto tonight," Fred Warmbier said in an interview Tuesday morning after his son was evacuated. "We'll be relieved to have him home and are looking forward to surrounding him with people who love him."

Warmbier's parents hadn't heard from or seen him since he was sentenced to 15 years in prison with hard labor in March of last year for attempting to steal a propaganda poster at the end of a five-day tour of North Korea.

But amid the relief, there were also new questions about what happened to him: How did a healthy young man fall into such a deep coma? The North Korean government told his parents that food poisoning was to blame. And how does the Trump administration respond?

Three other American citizens are being detained in North Korea, at a time when Kim Jong Un has been firing missiles and threatening to strike the United States. President Donald Trump has been vowing to exert "maximum pressure" on North Korea to make it abandon its nuclear weapons program but has also dangled the prospect of talks with Kim, whom he called a "smart cookie."

Warmbier was flown out of North Korea on the same day that Dennis Rodman, the controversial former basketball star, arrived for his fifth visit to Pyongyang.

Officials involved in securing Warmbier's release told The Washington Post that it had nothing to do with Rodman's trip to Pyongyang, calling it a "bizarre coincidence" that might have been a deliberate ploy from North Korea to distract from Warmbier's condition.

"Dennis Rodman had nothing to do with the release of Mr. Warmbier," said Heather Nauert, a State Department spokeswoman, adding that the government was "thankful" that he would soon be home in his parents' arms.

She also reiterated the State Department's travel advice against going to North Korea, with which the United States has no diplomatic relations.

"Let me reiterate this: We strongly, strongly suggest that Americans do not go to North Korea," Nauert said.

At the time of his arrest, Warmbier had been on an organized New Year's tour in North Korea, a five-day stopover on his way to Hong Kong for a study-abroad trip.

But on his final night in Pyongyang - New Year's Eve - he apparently went to a staff-only floor of his hotel and attempted to take down a large propaganda sign lauding the regime. He was charged with "hostile acts against the state."

Surrounded by North Korean guards, Warmbier delivered a highly scripted "confession" that appeared to have been written for him, and after an hour-long sham trial in March 2016, he was sentenced to 15 years in prison with hard labor.

He had not been seen in public since, and Swedish diplomats, representing U.S. interests, had been denied consular access to him. Officials involved in negotiations to free Warmbier and another American citizen being detained were told they were being treated as prisoners of war.

During a secret meeting in Oslo last month with Joseph Yun, the State Department's special representative for North Korea, high-level North Korean officials agreed that Swedish diplomats in Pyongyang would be allowed to visit the four Americans imprisoned by the North.

But in Pyongyang, the Swedes were allowed to see only one detainee, and it wasn't Warmbier.

As the Americans continued to push for the Swedish diplomats to see all four, North Korea's ambassador to the United Nations urgently requested a meeting with Yun in New York, according to Trump administration officials, who spoke on the condition of anonymity about the still-secret arrangements. There, North Korean officials told Yun about Warmbier's condition.

He informed Secretary of State Rex Tillerson, who consulted with the president, the officials said.

Yun was instructed to prepare to travel to Pyongyang with the intention of bringing Warmbier back to the United States. A medical team and aircraft were organized, and North Korea was informed that a delegation would travel there.

"It wasn't a situation where they asked," one official said of the U.S. representatives. The North Koreans "were informed that the airplane would land, American and medical officials would get out."

Yun was under orders, which the official said came directly from Trump, to demand to see Warmbier immediately, and, "if he was in bad shape," to demand his immediate release and evacuation on the plane's return flight to the United States.

Yun arrived in Pyongyang early Monday with two American physicians. They were immediately taken to Warmbier. Yun insisted on Warmbier's immediate release on humanitarian grounds, officials said, and the North Koreans agreed.

Tillerson called Trump at 8:35 a.m. Tuesday to inform him that Warmbier was on an airplane en route to the United States, an official said. The last instruction the president left Tillerson was: "Take care of Otto," the official said.

The Warmbier family said they were informed that North Korean officials had told American envoys that their son became ill with botulism soon after his show trial.

The North Korean account, the family said, claimed that Warmbier then fell into a coma after being given a sleeping pill. The Warmbiers said they were told their son has remained in a coma since then.

There was no immediate confirmation from U.S. officials of North Korea's description of his illness - including whether he was stricken with botulism, a potentially fatal disease that is caused by a toxin but is not usually associated with loss of consciousness. U.S. officials in touch with Yun and medical personnel declined to say whether Warmbier remains in a coma or to make any comment on his current medical condition.

North Korean representatives at the United Nations did not respond to repeated requests for comment.

North Korea has woefully inadequate medical care, and it is not clear how North Korean doctors had been caring for Warmbier for more than a year in an unconscious state.

Warmbier was to have graduated last month had he not been detained.

"While the entire University of Virginia community is relieved to learn of Otto's release from North Korea, we are deeply concerned and saddened to learn from his family that he is in a coma," U-Va. President Teresa Sullivan said in a statement Tuesday.

Annabella Vagonis, a family friend from Reston, Virginia, whose daughter was close with Warmbier at U-Va., said, "We were at turns incredulous, shocked, surprised, joyful and sad, all kind of emotions within a nanosecond of each other when we got the news this morning.

"We are so incredibly joyful that he is finally coming home. We are concerned about his overall health and not knowing the details of his being in a coma. We're hopeful that with the excellent medical care that he'll receive that we'll receive some good news once they examine him. "

Sen. Rob Portman, R-Ohio, called Warmbier's arrest and trial "unnecessary and appalling," while lawmakers from Virginia also denounced North Korea's actions.

The three other Americans detained by North Korea remain there.

A former Virginia resident and naturalized American citizen, Kim Dong-chul, was arrested shortly after Warmbier on accusations of espionage and was sentenced to 10 years with hard labor.

In April and May, North Korea detained two other Korean Americans, both of them affiliated with the Pyongyang University of Science and Technology, a private institution run by Korean American Christians.

Previous detainees have been released after visits from high-profile Americans, including former presidents Jimmy Carter and Bill Clinton. But efforts to persuade North Korea to release the men now held had not been successful until Warmbier's release Tuesday.

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News Network
April 10,2020

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

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Agencies
January 11,2020

Washington, Jan 11: US President Donald Trump has signed an executive order imposing another set of crippling sanctions against Iran, targeting several of its top leaders, military commanders, and its infrastructure industry, according to a statement from the White House on Friday.

Trump said the executive order authorises the imposition of sanctions against any individual or entity operating in the construction, manufacturing, textiles, or mining sectors of the Iranian economy or anyone assisting those who engage in this sanctioned business.

The sanctions are the latest in a series of retaliatory measures between the two nations.

Iran's powerful military commander Qasem Soleimani was killed last Friday in US drone strikes, ordered by President Trump, bringing the entire Gulf region close to a full-blown conflict.

Regional tensions remained high after Iran on Wednesday fired missiles at two bases in Iraq used by US forces.

"Today, I am holding the Iranian regime responsible for attacks against United States personnel and interests by denying it substantial revenue that may be used to fund and support its nuclear program, missile development, terrorism and terrorist proxy networks, and malign regional influence," said Trump on Friday, after signing the executive order.

"This order will have a major impact on the Iranian economy, authorising powerful secondary sanctions on foreign financial institutions.

"The Iranian regime has threatened United States military service members, diplomats, and civilians, as well as the citizens and interests of our allies and partners, through military force and proxy groups. The United States will continue to counter the Iranian regime's destructive and destabilising behaviour," the president said.

Trump said the economic sanctions will remain till the Iranian regime changes its behaviour.

Earlier at a White House news conference, Treasury Secretary Steven Mnuchin, along with cabinet colleague Secretary of State Mike Pompeo, said the US will continue its economic and diplomatic sanctions on Iran till Tehran announces it will not pursue the nuclear weapons program and stop its destabilising behaviour in the region.

The eight senior Iranian regime officials against whom sanctions have been issued include Ali Shamkhani, the Secretary of Iran's Supreme National Security Council, Mohammad Reza Ashtiani, the Deputy Chief of Staff of Iranian armed forces, and Gholamreza Soleimani, the head of the Basij militia of the Islamic Revolutionary Guards Corps (IRGC).

The sanction on the Iranian officials would mean denial of visa to the US and seizure of assets, among others.

In addition, the treasury designated 17 Iranian metals producers and mining companies, a network of three China-and Seychelles-based entities, and a vessel involved in the purchase, sale, and transfer of Iranian metals products, as well as in the provision of critical metals production components to Iranian metal producers.

"The United States is targeting senior Iranian officials for their involvement and complicity in Tuesday's ballistic missile strikes," Mnuchin said.

"We are also designating Iran's largest metals manufacturers, and imposing sanctions on new sectors of the Iranian economy including construction, manufacturing, and mining. These sanctions will continue until the regime stops the funding of global terrorism and commits to never having nuclear weapons," he added.

Pompeo told reporters that Iran was planning "broad, large-scale attacks" against American interests in the Middle East, including embassies.

The latest round of sanctions are aimed at striking at the heart of Iran's internal security apparatus, he said.

"The president has been very clear: we will continue to apply economic sanctions until Iran stops its terrorist activities and commits that it will never have nuclear weapons," Mnuchin said.

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Agencies
March 25,2020

Beijing:  Around 5,000 people have signed up for the phase I clinical trial of recombinant novel coronavirus vaccine in Chinese city Wuhan where the virus first emerged late last year.

The recruitment for participants ended this week with nearly 5,000 volunteers signing up for the trial, state-run Beijing News reported on Wednesday.

A single-centre, open and dose-escalation phase I clinical trial for recombinant novel coronavirus vaccine (adenoviral vector) will be tested in healthy adults aged between 18 and 60 years, according to the ChiCTR (China Clinical Trial Register).

The trial, led by experts from the Academy of Military Medical Sciences, gained its approval on March 16 and the research is expected to last half a year.

Requiring at least 108 participants, the trial will be conducted in Wuhan, capital of Hubei province, the region worst-affected by the virus in the country, state-run China Daily reported.

Participants will experience 14-day quarantine restrictions after being vaccinated and their health condition will be recorded every day.

Chinese scientists are hastening the development of COVID-19 vaccines through five approaches --- inactivated vaccines, genetic engineering subunit vaccines, adenovirus vector vaccines, nucleic acid vaccines and vaccines using attenuated influenza virus as vectors.

So far, most teams are expected to complete preclinical research in April and some are moving forward faster, Wang Junzhi, an academician with the Chinese Academy of Engineering said.

Wang noted that research and development of COVID-19 vaccines in China is not slower than foreign counterparts and has been carried out in a scientific, standardised and orderly way.

China has stepped up the process to finalise vaccines to counter COVID-19 after Kaiser Permanente research facility in Seattle and Washington stole the march and began human trials.

China lifted tough restrictions on the Hubei province on Wednesday after a months-long lockdown as the country reported no new domestic cases.

But there were another 47 imported infections from overseas, the National Health Commission said. In total, 474 imported infections have been diagnosed in China -- mostly Chinese nationals returning home.

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