American mathematicians solve Ramanujan's “deathbed” puzzle

[email protected] (The Hindu)
December 30, 2012

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London, December 30: American researchers claim to have solved a cryptic formula that renowned mathematician Srinivasa Ramanujan believed came to him in dreams while on his deathbed, the Daily Mail reported on Saturday.

The formula was contained in a letter he wrote to his mentor, the English mathematician G.H. Hardy, from his deathbed in 1920 outlining several new mathematical functions that had never been heard of before, together with a theory about how they worked. It had baffled mathematicians for more than 90 years, but new findings — presented at a conference at the University of Florida last month — reportedly show that Ramanujan's “hunch” about his formula was right — that it could explain the behaviour of black holes.

“We've solved the problems from his last mysterious letters,” said the well-known American mathematician Ken Ono of Emory University.

“For people who work in this area of math, the problem has been open for 90 years … Ramanujan's legacy, it turns out, is much more important than anything anyone would have guessed when Ramanujan died.”

He said the so-called “deathbed puzzle” which, according to Ramanujan, was revealed to him by the goddess Namagiri, may unlock secrets about black holes. “We proved that Ramanujan was right. We found the formula explaining one of the visions that he believed came from his goddess. No one was talking about black holes back in the 1920s when Ramanujan first came up with mock modular forms, and yet, his work may unlock secrets about them,” said Professor Ono.

The Mail said that Ramanujan's letter described several new functions that behaved differently from known theta functions, or modular forms, and yet closely mimicked them.

“Functions are equations that can be drawn as graphs on an axis, like a sine wave, and produce an output when computed for any chosen input or value. Ramanujan conjectured that his mock modular forms corresponded to the ordinary modular forms earlier identified by Carl Jacobi, and that both would wind up with similar outputs for roots of 1,” it said. Nobody at the time understood what the Indian mathematical genius was talking about.

“It wasn't until 2002, through the work of Sander Zwegers, that we had a description of the functions that Ramanujan was writing about in 1920,” Prof. Ono said.

His team, which used modern mathematical tools to solve the puzzle, was “stunned” to find the function could be used even today.

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May 9,2020

London, May 9: Air India's first evacuation flight from London will be taking off for Mumbai today.

The screening of passengers is underway.

"Air India's first evacuation flight from London taking off for Mumbai today at 1200. Flight is 100% booked! Shubh Yatra. Please stay in touch. GoI working to send more evacuation flights!" High Commission of India, London said in a tweet.

On Monday, India announced had that it will begin phased repatriation of its citizens stranded abroad from May 7.

The government said that Air India will operate 64 flights in the first week from May 7 to May 13 to bring back around 15,000 Indian nationals.

On day three of the 'Vande Bharat Mission', flights carrying Indians from the Gulf countries, the United Kingdom, Bangladesh and Malaysia will arrive in India.

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News Network
July 2,2020

Geneva, Jul 2: The World Health Organization (WHO) has estimated the overall number of coronavirus cases globally at 10,357,662, with 508,055 people having died from the disease.

The UN health agency said in the situation report published on late Wednesday that 163,939 new cases had been recorded in the past day, while further 4,188 patients had died.

Americas continue to lead the count with over 5.2 million cases, followed by Europe with more than 2.7 million.

The WHO declared the COVID-19 outbreak a pandemic on March 11.

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March 4,2020

Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

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