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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, jul 6: With coronavirus cases surging and hospitals saturated with patients, the Karnataka government is setting up intensive care units (ICUs) at COVID Care Centres (CCC) in the state for severe cases needing oxygen, Deputy Chief Minister C N Ashwath Narayan said on Sunday.

Covid Care Centres are usually meant for patients who are asymptomatic or have mild symptoms.

"Initially, 10 ICUs will be set up at every CCC in Bengaluru and in other cities and towns across the state subsequently," Narayan said in a statement in Bengaluru.

The state government has set up CCCs at the GKVK campus, the Haj Bhavan and the Art of Living Foundation campus in the city so far. The government has also set up a more than 10,000 bed CCC facility in BIEC, on Tumkur road, on the outskirts of the city.

"About 100 ICUs will be set up soon at the new CCCs opened at the Bangalore International Exhibition Centre (BIEC), Ayurveda College, and Koramangala Indoor Stadium," said Narayan.

The sprawling BEIC in the city's northwest will soon have 10,100 beds for treating Covid patients and asymptomatic cases from state-run hospitals.

The state government has also relieved all Health Department employees from administrative and non-medical duties to depute them at the CCCs.

On complaints about the poor quality of food served to Covid patients and the medical staff, Narayan warned the vendors of cancelling their contracts if they did not supply good quality food as per the guidelines.

The minister also directed the Health Department to ensure adequate supply of drugs and medical equipment to all CCCs and state-run hospitals for treating Covid patients.

With a record 1,925 new cases reported on Sunday, the state's tally touched 23,474, including 13,251 active after 9,847 were discharged (including 603 on Sunday), while 372 succumbed to the infection since March 9, with 37 more deaths on Sunday.

Of the total cases across the state, Bengaluru accounted for 1,235, taking its tally to 9,580, including 8,167 while 145 died so far.