Brisk walking associated with 60-70% lower risk of death in women

Agencies
November 7, 2017

Washington D.C, Nov 7: A study states that more physical activity and higher intensities of exercise could decrease the risk of death in older women from any cause.

Lack of exercise or physical activity is estimated to cause as many deaths each year as smoking.

Current guidelines recommend at least 150 minutes a week of moderate intensity physical activity, or 75 minutes a week of vigorous-intensity aerobic physical activity (or a combination of the two), and muscle-strengthening exercises two or more days a week.

The study, led by investigators at Brigham and Women's Hospital, investigated physical activity of women measured over seven days using a wearable device called a triaxial accelerometer.

Moderate to vigorous intensity physical activity (e.g. brisk walking) was associated with 60-70 percent lower risk of death at the end of the four-year study among the most active women, compared to the least active.

"The fact the physical activity lowers mortality rate is nothing new - we have many studies showing this. However, previous studies have primarily relied on self-reported physical activity, and self-reports tend to be imprecise. Based on these self-report studies, we know that physical activity is associated with a 20-30 percent reduction in mortality rates, comparing the most with the least active. Using device-measured physical activity in the present study, we observed a 60- 70 percent risk reduction larger than previously estimated from self-report studies. For context, non-smokers have about a 50 percent reduction, compared with smokers," stated I-Min Lee, MBBS, ScD, associate epidemiologist at Brigham and Women's Hospital, and first author of the study.

"This study supports current guidelines for physical activity, such as those from the federal government and the American Heart Association, that emphasize moderate-intensity physical activity. It also adds to existing evidence that can inform upcoming physical activity guidelines over time."

This is one of the first studies to investigate physical activity, and a clinical outcome, using the newer generation triaxial wearable devices which have increased sensitivity to recognize physical activity and are capable of more precise measurements than the previously used uniaxial devices, or studies relying on self-reports only.

"We used devices to better measure not only higher intensity physical activities, but also lower intensity activities and sedentary behavior, which has become of great interest in the last few years," stated I-Min Lee, MBBS, ScD.

Data were analyzed from 16,741 participants (average age 72) from the Women's Health Study who wore the device for at least 10 hours a day, on at least four out of seven days.

Light physical activity, such as slow walking, was not associated with lower death rate during the study. Researchers note that light activity may be beneficial for other health outcomes not reported in this paper.

The findings have been published in Circulation.

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Agencies
June 23,2020

The record levels of new daily COVID-19 cases are due to the fact that the pandemic is peaking in a number of big countries at the same time and reflect a change in the virus' global activity, the World Health Organisation said.

At a media briefing on Monday, WHO's emergencies chief Dr Michael Ryan said that the numbers are increasing because the epidemic is developing in a number of populous countries at the same time.

Some countries have attributed their increased caseload to more testing, including India and the US But Ryan dismissed that explanation.

We do not believe this is a testing phenomenon, he said, noting that numerous countries have also noted marked increases in hospital admissions and deaths neither of which cannot be explained by increased testing.

There definitely is a shift in that the virus is now very well established, Ryan said. The epidemic is now peaking or moving towards a peak in a number of large countries.

He added the situation was definitely accelerating in a number of countries, including the US and others in South Asia, the Middle East and Africa.

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Agencies
February 23,2020

Los Angeles, Feb 23: According to researchers, if administered quickly, a common medication that reduces bleeding could be a treatment for bleeding stroke.

The Spot Sign and Tranexamic Acid on Preventing ICH Growth - Australasia Trial (STOP-AUST) was a multicenter, prospective, randomized, double-blind, placebo-controlled, phase 2 clinical trial using the antifibrinolytic agent tranexamic acid in people with intracerebral hemorrhage (ICH).

ICH is a severe form of acute stroke with few treatment options.

Tranexamic acid is currently used to treat or prevent excessive blood loss from trauma, surgery, tooth removal, nosebleeds and heavy menstruation. For this study, one hundred patients with active brain bleeding were given either intravenous tranexamic acid or placebo within 4.5 hours of symptom onset.

Researchers analyzed brain CT scans taken during the 24-hour period after treatment with tranexamic acid or placebo.

Researchers found a trend towards reduced hemorrhage expansion in the group treated with tranexamic acid, especially in those treated within 3 hours of the brain bleed. However, this trend was not statistically significant. The finding was consistent with previous research using the medication.

"Further trials using tranexamic acid are ongoing and focusing on ultra-early treatment - within 2 hours. 

This is where the greatest opportunity for intervention appears to be. Tranexamic acid is inexpensive, safe and widely available. Our results and others provide great impetus for further, focused research using this treatment," Nawaf Yassi said.

Larger trials focused on patient outcomes are required for this therapy to enter routine clinical practice.

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Agencies
February 11,2020

Using smartphone for long hours every day may do you more harm than you can probably think of. Researchers have found that spending a lot of time with the device and on social media may lead to mental distress and suicidality among adolescents.

The findings, published in the journal CMAJ (Canadian Medical Association Journal) contains guidance for physicians, parents and teachers on how to help teenagers manage smartphone and social media use for a healthy balance between sleep, academic work, social activity, interpersonal relationships and online activity.

"Physicians, teachers and families need to work together with youth to decrease possible harmful effects of smartphones and social media on their relationships, sense of self, sleep, academic performance, and emotional well-being," said lead author of the study Elia Abi-Jaoude from Toronto Western Hospital in Canada.

This review of evidence, led by the Hospital for Sick Children (SickKids), focuses on smartphone use and does not consider online gaming.

"For adolescents today, who have not known a world without social media, digital interactions are the norm, and the potential benefits of online access to productive mental health information -- including media literacy, creativity, self-expression, sense of belonging and civic engagement -- as well as low barriers to resources such as crisis lines and Internet-based talking therapies cannot be discounted," the authors wrote.

The researchers recommend that doctors should ask teenagers to reduce social media use rather than eradicate it completely and encourage parents to be part of the conversations.

Parents should discuss appropriate smartphone use with teenagers to determine together how to reduce risks and set boundaries.

A recent poll from the US indicates that 54 per cent of teenagers think they spend too much time on their smartphones and about half said they were cutting back on usage.

"Encouragingly, youth are increasingly recognising the negative impact of social media on their lives and starting to take steps to mitigate it," the authors wrote.

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