Combat anti-microbial resistance soon with smartphones

December 17, 2016

Dec 17: A team of US researchers has developed a diagnostic test for anti-microbial resistance using a smartphone that can help people in remote areas with limited resources conduct routine testing for antimicrobial susceptibility.

microbialAntimicrobial-resistant bacteria are responsible for high-mortality diseases such as pneumonia, diarrhea and sepsis.

The team from the University of California - Los Angeles (UCLA) built a simple and inexpensive smartphone attachment that can conduct automated anti-microbial susceptibility testing.

"This work is important and timely, given that drug-resistant bacteria are increasingly becoming a global threat, rendering many of our first-line antibiotics ineffective," said Aydogan Ozcan, Chancellor's Professor at the UCLA.

The device connects to a smartphone and has a plate that can hold up to 96 wells for testing.

An array of LEDs illuminates the sample and then the phone's camera is used to sense small changes in light transmission of each well containing a different dose selected from a panel of antibiotics.

Images are then sent to a server to automatically perform anti-microbial susceptibility testing and the results are returned to the smartphone in about one minute with a detection accuracy of 98.2 per cent.

"This mobile reader could eliminate the need for trained diagnosticians to perform anti-microbial susceptibility testing, reduce the cost barrier for routine testing and assist in tracking of bacterial resistance globally," said Omai Garner, a team member.

An additional advantage of this technology is the possibility of examining bacterial growth in the presence of a drug at an earlier time point than is currently read.

"This could allow for a more rapid turnaround time of the results to the physician, which might help save lives," added Dino Di Carlo, another team member.

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Agencies
June 8,2020

Washington DC, Jun 8: Astronomers acting on a hunch have likely resolved a mystery about young, still-forming stars and regions rich in organic molecules closely surrounding some of them.

They used the National Science Foundation's Karl G Jansky Very Large Array (VLA) to reveal one such region that previously had eluded detection and that revelation answered a longstanding question.

The regions around the young protostars contain complex organic molecules which can further combine into prebiotic molecules that are the first steps on the road to life.

The regions, dubbed "hot corinos" by astronomers, are typically about the size of our solar system and are much warmer than their surroundings, though still quite cold by terrestrial standards.

The first hot corino was discovered in 2003 and only about a dozen have been found so far. Most of these are in binary systems, with two protostars forming simultaneously.

Astronomers have been puzzled by the fact that, in some of these binary systems, they found evidence for a hot corino around one of the protostars but not the other.

"Since the two stars are forming from the same molecular cloud and at the same time, it seemed strange that one would be surrounded by a dense region of complex organic molecules and the other wouldn't," said Cecilia Ceccarelli, of the Institute for Planetary Sciences and Astrophysics at the University of Grenoble (IPAG) in France.

The complex organic molecules were found by detecting specific radio frequencies, called spectral lines, emitted by the molecules. Those characteristic radio frequencies serve as "fingerprints" to identify the chemicals.

The astronomers noted that all the chemicals found in hot corinos had been found by detecting these "fingerprints" at radio frequencies corresponding to wavelengths of only a few millimetres.

"We know that dust blocks those wavelengths, so we decided to look for evidence of these chemicals at longer wavelengths that can easily pass through dust," said Claire Chandler of the National Radio Astronomy Observatory, and principal investigator on the project.

"It struck us that dust might be what was preventing us from detecting the molecules in one of the twin protostars," added Chandler.

The astronomers used the VLA to observe a pair of protostars called IRAS 4A, in a star-forming region about 1,000 light-years from Earth. They observed the pair at wavelengths of centimetres.

At those wavelengths, they sought radio emissions from methanol, CH3OH (wood alcohol, not for drinking). This was a pair in which one protostar clearly had a hot corino and the other did not, as seen using the much shorter wavelengths.

The result confirmed their hunch. "With the VLA, both protostars showed strong evidence of methanol surrounding them. This means that both protostars have hot corinos. The reason we did not see the one at shorter wavelengths was because of dust," said Marta de Simone, a graduate student at IPAG who led the data analysis for this object.

The astronomers cautioned that while both hot corinos now are known to contain methanol, there still may be some chemical differences between them. That, they said, can be settled by looking for other molecules at wavelengths not obscured by dust.

"This result tells us that using centimetre radio wavelengths is necessary to properly study hot corinos," Claudio Codella of Arcetri Astrophysical Observatory in Florence, Italy, said.

"In the future, planned new telescopes such as the next-generation VLA and SKA, will be very important to understanding these objects," added Codella.

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Agencies
June 28,2020

The US space agency has thrown open a challenge to win over Rs 26 lakh, calling the global community to send novel design concepts for compact toilets that can operate in both microgravity and lunar gravity.

NASA is preparing for return to the Moon and innumerable activities to equip, shelter, and otherwise support future astronauts are underway.

The astronauts will be eating and drinking, and subsequently urinating and defecating in microgravity and lunar gravity.

NASA said that while astronauts are in the cabin and out of their spacesuits, they will need a toilet that has all the same capabilities as ones here on Earth.

The public designs for space toilet may be adapted for use in the Artemis lunar landers that take humans back to the Moon.

"Although space toilets already exist and are in use (at the International Space Station, for example), they are designed for microgravity only," the US space agency said in a statement.

NASA's Human Landing System Programme is looking for a next-generation device that is smaller, more efficient, and capable of working in both microgravity and lunar gravity.

The new NASA challenge includes a Technical category and Junior category and the last date to send designs is August 17.

NASA's Artemis Moon mission will land the first woman and next man on the lunar surface by 2024.

The Artemis programme is part of America's broader Moon to Mars exploration approach, in which astronauts will explore the Moon and experience gained there to enable humanity's next giant leap, sending humans to Mars.

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News Network
March 18,2020

San Francisco, Mar 18: Facebook said a bug in its anti-spam system temporarily blocked the publication of links to news stories about the coronavirus. Guy Rosen, Facebook's vice president of integrity, said on Twitter Tuesday that the company was working on a fix for the problem.

Users complained that links to news stories about school closings and other information related to the virus outbreak were blocked by the company's automated system.

Later on Tuesday, Rosen tweeted that Facebook had restored all the incorrectly deleted posts, which also covered topics beyond the coronavirus.

Rosen said the problems were unrelated to any changes in Facebook's content-moderator workforce. The company reportedly sent its human moderators home this week because of the coronavirus outbreak.

A representative for Facebook did not immediately respond to questions on the status of Facebook's content moderators, many of whom do not work directly for the company and are not always able to work from home.

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