5 saffron extremists including a Mangalurean are key suspects in Gauri Lankesh murder

Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

We, the undersigned express our solidarity with Dr Zafarul Islam Khan, renowned scholar, journalist and presently Chairman of the Delhi Minorities Commission.

We strongly condemn the continued media trial and targeting of Dr Zafarul Islam Khan for his Facebook post thanking Kuwait for expressing solidarity with Indian Muslims. In his Facebook post, he mentioned the appalling deterioration of human rights of Indian Muslims who have been targeted by Hindutva bigots. A few politicians with ulterior motives and news channel anchors known for spreading bigotry and Islamophobia have mischievously sought to misinterpret his statement and ridiculously label him as anti-Hindu and anti-India.

He has only reiterated what many citizens of India, public figures, international institutions, various European governments, the United States of America and United Nations human rights mechanisms have repeatedly underlined their concern at the increasing human rights abuse and violations of religious minorities in India.

Dr Zafarul Islam Khan is a man of integrity. He is a scholar who is known to stand up for constitutional freedoms and values.

His work as the Chairman of Delhi Minorities Commission has been warmly applauded by human rights activists and NGOs across different faiths. His timely interventions on problems of minorities in Delhi have made him a respectable figure among not only Muslims but Sikh, Christians, Jains and Parsis. He is a humanist in the truest sense of the word.

The hateful propaganda against Dr Khan is one more illustration as how certain Indians fail to differentiate between Hinduism, a religion and Hindutva which is a supremacist political ideology.

Dr Zafarul Islam Khan is a leading Indian intellectual whose niche area is Islamic studies and Arab world. He enjoys great respect in the Arab and Muslim world for his understanding and knowledge. He is an alumni of the esteemed Jamia Al-Azhar and Manchester University.

Dr Khan is known for taking bold public positions. He was the first Muslim scholar in the world who denounced ISIL, which later became IS or ISIS. He issued a statement opposing the barbaric crimes of ISIL (IS or ISIS) and Boko Haram against minorities. He takes strong stands against extremism of all sorts. That makes him a prominent critic of RSS.

Dr Khan is a scholar ambassador and earned international prestige for the India. Any attack and targeting of him, is actually an insult to Indian constitution and ethos.

We demand the appropriate authorities of the Government of India take strong legal action against those who are distorting Dr Khan’s Facebook post, and spreading vicious false propaganda against him.

Signed by:

Swami Agnivesh

Mohammad Adeeb
Arun Kumar (Prof)

Zafar Jung

Kamal Faruqui

Annie Namala

Kavita Krishnan

Subhash Gatade

Jawed Naqvi

Indu Pratap Singh

Avinash Kumar

Iftikhar Gilani

Anil Chamadia

Xavier Dias

Denzil Fernandes (Dr)

Irfan Engineer

Faisal Khan

John Dayal (Dr)

Mujtaba Farooque

Ravi Nair

Abubakr Sabbaq (Adv)

Gopal Menon

Bilal Khan

Ashok Choudhury

Jaffer Latief Najar

Mujahid Nafis

Aseem Sundan

Poojan Sahil

Ankur Otto

Mariya Salim

Tanweer Alam

Juned Khan

E M Abdul Rahiman

Aditi Dutta

Devika Prasad

Ameeque Jamei

Suhaib Ansari

Gurminder Singh

A C Michael

Neelima Sharma

Aftab Alam (Dr)

Dhruva Narayan

Syed Saif Ur Rahman

Tanweer Fazal (Dr)

Thouseef Madikeri (Dr)

N.D. Jayaprakash

Salahuddin Ansari

Satyajeet Nambiar

Suhail KK

Abu Sufiyan

Sujata Madhok

Tariq Khan

Violin Mathew Benjamin

Shamsul Islam (Prof)

Sreedhar Ramamurthi

Mohd. Shahid (Prof)

Anand Vivek Taneja (Dr)

Kush Kumar Singh (Dr)

Mangla Verma

Vipul Kumar

Waquar Hasan

Braham Prakash

Abdul Rashid Agwan

Fawaz Shaheen

Guman Singh

Mohammed Hafeez Ulla

Kp Sasi

Mushfique Raza Khan

Partha S Banerjee

Gautam Majumdar

S.Q. Masood

Aiman J Khan

M. K. Faizy

Tasleem Rehmani (Dr)

Mohammed Shafi

Lenin Raghuvanshi (Dr)

Malik Motasim Khan

Kripal Singh Mandloi

Labeed Shafi

Qamar Intakhab

Raees Ahmed Siddiqui

Laeeq Ahmed Khan

Anthony Arulraj

Sadiq Zafar

Biju Gopidasan

George Pulikuthiyil

Mohd Abdullah

Mohd Sorab Hussain

Mukunda Kattel

Sandeep Pendse

Paul Newman

Ovais Sultan Khan

Bengaluru, Apr 16: With two more people testing positive for COVID-19 in Karnataka, the state's corona cases count has reached 279, including 80 discharged and 12 deaths, said the government on Wednesday.

A total of 19 corona cases were confirmed in the state on Wednesday. 17 cases were reported earlier in the day, of which 15 are male patients and two are female. Of the 17 cases, nine are workers of a pharmaceutical company in Mysuru, the government stated.

Meanwhile, a 65-year-old from Chikkaballapur, who had tested positive for COVID-19, lost his life this afternoon.

"He was referred to a Bengaluru hospital with complaints of H1N1 positive, chronic obstructive pulmonary disease with obstructive sleep apnea and a past history of diabetes and hypertension," the government said.