Deve Gowda openly abuses Karnataka CM, calls him ‘neecha’, claims credit for his growth

Bengaluru, May 24: Karnataka Tourism Minister CT Ravi said that coronavirus lockdown has severely marred the tourism industry in the state and the government will revive it in a phased manner.

"It would be beneficial if hotels are opened keeping in mind few restrictions. At present, the tourism industry has fallen flat making it very difficult to promote tourism in the state," Ravi said.

"Our department has planned to promote tourism in a phased manner. In the first phase, we would focus on native tourism; then in the second phase, we will promote inter-district travel; in the third phase, we will put weight behind inter-state tourism and in the fourth phase, we would be promoting international travel and tourism," he added.

Karnataka's COVID-19 count surges to 1,958 with 216 new cases of the virus reported in the last 24 hours, said the Health Department in a bulletin on Saturday.

Out of the total number of cases, 1,307 patients are active cases and 608 patients have been discharged. The total number of fatalities due to COVID-19 in the state has risen to 42.

Thiruvanathapuram, Mar 27: The state is heading for its worst ever crisis with coronavirus cases increasing rapidly and Kasargod district the worst hit. On Friday alone 39 positive cases were reported in the state of which 34 are from Kasargod.

Chief minister Pinarayi Vijayan said the situation is grave and Kasargod has been the worst hit. More than the positive cases reported in the district, the worrying factor is that many people have come into contact with these positive cases.

The chief minister warned that the government will be forced to declare the names of the people who are defying the quarantine guidelines in the district. More people have been put under risk in the district and the district administration is much concerned since the results of 215 samples are yet to come.

There is no other way but to tighten the restrictions imposed in the district against the people coming out of their houses. The government has decided to provide more facilities to the hospitals in Kasargod and Kannur to meet an emergency.

The medical college hospital in Kannur will be converted into a coronavirus hospital with 200 bed strength. Steps have been taken to equip the medical college hospital with more facilities. The Central University at kasargood will be converted into as a temporary coronavirus treatment centre. 

The state has also requested permission from ICMR to begin the testing facility here, said the chief minister.

The total number of positive cases reported in the state have now become 176 of which 12 have been discharged after testing negative. At present 164 positive people are admitted in several hospitals of the state.

On Friday of the 39 positive cases, two are from Kannur and one each from Thrissur, Kollam and Kozhikode. With this all the districts in the state have been now affected with coronavirus.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.