Don't be so clean! Obsession with hygiene could kill benefial bacterias

February 20, 2017

New Delhi, Feb 20: Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

water

Providing clean water to everyone on the planet has been a major health goal for decades, but scientists have warned that while it reduces the chance of catching a deadly disease it could also increase the risk of asthma.

Speaking at the annual meeting of the American Association for the Advancement of Science in Boston, Dr Brett Finlay suggested the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

In a study in Canada, the researchers had found the presence of four types of bacteria in the gut of babies less than 100 days old seemed to prevent them from developing asthma in later life.

They then decided to see if the same was true for children elsewhere in the world and settled on Ecuador, where about 10 per cent of children have asthma, for their next study.

They found the same protective effect of the four bugs, but also two unexpected factors that increased the risk of the condition: a particular type of yeast in the gut and access to a clean water supply.

Dr Finley, of British Columbia University, said: "Ironically the kids with clean water had a higher risk of asthma.

"I guess it makes sense [because of the lower levels of bacteria] but I must admit we were surprised to see that. You'd think clean water is good for the world."

The hygiene hypothesis has emerged as one reason to explain the rise of asthma and allergies in the developed world.

But despite this Dr Finlay, author of the book Let Them Eat Dirt, said too many people still felt the need to kill bugs and urged them to throw away their anti-bacterial wipes.

"I would say we're suffering from a hygiene hangover. We have cleaned the world up too much," he said.

"Maybe these microbes are actually an endangered species - your great grandkids are going to have different microbes than you do.

"There are people biobanking things - I'm not suggesting you should biobank your poop now and give it to your grandkids .. I don't know . I worry we have got too clean and we have got to ease off a little bit.

"We have evolved with these microbe all along.

"I do think we have to rethink this absolute war on all microbes - 'kill them all, carpet bomb them' - I think that's wrong."

However, he stressed there were benefits to being clean.

"Hygiene works - we have got rid of infectious diseases, no doubt about it, but this is a consequence of that," he said.

"Certain microbes fix one condition but make another worse . so it's complex."

While the role of gut microbes in human health is now widely accepted, Dr Finlay said when they first suggested a link between their make-up and asthma "people thought we were from Mars".

"These microbes in the gut are setting the immune system up and different parts of the body talk to each other," he said.

But now research was increasingly pointing to the role of fungi like yeast in the gut and even "the

other elephant in the room", viruses.

"This is just a wake-up call - we have to think about more than bacteria," he said.

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Agencies
June 10,2020

Early treatment with the antiviral drug remdesivir has been found to reduce viral load and prevent lung disease in macaques infected with SARS-CoV-2 that causes COVID-19, according to a study.

The findings, published in the journal Nature on Tuesday, support the early use of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia.

Researchers from the National Institutes of Health in the US noted that remdesivir has broad antiviral activity and has been shown to be effective against infections with SARS-CoV and MERS-CoV in animal models.

The drug is being tested in human clinical trials for the treatment of COVID-19, they said.

Researcher Emmie de Wit and colleagues investigated the effects of remdesivir treatment in rhesus macaques, a recently established model of SARS-CoV-2 infection.

Two sets of six macaques were inoculated with SARS-CoV-2.

One group was treated with remdesivir 12 hours later -- close to the peak of virus reproduction in the lungs -- and these macaques received treatment every 24 hours until six days after inoculation.

In contrast to the control group, the researchers found that macaques that received remdesivir did not show signs of respiratory disease, and had reduced damage to the lungs.

Viral loads in the lower respiratory tract were also reduced in the treated animals; viral levels were around 100 times lower in the lower-respiratory tract of remdesivir-treated macaques 12 hours after the first dose, they said.

The researchers said that infectious virus could no longer be detected in the treatment group three days after initial infection, but was still detectable in four out of six control animals.

Despite this virus reduction in the lower respiratory tract, no reduction in virus shedding was observed, which indicates that clinical improvement may not equate to a lack of infectiousness, they said.

Dosing of remdesivir in the rhesus macaques is equivalent to that used in humans, the researchers noted.

They cautioned that it is difficult to directly translate the timing of treatment used in corresponding disease stages in humans, because rhesus macaques normally develop only mild disease.

However, researchers said the results indicate that remdesivir treatment of COVID-19 should be initiated as early as possible to achieve the maximum treatment effect.

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Agencies
March 27,2020

New Delhi, Mar 27: The Centre has restricted sale and distribution of "hydroxychloroquine" declaring it as an essential drug to treat the COVID-19 patients and meet the requirements of emergency arising due to the pandemic.

The Ministry of Health and Family Welfare on Thursday made the announcement making it clear that the order "shall come into force on the date of its publication in the official Gazette".

In the order, the government declared that the Central government is "satisfied that the drug hydroxychloroquine is essential to meet the requirements of emergency arising due to pandemic COVID-19 and in the public interest, it is necessary and expedient to regulate and restrict the sale and distribution of the drug 'hydroxychloroquine' and preparation based thereon for preventing their misuse".

"Now, therefore, in exercise of the powers conferred by Section 26B of the Drugs and Cosmetics Act, 1940 (23 of 1940), the Central government hereby directs that sale by retail of any preparation containing the drug Hydroxychloroquine shall be in accordance with the conditions for sale of drugs specified in Schedule H1 to the Drugs and Cosmetics Rules, 1945."

The order came at a time when the novel coronavirus claimed 16 lives and infected over 600 people across India.

The announcement regarding ban of sale and distribution of the drug was made by the government earlier but it issued an official Gazette notification on Thursday signalling that hydroxychloroquine -- an anti-Malaria drug -- will work as a medicine for treating coronavirus infected patients as well.

Recently, the national task force for COVID-19 constituted by Indian Council for Medical Research (ICMR) has recommended hydroxy-chloroquine as a preventive medication.

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Agencies
January 16,2020

Thiruvananthapuram, Jan 16: Kerala Tourism on Wednesday shared a recipe of a popular meat dish in the Central Travancore region of Kerala, Beef Ularthiyathu, which is a special delicacy in the region.

Taking to its Twitter handle, the Kerala Tourism wrote, "Tender chunks of beef, slow-roasted with aromatic spices, coconut pieces, and curry leaves. A recipe for the most classic dish, Beef Ularthiyathu, the stuff of legends, from the land of spices, Kerala."

The State Tourism also shared the recipe of the delicacy with Twitteratis.

The tweet which has garnered 3.5 thousand likes so far had received a mixed response

While some said "beef is not Kerala's culture", others termed the recipe 'a match made in heaven".

Dr Vireandta Jilowa wrote, "Surprised to see it, that beef is being consumed despite BJP government in the Centre."

"We are not slaves of BJP at the Centre....people eat whatever they like in this state, including beef, pork, mutton and fish," another user Tatheesh Vijayakumar wrote.

In 2017, The Minister for Environment, Forest and Climate Change Harsh Vardhan had ordered that the ministry has notified the Prevention of Cruelty to Animals (Regulation of Livestock Markets) Rules, 2017 to ensure that the sale of cattle is not meant for slaughter purposes.

Regulating animal trade is a state business, but animal welfare is a central subject.

In lieu of this, there was widespread opposition of the order, with many states openly denying accepting the notification.

Porotta and Kappa biriyani with beef are counted as delicacies by Keralites. 

Also Read: The Art of Prepping Meat

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